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Literature summary for 3.1.3.48 extracted from

  • Lawrence, H.R.; Pireddu, R.; Chen, L.; Luo, Y.; Sung, S.S.; Szymanski, A.M.; Yip, M.L.; Guida, W.C.; Sebti, S.M.; Wu, J.; Lawrence, N.J.
    Inhibitors of Src homology-2 domain containing protein tyrosine phosphatase-2 (Shp2) based on oxindole scaffolds (2008), J. Med. Chem., 51, 4948-4956.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
(Z)-2-(2-(5-(N-(4-chloro-3-(trifluoromethyl)benzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid
-
Homo sapiens
(Z)-3-(2-(2-carboxyphenyl)hydrazono)-2-oxoindoline-5-carboxylic acid
-
Homo sapiens
(Z)-3-(2-(2-nitrophenyl)hydrazono)-2-oxoindoline-5-sulfonic acid NSC-117199 Homo sapiens
(Z)-3-(2-(3-carboxyphenyl)hydrazono)-2-oxoindoline-5-carboxylic acid
-
Homo sapiens
(Z)-3-(2-(5-(4-chlorobenzylcarbamoyl)-2-oxoindolin-3-ylidene)-hydrazinyl)benzoic acid
-
Homo sapiens
(Z)-3-(2-(5-(N-(2,4-dichlorophenethyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid
-
Homo sapiens
(Z)-3-(2-(5-(N-(2-chlorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid
-
Homo sapiens
(Z)-3-(2-(5-(N-(3-chloro-4-fluorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid
-
Homo sapiens
(Z)-3-(2-(5-(N-(3-chlorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid
-
Homo sapiens
(Z)-3-(2-(5-(N-(4-chloro-3-(trifluoromethyl)benzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid
-
Homo sapiens
(Z)-3-(2-(5-(N-(4-chlorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid
-
Homo sapiens
(Z)-3-(2-(5-(N-(4-fluorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid
-
Homo sapiens
(Z)-3-(2-(5-(N-(4-methