Reference on EC 3.1.3.48 - protein-tyrosine-phosphatase and Organism(s) Homo sapiens and UniProt Accession Q92932
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Boivin, P.; Galand, C.
The human red cell acid phosphatase is a phosphotyrosine protein phosphatase which dephosphorylates the membrane protein band 3
Biochem. Biophys. Res. Commun.
134
557-564
1986
Homo sapiens
Roome, J.; O'Hare, T.; Pilch, P.F.; Brautigan, D.L.
Protein phosphotyrosine phosphatase purified from the particulate fraction of human placenta dephosphorylates insulin and growth-factor receptors
Biochem. J.
256
493-500
1988
Homo sapiens
Tonks, N.K.; Diltz, C.D.; Fischer, E.H.
Characterization of the major protein-tyrosine-phosphatases of human placenta
J. Biol. Chem.
263
6731-6737
1988
Homo sapiens
Tonks, N.K.; Diltz, C.D.; Fischer, E.H.
Purification of the major protein-tyrosine-phosphatases of human placenta
J. Biol. Chem.
263
6722-6730
1988
Homo sapiens
Waheed, A.; Laidler, P.M.; Wo, Y.Y.P.; Van Etten, R.L.
Purification and physicochemical characterization of a human placental acid phosphatase possessing phosphotyrosyl protein phosphatase activity
Biochemistry
27
4265-4273
1988
Homo sapiens
Clari, G.; Brunati, A.M.; Moret, V.
Partial purification and characterization of phosphotyrosyl-protein phosphatase(s) from human erythrocyte cytosol
Biochem. Biophys. Res. Commun.
137
566-572
1986
Homo sapiens
Zhao, Z.; Laroque, R.; Ho, W.T.; Fischer, E.H.; Shen, S.H.
Purification and characterization of PTP2C, a widely distributed protein tyrosine phosphatase containing two SH2 domains
J. Biol. Chem.
269
8780-8785
1994
Homo sapiens
Brautigan, D.L.; Bornstein, P.; Gallis, B.
Phosphotyrosyl-protein phosphatase. Specific inhibition by Zn
J. Biol. Chem.
256
6519-6522
1981
Homo sapiens
Foulkes, J.G.
Phosphotyrosyl-protein phosphatases
Curr. Top. Microbiol. Immunol.
107
163-180
1983
Gallus gallus, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus
Lau, K.H.W.; Farley, J.R.; Baylink, D.J.
Phosphotyrosyl protein phosphatases
Biochem. J.
257
23-36
1989
Gallus gallus, Homo sapiens, Mus musculus
Modesti, A.; Marzocchini, R.; Raugei, G.; Chiti, F.; Sereni, A.; Magherini, F.; Ramponi, G.
Cloning, expression and characterization of new human low Mr phosphotyrosine protein phosphatase originating by alternative splicing
FEBS Lett.
431
111-115
1998
Homo sapiens
Hundt, M.; Schmidt, R.E.
Functional characterization of receptor-type protein tyrosine phosphatase CD148 (HPTPeta/DEP-1) in Fcgamma receptor IIa signal transduction of human neutrophils
Eur. J. Immunol.
27
3532-3535
1997
Homo sapiens
Gu, M.; Majerus, P.W.
The properties of the protein tyrosine phosphatase PTPMEG
J. Biol. Chem.
271
27751-27759
1996
Homo sapiens
Cui, L.; Yu, W.P.; DeAizpurua, H.J.; Schmidli, R.S.; Pallen, C.J.
Cloning and characterization of islet cell antigen-related protein-tyrosine phosphatase (PTP), a novel receptor-like PTP and autoantigen in insulin-dependent diabetis
J. Biol. Chem.
271
24817-24823
1996
Homo sapiens
Sorio, C.; Mendrola, J.; Lou, Z.; LaForgia, S.; Croce, C.M.; Huebner, K.
Characterization of the receptor protein tyrosine phosphatase gene product PTPgamma: binding and activation by triphosphorylated nucleotides
Cancer Res.
55
4855-4864
1995
Homo sapiens
Dechert, U.; Adam, M.; Harder, K.W.; Clark-Lewis, I.; Jirik, F.
Characterization of protein tyrosine phosphatase SH-PTP2. Study of phosphopeptide substrates and possible regulatory role of SH2 domains
J. Biol. Chem.
269
5602-5611
1984
Homo sapiens (Q06124)
Hoppe, E.; Berne, P.F.; Stock, D.; Rasmussen, J.S.; Moller, N.P.H.
Expression, purification and crystallization of human phosphotyrosine phosphatase 1B
Eur. J. Biochem.
223
1069-1077
1994
Homo sapiens
Harder, K.W.; Owen, P.; Wong, L.K.H.; Aebersold, R.; Clark-Lewis, I.; Jirik, F.R.
Characterization and kinetic analysis of the intracellular domain of human protein tyrosine phosphatase beta (HPTPbeta) using synthetic phosphopeptides
Biochem. J.
298
395-401
1994
Homo sapiens
-
Sugimoto, S.; Lechleider, R.J.; Shoelson, S.E.; Neel, B.G.; Walsh, C.T.
Expression, purification, and characterization of SH2-containing protein tyrosine phosphatase, SH-PTP2
J. Biol. Chem.
268
227711-22776
1993
Homo sapiens
-
Pei, D.; Neel, B.G.; Walsh, C.T.
Overexpression, purification, and characterization of SHPTPa, a src homology 2-containing protein-tyrosine-phosphatase
Proc. Natl. Acad. Sci. USA
90
1092-1096
1993
Homo sapiens
Cohen, S.; Dadi, H.; Shaoul, E.; Sharfe, N.; Riofam, C.M.
Cloning and characterization of a lymphoid-specific inducible human protein tyrosine phosphatase, Lyp
Blood
93
2013-2024
1999
Homo sapiens (Q9Y2R2), Homo sapiens
Daum, G.; Zander, N.F.; Morse, B.; Hurwitz, D.; Schlessinger, J.; Fischer, E.H.
Characterization of a human recombinant receptor-like protein tyrosine phosphatase
J. Biol. Chem.
266
12211-12215
1991
Homo sapiens
Tonks, N.K.; Diltz, C.D.; Fischer, E.H.
CD45, an integral membrane protein tyrosine phosphatase. Characterization of enzyme activity
J. Biol. Chem.
256
10674-10680
1990
Homo sapiens
Barford, D.; Flint, A.J.; Tonks, N.K.
Crystal structure of human protein tyrosine phosphatase 1B
Science
263
1397-1404
1994
Homo sapiens
Thompson, L.J.; Jiang, J.; Madamanchi, N.; Runge, M.S.; Patterson, C.
PTP-epsilon, a tyrosine phosphatase expressed in endothelium, negatively regulates endothelial cell proliferation
Am. J. Physiol.
281
H396-H403
2001
Homo sapiens
Romsicki, Y.; Kennedy, B.P.; Asante-Appiah, E.
Purification and characterization of T cell protein tyrosine phosphatase reveals significant functional homology to protein tyrosine phosphatase-1B
Arch. Biochem. Biophys.
414
40-50
2003
Homo sapiens
Pedersen, A.K.; Guo, X.L.; Moller, K.B.; Peters, G.H.; Andersen, H.S.; Kastrup, J.S.; Mortensen, S.B.; Iversen, L.F.; Zhang, Z.Y.; Moller, N.P.H.
Residue 182 influences the second step of protein-tyrosine phosphatase-mediated catalysis
Biochem. J.
378
421-433
2004
Homo sapiens (P18031)
Xie, L.; Zhang, Y.L.; Zhang, Z.Y.
Design and characterization of an improved protein tyrosine phosphatase substrate-trapping mutant
Biochemistry
41
4032-4039
2002
Homo sapiens
Raugei, G.; Ramponi, G.; Chiarugi, P.
Low molecular weight protein tyrosine phosphatases: small, but smart
Cell. Mol. Life Sci.
59
941-949
2002
Homo sapiens, Mammalia
Zhang, Z.Y.
Protein tyrosine phosphatases: prospects for therapeutics
Curr. Opin. Chem. Biol.
5
416-423
2001
Homo sapiens
Kolmodin, K.; Aqvist, J.
The catalytic mechanism of protein tyrosine phosphatases revisited
FEBS Lett.
498
208-213
2001
Saccharomyces cerevisiae, Homo sapiens, Yersinia enterocolitica
Peters, G.H.; Iversen, L.F.; Branner, S.; Andersen, H.S.; Mortensen, S.B.; Olsen, O.H.; Moller, K.B.; Moller, N.P.H.
Residue 259 is a key determinant of substrate specificity of protein-tyrosine phosphatases 1B and alpha
J. Biol. Chem.
275
18201-18209
2000
Homo sapiens
Vetter, S.W.; Keng, Y.F.; Lawrence, D.S.; Zhang, Z.Y.
Assessment of protein-tyrosine phosphatase 1B substrate specificity using "inverse alanine scanning"
J. Biol. Chem.
275
2265-2268
2000
Homo sapiens
Yang, J.; Cheng, Z.; Niu, T.; Liang, X.; Zhao, Z.J.; Zhou, G.W.
Structural basis for substrate specificity of protein-tyrosine phosphatase SHP-1
J. Biol. Chem.
275
4066-4071
2000
Homo sapiens (P29350)
Romsicki, Y.; Scapin, G.; Beaulieu-Audy, V.; Patel, S.; Becker, J.W.; Kennedy, B.P.; Asante-Appiah, E.
Functional characterization and crystal structure of the C215D mutant of protein-tyrosine phosphatase-1B
J. Biol. Chem.
278
29009-29015
2003
Homo sapiens (P18031)
Yang, J.; Liu, L.; He, D.; Song, X.; Liang, X.; Zhao, Z.J.; Zhou, G.W.
Crystal structure of human protein-tyrosine phosphatase SHP-1
J. Biol. Chem.
278
6516-6520
2003
Homo sapiens
Qi, Y.; Zhao, R.; Cao, H.; Sui, X.; Krantz, S.B.; Zhao, Z.J.
Purification and characterization of protein tyrosine phosphatase PTP-MEG2
J. Cell. Biochem.
86
79-89
2002
Homo sapiens
Wabakken, T.; Hauge, H.; Funderud, S.; Aasheim, H.C.
Characterization, expression and functional aspects of a novel protein tyrosine phosphatase epsilon isoform
Scand. J. Immunol.
56
276-285
2002
Homo sapiens (Q8TE48), Homo sapiens
Welte, S.; Baringhaus, K.H.; Schmider, W.; Mueller, G.; Petry, S.; Tennagels, N.
6,8-Difluoro-4-methylumbiliferyl phosphate: a fluorogenic substrate for protein tyrosine phosphatases
Anal. Biochem.
338
32-38
2005
Homo sapiens, Yersinia sp.
Park, J.; Pei, D.
Trans-b-nitrostyrene derivatives as slow-binding inhibitors of protein tyrosine phosphatases
Biochemistry
43
15014-15021
2004
Homo sapiens
Peters, G.H.; Iversen, L.F.; Andersen, H.S.; Moller, N.P.; Olsen, O.H.
Residue 259 in protein-tyrosine phosphatase PTP1B and PTPalpha determines the flexibility of glutamine 262
Biochemistry
43
8418-8428
2004
Homo sapiens (P18031)
Lee, H.; Xie, L.; Luo, Y.; Lee, S.Y.; Lawrence, D.S.; Wang, X.B.; Sotgia, F.; Lisanti, M.P.; Zhang, Z.Y.
Identification of phosphocaveolin-1 as a novel protein tyrosine phosphatase 1B substrate
Biochemistry
45
234-240
2006
Homo sapiens
Shim, Y.S.; Kim, K.C.; Lee, K.A.; Shrestha, S.; Lee, K.H.; Kim, C.K.; Cho, H.
Formylchromone derivatives as irreversible and selective inhibitors of human protein tyrosine phosphatase 1B. Kinetic and modeling studies
Bioorg. Med. Chem.
13
1325-1332
2005
Homo sapiens (P18031), Homo sapiens
Moretto, A.F.; Kirincich, S.J.; Xu, W.X.; Smith, M.J.; Wan, Z.K.; Wilson, D.P.; Follows, B.C.; Binnun, E.; Joseph-McCarthy, D.; Foreman, K.; Erbe, D.V.; Zhang, Y.L.; Tam, S.K.; Tam, S.Y.; Lee, J.
Bicyclic and tricyclic thiophenes as protein tyrosine phosphatase 1B inhibitors
Bioorg. Med. Chem.
14
2162-2177
2006
Homo sapiens
Puius, Y.A.; Zhao, Y.; Sullivan, M.; Lawrence, D.S.; Almo, S.C.; Zhang, Z.Y.
Identification of a second aryl phosphate-binding site in protein-tyrosine phosphatase 1B: a paradigm for inhibitor design
Proc. Natl. Acad. Sci. USA
94
13420-13425
1997
Homo sapiens (P18031), Homo sapiens
Na, M.; Oh, W.K.; Kim, Y.H.; Cai, X.F.; Kim, S.; Kim, B.Y.; Ahn, J.S.
Inhibition of protein tyrosine phosphatase 1B by diterpenoids isolated from Acanthopanax koreanum
Bioorg. Med. Chem. Lett.
16
3061-3064
2006
Homo sapiens
McCain, D.F.; Wu, L.; Nickel, P.; Kassack, M.U.; Kreimeyer, A.; Gagliardi, A.; Collins, D.C.; Zhang, Z.Y.
Suramin derivatives as inhibitors and activators of protein-tyrosine phosphatases
J. Biol. Chem.
279
14713-14725
2004
Homo sapiens, Yersinia sp.
Lund, I.K.; Andersen, H.S.; Iversen, L.F.; Olsen, O.H.; Moller, K.B.; Pedersen, A.K.; Ge, Y.; Holsworth, D.D.; Newman, M.J.; Axe, F.U.; Moller, N.P.
Structure-based design of selective and potent inhibitors of protein-tyrosine phosphatase beta
J. Biol. Chem.
279
24226-24235
2004
Homo sapiens (P18031), Homo sapiens
Zabolotny, J.M.; Haj, F.G.; Kim, Y.B.; Kim, H.J.; Shulman, G.I.; Kim, J.K.; Neel, B.G.; Kahn, B.B.
Transgenic overexpression of protein-tyrosine phosphatase 1B in muscle causes insulin resistance, but overexpression with leukocyte antigen-related phosphatase does not additively impair insulin action
J. Biol. Chem.
279
24844-24851
2004
Homo sapiens
Lin, S.Y.; Raval, S.; Zhang, Z.; Deverill, M.; Siminovitch, K.A.; Branch, D.R.; Haimovich, B.
The protein-tyrosine phosphatase SHP-1 regulates the phosphorylation of alpha-actinin
J. Biol. Chem.
279
25755-25764
2004
Homo sapiens
Liang, F.; Lee, S.Y.; Liang, J.; Lawrence, D.S.; Zhang, Z.Y.
The role of protein-tyrosine phosphatase 1B in integrin signaling
J. Biol. Chem.
280
24857-24863
2005
Homo sapiens
Xu, Y.; Tan, L.J.; Grachtchouk, V.; Voorhees, J.J.; Fisher, G.J.
Receptor-type protein-tyrosine phosphatase-kappa regulates epidermal growth factor receptor function
J. Biol. Chem.
280
42694-42700
2005
Homo sapiens
Wu, J.; Katrekar, A.; Honigberg, L.A.; Smith, A.M.; Conn, M.T.; Tang, J.; Jeffery, D.; Mortara, K.; Sampang, J.; Williams, S.R.; Buggy, J.; Clark, J.M.
Identification of substrates of human protein-tyrosine phosphatase PTPN22
J. Biol. Chem.
281
11002-11010
2006
Homo sapiens
Montalibet, J.; Skorey, K.; McKay, D.; Scapin, G.; Asante-Appiah, E.; Kennedy, B.P.
Residues distant from the active site influence protein-tyrosine phosphatase 1B inhibitor binding
J. Biol. Chem.
281
5258-5266
2006
Homo sapiens (P18031)
Asante-Appiah, E.; Patel, S.; Desponts, C.; Taylor, J.M.; Lau, C.; Dufresne, C.; Therien, M.; Friesen, R.; Becker, J.W.; Leblanc, Y.; Kennedy, B.P.; Scapin, G.
Conformation-assisted inhibition of protein-tyrosine phosphatase-1B elicits inhibitor selectivity over T-cell protein-tyrosine phosphatase
J. Biol. Chem.
281
8010-8015
2006
Homo sapiens
Nam, H.J.; Poy, F.; Saito, H.; Frederick, C.A.
Structural basis for the function and regulation of the receptor protein tyrosine phosphatase CD45
J. Exp. Med.
201
441-452
2005
Homo sapiens
Rouleau, C.; Roy, A.; St Martin, T.; Dufault, M.R.; Boutin, P.; Liu, D.; Zhang, M.; Puorro-Radzwill, K.; Rulli, L.; Reczek, D.; Bagley, R.; Byrne, A.; Weber, W.; Roberts, B.; Klinger, K.; Brondyk, W.; Nacht, M.; Madden, S.; Burrier, R.; Shankara, S.; Teicher, B.A.
Protein tyrosine phosphatase PRL-3 in malignant cells and endothelial cells: expression and function
Mol. Cancer Ther.
5
219-229
2006
Homo sapiens
Wiesmann, C.; Barr, K.J.; Kung, J.; Zhu, J.; Erlanson, D.A.; Shen, W.; Fahr, B.J.; Zhong, M.; Taylor, L.; Randal, M.; McDowell, R.S.; Hansen, S.K.
Allosteric inhibition of protein tyrosine phosphatase 1B
Nat. Struct. Mol. Biol.
11
730-737
2004
Homo sapiens (P18031), Homo sapiens
Na, M.; Oh, W.K.; Kim, Y.H.; Cai, X.F.; Kim, S.; Kim, B.Y.; Ahn, J.S.
Na, M.; Yang, S.; He, L.; Oh, H.; Kim, B.S.; Oh, W.K.; Kim, B.Y.; Ahn, J.S.: Inhibition of protein tyrosine phosphatase 1B by ursane-type triterpenes isolated from Symplocos paniculata
Planta Med.
72
261-263
2006
Homo sapiens
Eswaran, J.; Debreczeni, J.E.; Longman, E.; Barr, A.J.; Knapp, S.
The crystal structure of human receptor protein tyrosine phosphatase kappa phosphatase domain 1
Protein Sci.
15
1500-1505
2006
Homo sapiens
Evdokimov, A.G.; Pokross, M.; Walter, R.; Mekel, M.; Cox, B.; Li, C.; Bechard, R.; Genbauffe, F.; Andrews, R.; Diven, C.; Howard, B.; Rastogi, V.; Gray, J.; Maier, M.; Peters, K.G.
Engineering the catalytic domain of human protein tyrosine phosphatase beta for structure-based drug discovery
Acta Crystallogr. Sect. D
62
1435-1445
2006
Homo sapiens (P23467), Homo sapiens
Jeong, D.G.; Cho, Y.H.; Yoon, T.S.; Kim, J.H.; Son, J.H.; Ryu, S.E.; Kim, S.J.
Structure of human DSP18, a member of the dual-specificity protein tyrosine phosphatase family
Acta Crystallogr. Sect. D
62
582-588
2006
Homo sapiens
Eswaran, J.; von Kries, J.P.; Marsden, B.; Longman, E.; Debreczeni, J.E.; Ugochukwu, E.; Turnbull, A.; Lee, W.H.; Knapp, S.; Barr, A.J.
Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases
Biochem. J.
395
483-491
2006
Homo sapiens
Rudolph, J.
Cdc25 phosphatases: structure, specificity, and mechanism
Biochemistry
46
3595-3604
2007
Homo sapiens
Sohn, J.; Buhrman, G.; Rudolph, J.
Kinetic and structural studies of specific protein-protein interactions in substrate catalysis by Cdc25B phosphatase
Biochemistry
46
807-818
2007
Homo sapiens (P30305)
Forte, E.; Orsatti, L.; Talamo, F.; Barbato, G.; De Francesco, R.; Tomei, L.
Ezrin is a specific and direct target of protein tyrosine phosphatase PRL-3
Biochim. Biophys. Acta
1783
334-344
2008
Homo sapiens
Ferreira, C.V.; Justo, G.Z.; Souza, A.C.; Queiroz, K.C.; Zambuzzi, W.F.; Aoyama, H.; Peppelenbosch, M.P.
Natural compounds as a source of protein tyrosine phosphatase inhibitors: application to the rational design of small-molecule derivatives
Biochimie
88
1859-1873
2006
Homo sapiens, Homo sapiens (P30304), Homo sapiens (P30305), Homo sapiens (P30307)
Sohn, J.; Rudolph, J.
Temperature dependence of binding and catalysis for the Cdc25B phosphatase
Biophys. Chem.
125
549-555
2007
Homo sapiens
Kochinyan, S.; Sun, L.; Ghosh, I.; Barshevsky, T.; Xu, J.; Xu, M.Q.
Use of intein-mediated phosphoprotein arrays to study substrate specificity of protein phosphatases
Biotechniques
42
63-69
2007
Homo sapiens
Iervolino, A.; Iuliano, R.; Trapasso, F.; Viglietto, G.; Melillo, R.M.; Carlomagno, F.; Santoro, M.; Fusco, A.
The receptor-type protein tyrosine phosphatase J antagonizes the biochemical and biological effects of RET-derived oncoproteins
Cancer Res.
66
6280-6287
2006
Homo sapiens
Seiner, D.R.; LaButti, J.N.; Gates, K.S.
Kinetics and mechanism of protein tyrosine phosphatase 1B inactivation by acrolein
Chem. Res. Toxicol.
20
1315-1320
2007
Homo sapiens
Lavecchia, A.; Cosconati, S.; Limongelli, V.; Novellino, E.
Modeling of Cdc25B dual specificity protein phosphatase inhibitors: docking of ligands and enzymatic inhibition mechanism
ChemMedChem
1
540-550
2006
Homo sapiens (P30305), Homo sapiens
Nascimento, M.; Zhang, W.W.; Ghosh, A.; Houston, D.R.; Berghuis, A.M.; Olivier, M.; Matlashewski, G.
Identification and characterization of a protein-tyrosine phosphatase in Leishmania: Involvement in virulence
J. Biol. Chem.
281
36257-36268
2006
Homo sapiens, Leishmania infantum, Leishmania major, Leishmania donovani (Q0PEE2), Leishmania major Friedlin V9, Leishmania donovani 1S/Cl2D (Q0PEE2)
Varmeh-Ziaie, S.; Manfredi, J.J.
The dual specificity phosphatase Cdc25B, but not the closely related Cdc25C, is capable of inhibiting cellular proliferation in a manner dependent upon its catalytic activity
J. Biol. Chem.
282
24633-24641
2007
Homo sapiens (P30305), Homo sapiens (P30307), Homo sapiens
Picha, K.M.; Patel, S.S.; Mandiyan, S.; Koehn, J.; Wennogle, L.P.
The role of the C-terminal domain of protein tyrosine phosphatase-1B in phosphatase activity and substrate binding
J. Biol. Chem.
282
2911-2917
2007
Homo sapiens
Jeong, D.G.; Yoon, T.S.; Kim, J.H.; Shim, M.Y.; Jung, S.K.; Son, J.H.; Ryu, S.E.; Kim, S.J.
Crystal structure of the catalytic domain of human MAP kinase phosphatase 5: structural insight into constitutively active phosphatase
J. Mol. Biol.
360
946-955
2006
Homo sapiens (Q16828), Homo sapiens (Q99956), Homo sapiens (Q9Y6W6), Homo sapiens
Chen, Y.; Xu, Y.; Bao, Q.; Xing, Y.; Li, Z.; Lin, Z.; Stock, J.B.; Jeffrey, P.D.; Shi, Y.
Structural and biochemical insights into the regulation of protein phosphatase 2A by small t antigen of SV40
Nat. Struct. Mol. Biol.
14
527-534
2007
Homo sapiens
Owens, D.M.; Keyse, S.M.
Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases
Oncogene
26
3203-3213
2007
Homo sapiens
Yu, X.; Sun, J.P.; He, Y.; Guo, X.; Liu, S.; Zhou, B.; Hudmon, A.; Zhang, Z.Y.
Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases
Proc. Natl. Acad. Sci. USA
104
19767-19772
2007
Homo sapiens
Zhang, X.; Guo, A.; Yu, J.; Possemato, A.; Chen, Y.; Zheng, W.; Polakiewicz, R.D.; Kinzler, K.W.; Vogelstein, B.; Velculescu, V.E.; Wang, Z.J.
Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T
Proc. Natl. Acad. Sci. USA
104
4060-4064
2007
Homo sapiens
Kim, S.J.; Jeong, D.G.; Yoon, T.S.; Son, J.H.; Cho, S.K.; Ryu, S.E.; Kim, J.H.
Crystal structure of human TMDP, a testis-specific dual specificity protein phosphatase: implications for substrate specificity
Proteins
66
239-245
2007
Homo sapiens
Barr, A.J.; Knapp, S.
MAPK-specific tyrosine phosphatases: new targets for drug discovery?
Trends Pharmacol. Sci.
27
525-530
2006
Homo sapiens (P35236), Homo sapiens (P54829), Homo sapiens (Q15256), Homo sapiens
Korporaal, S.J.; Koekman, C.A.; Verhoef, S.; van der Wal, D.E.; Bezemer, M.; Van Eck, M.; Akkerman, J.W.
Downregulation of platelet responsiveness upon contact with LDL by the protein-tyrosine phosphatases SHP-1 and SHP-2
Arterioscler. Thromb. Vasc. Biol.
29
372-379
2009
Homo sapiens
Critton, D.A.; Tortajada, A.; Stetson, G.; Peti, W.; Page, R.
Structural basis of substrate recognition by hematopoietic tyrosine phosphatase
Biochemistry
47
13336-13345
2008
Homo sapiens (P35236)
Zhang, X.Y.; Chen, V.L.; Rosen, M.S.; Blair, E.R.; Lone, A.M.; Bishop, A.C.
Allele-specific inhibition of divergent protein tyrosine phosphatases with a single small molecule
Bioorg. Med. Chem.
16
8090-8097
2008
Homo sapiens (P18031)
Zhang, Y.N.; Zhang, W.; Hong, D.; Shi, L.; Shen, Q.; Li, J.Y.; Li, J.; Hu, L.H.
Oleanolic acid and its derivatives: new inhibitor of protein tyrosine phosphatase 1B with cellular activities
Bioorg. Med. Chem.
16
8697-8705
2008
Homo sapiens (P29350)
Bhattacharya, S.; Labutti, J.N.; Seiner, D.R.; Gates, K.S.
Oxidative inactivation of protein tyrosine phosphatase 1B by organic hydroperoxides
Bioorg. Med. Chem. Lett.
18
5856-5859
2008
Homo sapiens
Wimmer-Kleikamp, S.H.; Nievergall, E.; Gegenbauer, K.; Adikari, S.; Mansour, M.; Yeadon, T.; Boyd, A.W.; Patani, N.R.; Lackmann, M.
Elevated protein tyrosine phosphatase activity provokes Eph/ephrin-facilitated adhesion of pre-B leukemia cells
Blood
112
721-732
2008
Homo sapiens
Kiyan, J.; Haller, H.; Dumler, I.
The tyrosine phosphatase SHP-2 controls urokinase-dependent signaling and functions in human vascular smooth muscle cells
Exp. Cell Res.
315
1029-1039
2008
Homo sapiens
Hendriks, W.J.; Elson, A.; Harroch, S.; Stoker, A.W.
Protein tyrosine phosphatases: functional inferences from mouse models and human diseases
FEBS J.
275
816-830
2008
Homo sapiens, Homo sapiens (O14522), Homo sapiens (P10586), Homo sapiens (P17706), Homo sapiens (P18031), Homo sapiens (P18433), Homo sapiens (P23467), Homo sapiens (P23468), Homo sapiens (P23469), Homo sapiens (P23470), Homo sapiens (P23471), Homo sapiens (P26045), Homo sapiens (P28827), Homo sapiens (P29074), Homo sapiens (P29350), Homo sapiens (P35236), Homo sapiens (P43378), Homo sapiens (P54829), Homo sapiens (Q05209), Homo sapiens (Q06124), Homo sapiens (Q0VAE8), Homo sapiens (Q12913), Homo sapiens (Q12923), Homo sapiens (Q13332), Homo sapiens (Q15256), Homo sapiens (Q15262), Homo sapiens (Q15678), Homo sapiens (Q16825), Homo sapiens (Q16827), Homo sapiens (Q16849), Homo sapiens (Q4JDK3), Homo sapiens (Q92729), Homo sapiens (Q92932), Homo sapiens (Q99952), Homo sapiens (Q9H3S7), Homo sapiens (Q9HD43), Homo sapiens (Q9UMZ3), Homo sapiens (Q9Y2R2)
Tabernero, L.; Aricescu, A.R.; Jones, E.Y.; Szedlacsek, S.E.
Protein tyrosine phosphatases: structure-function relationships
FEBS J.
275
867-882
2008
Homo sapiens, Yersinia sp.
Xu, D.; Qu, C.K.
Protein tyrosine phosphatases in the JAK/STAT pathway
Front. Biosci.
13
4925-4932
2008
Homo sapiens
Kakazu, A.; Sharma, G.; Bazan, H.E.
Association of protein tyrosine phosphatases (PTPs)-1B with c-Met receptor and modulation of corneal epithelial wound healing
Invest. Ophthalmol. Vis. Sci.
49
2927-2935
2008
Oryctolagus cuniculus, Homo sapiens
Carlucci, A.; Gedressi, C.; Lignitto, L.; Nezi, L.; Villa-Moruzzi, E.; Avvedimento, E.V.; Gottesman, M.; Garbi, C.; Feliciello, A.
Protein-tyrosine phosphatase PTPD1 regulates focal adhesion kinase autophosphorylation and cell migration
J. Biol. Chem.
283
10919-10929
2008
Homo sapiens
Welters, H.J.; Oknianska, A.; Erdmann, K.S.; Ryffel, G.U.; Morgan, N.G.
The protein tyrosine phosphatase-BL, modulates pancreatic beta-cell proliferation by interaction with the Wnt signalling pathway
J. Endocrinol.
197
543-552
2008
Homo sapiens
Lawrence, H.R.; Pireddu, R.; Chen, L.; Luo, Y.; Sung, S.S.; Szymanski, A.M.; Yip, M.L.; Guida, W.C.; Sebti, S.M.; Wu, J.; Lawrence, N.J.
Inhibitors of Src homology-2 domain containing protein tyrosine phosphatase-2 (Shp2) based on oxindole scaffolds
J. Med. Chem.
51
4948-4956
2008
Homo sapiens
Thuong, P.T.; Lee, C.H.; Dao, T.T.; Nguyen, P.H.; Kim, W.G.; Lee, S.J.; Oh, W.K.
Triterpenoids from the leaves of Diospyros kaki (persimmon) and their inhibitory effects on protein tyrosine phosphatase 1B
J. Nat. Prod.
71
1775-1778
2008
Homo sapiens
Allsup, D.; Harris, R.; Baker, P.; Cawley, J.
Protein-tyrosine phosphatase activity maintains the viability of hairy cells and modulates their response to interferon-alpha
Leuk. Lymphoma
49
2351-2358
2008
Homo sapiens
Kunnumakkara, A.B.; Nair, A.S.; Sung, B.; Pandey, M.K.; Aggarwal, B.B.
Boswellic acid blocks signal transducers and activators of transcription 3 signaling, proliferation, and survival of multiple myeloma via the protein tyrosine phosphatase SHP-1
Mol. Cancer Res.
7
118-128
2009
Homo sapiens
Chabot, C.; Spring, K.; Gratton, J.P.; Elchebly, M.; Royal, I.
New role for the protein tyrosine phosphatase DEP-1 in Akt activation and endothelial cell survival
Mol. Cell. Biol.
29
241-253
2009
Homo sapiens
Ishino, Y.; Zhu, C.; Harris, D.L.; Joyce, N.C.
Protein tyrosine phosphatase-1B (PTP1B) helps regulate EGF-induced stimulation of S-phase entry in human corneal endothelial cells
Mol. Vis.
14
61-70
2008
Homo sapiens
Choi, J.Y.; Na, M.; Hyun Hwang, I.; Ho Lee, S.; Young Bae, E.; Yeon Kim, B.; Seog Ahn, J.
Isolation of betulinic acid, its methyl ester and guaiane sesquiterpenoids with protein tyrosine phosphatase 1B inhibitory activity from the roots of Saussurea lappa C.B.Clarke
Molecules
14
266-272
2009
Homo sapiens
Gopishetty, B.; Ren, L.; Waller, T.M.; Wavreille, A.S.; Lopez, M.; Thakkar, A.; Zhu, J.; Pei, D.
Synthesis of 3,5-difluorotyrosine-containing peptides: application in substrate profiling of protein tyrosine phosphatases
Org. Lett.
10
4605-4608
2008
Homo sapiens
Kwon, J.H.; Chang, M.J.; Seo, H.W.; Lee, J.H.; Min, B.S.; Na, M.; Kim, J.C.; Woo, M.H.; Choi, J.S.; Lee, H.K.; Bae, K.
Triterpenoids and a sterol from the stem-bark of Styrax japonica and their protein tyrosine phosphatase 1B inhibitory activities
Phytother. Res.
22
1303-1306
2008
Homo sapiens
Hellmuth, K.; Grosskopf, S.; Lum, C.T.; Wuertele, M.; Roeder, N.; von Kries, J.P.; Rosario, M.; Rademann, J.; Birchmeier, W.
Specific inhibitors of the protein tyrosine phosphatase Shp2 identified by high-throughput docking
Proc. Natl. Acad. Sci. USA
105
7275-7280
2008
Homo sapiens
Boivin, B.; Zhang, S.; Arbiser, J.L.; Zhang, Z.Y.; Tonks, N.K.
A modified cysteinyl-labeling assay reveals reversible oxidation of protein tyrosine phosphatases in angiomyolipoma cells
Proc. Natl. Acad. Sci. USA
105
9959-9964
2008
Homo sapiens
Zhang, X.Y.; Bishop, A.C.
Engineered inhibitor sensitivity in the WPD loop of a protein tyrosine phosphatase
Biochemistry
47
4491-4500
2008
Homo sapiens (P17706)
Bustanji, Y.; Taha, M.O.; Al-Masri, I.M.; Mohammad, M.K.
Docking simulations and in vitro assay unveil potent inhibitory action of papaverine against protein tyrosine phosphatase 1B
Biol. Pharm. Bull.
32
640-645
2009
Homo sapiens (P18031), Homo sapiens
Seo, C.; Sohn, J.H.; Ahn, J.S.; Yim, J.H.; Lee, H.K.; Oh, H.
Protein tyrosine phosphatase 1B inhibitory effects of depsidone and pseudodepsidone metabolites from the Antarctic lichen Stereocaulon alpinum
Bioorg. Med. Chem. Lett.
19
2801-2803
2009
Homo sapiens
Yoon, G.; Lee, W.; Kim, S.N.; Cheon, S.H.
Inhibitory effect of chalcones and their derivatives from Glycyrrhiza inflata on protein tyrosine phosphatase 1B
Bioorg. Med. Chem. Lett.
19
5155-5157
2009
Homo sapiens
Seo, C.; Sohn, J.H.; Oh, H.; Kim, B.Y.; Ahn, J.S.
Isolation of the protein tyrosine phosphatase 1B inhibitory metabolite from the marine-derived fungus Cosmospora sp. SF-5060
Bioorg. Med. Chem. Lett.
19
6095-6097
2009
Homo sapiens
Qiu, W.W.; Shen, Q.; Yang, F.; Wang, B.; Zou, H.; Li, J.Y.; Li, J.; Tang, J.
Synthesis and biological evaluation of heterocyclic ring-substituted maslinic acid derivatives as novel inhibitors of protein tyrosine phosphatase 1B
Bioorg. Med. Chem. Lett.
19
6618-6622
2009
Homo sapiens
Forghieri, M.; Laggner, C.; Paoli, P.; Langer, T.; Manao, G.; Camici, G.; Bondioli, L.; Prati, F.; Costantino, L.
Synthesis, activity and molecular modeling of a new series of chromones as low molecular weight protein tyrosine phosphatase inhibitors
Bioorg. Med. Chem.
17
2658-2672
2009
Homo sapiens (P24666)
Ahn, K.S.; Sethi, G.; Sung, B.; Goel, A.; Ralhan, R.; Aggarwal, B.B.
Guggulsterone, a farnesoid X receptor antagonist, inhibits constitutive and inducible STAT3 activation through induction of a protein tyrosine phosphatase SHP-1
Cancer Res.
68
4406-4415
2008
Homo sapiens
Maccari, R.; Ottana, R.; Ciurleo, R.; Paoli, P.; Manao, G.; Camici, G.; Laggner, C.; Langer, T.
Structure-based optimization of benzoic acids as inhibitors of protein tyrosine phosphatase 1B and low molecular weight protein tyrosine phosphatase
ChemMedChem
4
957-962
2009
Homo sapiens (P18031)
Fukuda, S.; Ohta, T.; Sakata, S.; Morinaga, H.; Ito, M.; Nakagawa, Y.; Tanaka, M.; Matsushita, M.
Pharmacological profiles of a novel protein tyrosine phosphatase 1B inhibitor, JTT-551
Diabetes Obes. Metab.
12
299-306
2010
Homo sapiens, Mus musculus, Rattus norvegicus
Jung, S.K.; Jeong, D.G.; Chung, S.J.; Kim, J.H.; Park, B.C.; Tonks, N.K.; Ryu, S.E.; Kim, S.J.
Crystal structure of ED-Eya2: insight into dual roles as a protein tyrosine phosphatase and a transcription factor
FASEB J.
24
560-569
2010
Homo sapiens (O00167), Homo sapiens
Brandao, T.A.; Hengge, A.C.; Johnson, S.J.
Insights into the reaction of protein tyrosine phosphatase 1B. Crystal structures for transition-state analogs of both catalytic steps
J. Biol. Chem.
285
15874-15883
2010
Homo sapiens (P18031)
Yuan, C.; Lu, L.; Gao, X.; Wu, Y.; Guo, M.; Li, Y.; Fu, X.; Zhu, M.
Ternary oxovanadium(IV) complexes of ONO-donor Schiff base and polypyridyl derivatives as protein tyrosine phosphatase inhibitors: synthesis, characterization, and biological activities
J. Biol. Inorg. Chem.
14
841-851
2009
Homo sapiens
Fang, L.; Zhang, H.; Cui, W.; Ji, M.
Studies of the mechanism of selectivity of protein tyrosine phosphatase 1B (PTP1B) bidentate inhibitors using molecular dynamics simulations and free energy calculations
J. Chem. Inf. Model.
48
2030-2041
2008
Homo sapiens
Na, M.; Kim, B.Y.; Osada, H.; Ahn, J.S.
Inhibition of protein tyrosine phosphatase 1B by lupeol and lupenone isolated from Sorbus commixta
J. Enzyme Inhib. Med. Chem.
24
1056-1059
2009
Homo sapiens
Krishnamurthy, D.; Karver, M.R.; Fiorillo, E.; Orru, V.; Stanford, S.M.; Bottini, N.; Barrios, A.M.
Gold(I)-mediated inhibition of protein tyrosine phosphatases: a detailed in vitro and cellular study
J. Med. Chem.
51
4790-4795
2008
Homo sapiens, Yersinia enterolytica
Price, K.A.; Caragounis, A.; Paterson, B.M.; Filiz, G.; Volitakis, I.; Masters, C.L.; Barnham, K.J.; Donnelly, P.S.; Crouch, P.J.; White, A.R.
Sustained activation of glial cell epidermal growth factor receptor by bis(thiosemicarbazonato) metal complexes is associated with inhibition of protein tyrosine phosphatase activity
J. Med. Chem.
52
6606-6620
2009
Homo sapiens
Xi, G.; Shen, X.; Clemmons, D.R.
p66shc negatively regulates insulin-like growth factor I signal transduction via inhibition of p52shc binding to Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 leading to impaired growth factor receptor-bound protein-2 membrane
Mol. Endocrinol.
22
2162-2175
2008
Homo sapiens
Bae, D.; Camilli, T.C.; Chun, G.; Lal, M.; Wright, K.; OBrien, T.J.; Patierno, S.R.; Ceryak, S.
Bypass of hexavalent chromium-induced growth arrest by a protein tyrosine phosphatase inhibitor: enhanced survival and mutagenesis
Mutat. Res.
660
40-46
2009
Homo sapiens
Rodriguez-Ubreva, F.J.; Cariaga-Martinez, A.E.; Cortes, M.A.; Romero-De Pablos, M.; Ropero, S.; Lopez-Ruiz, P.; Colas, B.
Knockdown of protein tyrosine phosphatase SHP-1 inhibits G1/S progression in prostate cancer cells through the regulation of components of the cell-cycle machinery
Oncogene
29
345-355
2010
Homo sapiens
Dao, T.T.; Nguyen, P.H.; Thuong, P.T.; Kang, K.W.; Na, M.; Ndinteh, D.T.; Mbafor, J.T.; Oh, W.K.
Pterocarpans with inhibitory effects on protein tyrosine phosphatase 1B from Erythrina lysistemon Hutch
Phytochemistry
70
2053-2057
2009
Homo sapiens
Wang, V.; Davis, D.A.; Veeranna, R.P.; Haque, M.; Yarchoan, R.
Characterization of the activation of protein tyrosine phosphatase, receptor-type, Z polypeptide 1 (PTPRZ1) by hypoxia inducible factor-2 alpha
PLoS ONE
5
e9641
2010
Homo sapiens
Zhao, Y.; Zhang, X.; Guda, K.; Lawrence, E.; Sun, Q.; Watanabe, T.; Iwakura, Y.; Asano, M.; Wei, L.; Yang, Z.; Zheng, W.; Dawson, D.; Willis, J.; Markowitz, S.D.; Satake, M.; Wang, Z.
Identification and functional characterization of paxillin as a target of protein tyrosine phosphatase receptor T
Proc. Natl. Acad. Sci. USA
107
2592-2597
2010
Homo sapiens
Ren, L.; Chen, X.; Luechapanichkul, R.; Selner, N.G.; Meyer, T.M.; Wavreille, A.S.; Chan, R.; Iorio, C.; Zhou, X.; Neel, B.G.; Pei, D.
Substrate specificity of protein tyrosine phosphatases 1B, RPTPalpha, SHP-1, and SHP-2
Biochemistry
50
2339-2356
2011
Homo sapiens
Chia, J.Y.; Gajewski, J.E.; Xiao, Y.; Zhu, H.J.; Cheng, H.C.
Unique biochemical properties of the protein tyrosine phosphatase activity of PTEN-demonstration of different active site structural requirements for phosphopeptide and phospholipid phosphatase activities of PTEN
Biochim. Biophys. Acta
1804
1785-1795
2010
Homo sapiens
Liu, Z.; Lee, W.; Kim, S.N.; Yoon, G.; Cheon, S.H.
Design, synthesis, and evaluation of bromo-retrochalcone derivatives as protein tyrosine phosphatase 1B inhibitors
Bioorg. Med. Chem. Lett.
21
3755-3758
2011
Homo sapiens
Chen, V.L.; Bishop, A.C.
Chemical rescue of protein tyrosine phosphatase activity
Chem. Commun. (Camb. )
46
637-639
2010
Homo sapiens
Yu, X.; Chen, M.; Zhang, S.; Yu, Z.H.; Sun, J.P.; Wang, L.; Liu, S.; Imasaki, T.; Takagi, Y.; Zhang, Z.Y.
Substrate specificity of lymphoid-specific tyrosine phosphatase (Lyp) and identification of Src kinase-associated protein of 55 kDa homolog (SKAP-HOM) as a Lyp substrate
J. Biol. Chem.
286
30526-30534
2011
Homo sapiens
Ferrari, E.; Tinti, M.; Costa, S.; Corallino, S.; Nardozza, A.P.; Chatraryamontri, A.; Ceol, A.; Cesareni, G.; Castagnoli, L.
Identification of new substrates of the protein-tyrosine phosphatase PTP1B by Bayesian integration of proteome evidence
J. Biol. Chem.
286
4173-4185
2011
Homo sapiens
Wang, W.; Liu, L.; Song, X.; Mo, Y.; Komma, C.; Bellamy, H.D.; Zhao, Z.J.; Zhou, G.W.
Crystal structure of human protein tyrosine phosphatase SHP-1 in the open conformation
J. Cell. Biochem.
112
2062-2071
2011
Homo sapiens
Harris, L.K.; Frumm, S.M.; Bishop, A.C.
A general assay for monitoring the activities of protein tyrosine phosphatases in living eukaryotic cells
Anal. Biochem.
435
99-105
2013
Homo sapiens, Mus musculus
Mitra, A.; Sasikumar, K.; Parthasaradhi, B.V.; Radha, V.
The tyrosine phosphatase TC48 interacts with and inactivates the oncogenic fusion protein BCR-Abl but not cellular Abl
Biochim. Biophys. Acta
1832
275-284
2013
Homo sapiens (P17706), Homo sapiens
Meng, F.G.; Zhang, Z.Y.
Redox regulation of protein tyrosine phosphatase activity by hydroxyl radical
Biochim. Biophys. Acta
1834
464-469
2013
Homo sapiens
He, H.B.; Gao, L.X.; Deng, Q.F.; Ma, W.P.; Tang, C.L.; Qiu, W.W.; Tang, J.; Li, J.Y.; Li, J.; Yang, F.
Synthesis and biological evaluation of 4,4-dimethyl lithocholic acid derivatives as novel inhibitors of protein tyrosine phosphatase 1B
Bioorg. Med. Chem. Lett.
22
7237-7242
2012
Homo sapiens
Wang, Z.; Liu, Z.; Lee, W.; Kim, S.N.; Yoon, G.; Cheon, S.H.
Design, synthesis and docking study of 5-(substituted benzylidene)thiazolidine-2,4-dione derivatives as inhibitors of protein tyrosine phosphatase 1B
Bioorg. Med. Chem. Lett.
24
3337-3340
2014
Homo sapiens (P18031)
Zhi, Y.; Gao, L.X.; Jin, Y.; Tang, C.L.; Li, J.Y.; Li, J.; Long, Y.Q.
4-Quinolone-3-carboxylic acids as cell-permeable inhibitors of protein tyrosine phosphatase 1B
Bioorg. Med. Chem.
22
3670-3683
2014
Homo sapiens
Bellomo, E.; Massarotti, A.; Hogstrand, C.; Maret, W.
Zinc ions modulate protein tyrosine phosphatase 1B activity
Metallomics
6
1229-1239
2014
Homo sapiens (P18031), Homo sapiens
Yin, J.P.; Tang, C.L.; Gao, L.X.; Ma, W.P.; Li, J.Y.; Li, Y.; Li, J.; Nan, F.J.
Design and synthesis of paracaseolide A analogues as selective protein tyrosine phosphatase 1B inhibitors
Org. Biomol. Chem.
12
3441-3445
2014
Homo sapiens
Uddin, M.N.; Sharma, G.; Yang, J.L.; Choi, H.S.; Lim, S.I.; Kang, K.W.; Oh, W.K.
Oleanane triterpenes as protein tyrosine phosphatase 1B (PTP1B) inhibitors from Camellia japonica
Phytochemistry
103
99-106
2014
Homo sapiens
Li, S.; Zhang, J.; Lu, S.; Huang, W.; Geng, L.; Shen, Q.; Zhang, J.
The mechanism of allosteric inhibition of protein tyrosine phosphatase 1B
PLoS ONE
9
e97668
2014
Homo sapiens (P18031)
Bakke, J.; Haj, F.G.
Protein-tyrosine phosphatase 1B substrates and metabolic regulation
Semin. Cell Dev. Biol.
37
58-65
2015
Homo sapiens
Tanase, C.A.
Histidine domain-protein tyrosine phosphatase interacts with Grb2 and GrpL
PLoS ONE
5
e14339
2010
Homo sapiens
Lountos, G.; Kurussi, S.; Zhao, B.; Dyas, B.; Burke, T.J.; Ulrich, R.; Waugh, D.
High-resolution crystal structures of the D1 and D2 domains of protein tyrosine phosphatase epsilon for structure-based drug design
Acta Crystallogr. Sect. D
74
1015-1026
2018
Homo sapiens (P23469), Homo sapiens
Bishop, A.C.
A missense methionine mutation augments catalytic activity but reduces thermal stability in two protein tyrosine phosphatases
Biochem. Biophys. Res. Commun.
481
153-158
2016
Homo sapiens (P29350), Homo sapiens
Srinivasan, B.; Marks, H.; Mitra, S.; Smalley, D.M.; Skolnick, J.
Catalytic and substrate promiscuity distinct multiple chemistries catalysed by the phosphatase domain of receptor protein tyrosine phosphatase
Biochem. J.
473
2165-2177
2016
Homo sapiens (P23468), Homo sapiens (Q15256)
Tabernero, L.; Woodman, P.
Dissecting the role of His domain protein tyrosine phosphatase/PTPN23 and ESCRTs in sorting activated epidermal growth factor receptor to the multivesicular body
Biochem. Soc. Trans.
46
1037-1046
2018
Saccharomyces cerevisiae, Homo sapiens (Q9H3S7)
Hjortness, M.; Riccardi, L.; Hongdusit, A.; Ruppe, A.; Zhao, M.; Kim, E.; Zwart, P.; Sankaran, B.; Arthanari, H.; Sousa, M.; De Vivo, M.; Fox, J.
Abietane-type diterpenoids inhibit protein tyrosine phosphatases by stabilizing an inactive enzyme conformation
Biochemistry
57
5886-5896
2018
Homo sapiens (P18031)
-
Hengge, A.C.
Kinetic isotope effects in the characterization of catalysis by protein tyrosine phosphatases
Biochim. Biophys. Acta
1854
1768-1775
2015
Yersinia sp., Homo sapiens (P18031), Homo sapiens (P51452), Homo sapiens (Q9BVJ7), Mus musculus (P35821), Schizosaccharomyces pombe (P41893), Schizosaccharomyces pombe ATCC 24843 (P41893)
Zhang, L.; Ge, Y.; Song, H.M.; Wang, Q.M.; Zhou, C.H.
Design, synthesis of novel azolyl flavonoids and their protein tyrosine Phosphatase-1B inhibitory activities
Bioorg. Chem.
80
195-203
2018
Homo sapiens (P18031)
Peti, W.; Page, R.
Strategies to make protein serine/threonine (PP1, calcineurin) and tyrosine phosphatases (PTP1B) druggable Achieving specificity by targeting substrate and regulatory protein interaction sites
Bioorg. Med. Chem.
23
2781-2785
2015
Homo sapiens (P18031)
Korntner, S.; Pomorski, A.; Krezel, A.; Bishop, A.C.
Optimized allosteric inhibition of engineered protein tyrosine phosphatases with an expanded palette of biarsenical small molecules
Bioorg. Med. Chem.
26
2610-2620
2018
Homo sapiens (P18031)
Ge, L.; Li, K.S.; Li, M.M.; Xiao, P.; Hou, X.B.; Chen, X.; Liu, H.D.; Lin, A.; Yu, X.; Ren, G.J.; Fang, H.; Sun, J.P.
Identification of a benzo imidazole thiazole derivative as the specific irreversible inhibitor of protein tyrosine phosphatase
Bioorg. Med. Chem. Lett.
26
4795-4798
2016
Homo sapiens (P54829), Homo sapiens
Guerra, L.L.; Faccinetti, N.I.; Trabucchi, A.; Rovitto, B.D.; Sabljic, A.V.; Poskus, E.; Iacono, R.F.; Valdez, S.N.
Novel prokaryotic expression of thioredoxin-fused insulinoma associated protein tyrosine phosphatase 2 (IA-2), its characterization and immunodiagnostic application
BMC Biotechnol.
16
84
2016
Homo sapiens (Q16849)
Abdjul, D.B.; Yamazaki, H.; Kanno, S.I.; Kirikoshi, R.; Tomizawa, A.; Takahashi, O.; Maarisit, W.; Losung, F.; Rotinsulu, H.; Wewengkang, D.S.; Sumilat, D.A.; Kapojos, M.M.; Namikoshi, M.
Absolute structures of wedelolide derivatives and structure-activity relationships of protein tyrosine phosphatase 1B inhibitory ent-kaurene diterpenes from aerial parts of Wedelia spp. collected in Indonesia and Japan
Chem. Pharm. Bull.
66
682-687
2018
Homo sapiens (P18031), Homo sapiens
Ottana, R.; Paoli, P.; Nass, A.; Lori, G.; Cardile, V.; Adornato, I.; Rotondo, A.; Graziano, A.C.E.; Wolber, G.; Maccari, R.
Discovery of 4-[(5-arylidene-4-oxothiazolidin-3-yl)methyl]benzoic acid derivatives active as novel potent allosteric inhibitors of protein tyrosine phosphatase 1B in silico studies and in vitro evaluation as insulinomimetic and anti-inflammatory agents
Eur. J. Med. Chem.
127
840-858
2017
Homo sapiens (P18031)
Li, H.; Yang, D.; Ning, S.; Xu, Y.; Yang, F.; Yin, R.; Feng, T.; Han, S.; Guo, L.; Zhang, P.; Qu, W.; Guo, R.; Song, C.; Xiao, P.; Zhou, C.; Xu, Z.; Sun, J.P.; Yu, X.
Switching of the substrate specificity of protein tyrosine phosphatase N12 by cyclin-dependent kinase 2 phosphorylation orchestrating 2 oncogenic pathways
FASEB J.
32
73-82
2018
Homo sapiens (Q05209), Homo sapiens
Hon, J.; Hwang, M.S.; Charnetzki, M.A.; Rashed, I.J.; Brady, P.B.; Quillin, S.; Makinen, M.W.
Kinetic characterization of the inhibition of protein tyrosine phosphatase-1B by vanadyl (VO2+) chelates
J. Biol. Inorg. Chem.
22
1267-1279
2017
Homo sapiens (P18031)
Sarabia-Sanchez, M.J.; Trejo-Soto, P.J.; Velazquez-Lopez, J.M.; Carvente-Garcia, C.; Castillo, R.; Hernandez-Campos, A.; Avitia-Dominguez, C.; Enriquez-Mendiola, D.; Sierra-Campos, E.; Valdez-Solana, M.; Salas-Pacheco, J.M.; Tellez-Valencia, A.
Novel mixed-type inhibitors of protein tyrosine phosphatase 1B. Kinetic and computational studies
Molecules
22
2262-2278
2017
Homo sapiens (P18031)
Jiang, H.; Sui, Y.; Cui, Y.; Lin, P.; Li, W.; Xing, S.; Wang, D.; Hu, M.; Fu, X.
Expression, purification, and characterization of human osteoclastic protein-tyrosine phosphatase catalytic domain in Escherichia coli
Protein Expr. Purif.
107
7-12
2015
Homo sapiens (P23469), Homo sapiens
Parker, E.J.
The molecular basis for the substrate specificity of protein tyrosine phosphatase PTPN3
Structure
23
608-609
2015
Homo sapiens (P26045)
Chen, K.E.; Li, M.Y.; Chou, C.C.; Ho, M.R.; Chen, G.C.; Meng, T.C.; Wang, A.H.
Substrate specificity and plasticity of FERM-containing protein tyrosine phosphatases
Structure
23
653-664
2015
Homo sapiens (P18031), Homo sapiens (P26045), Homo sapiens (Q12923), Homo sapiens (Q15678), Homo sapiens (Q16825)
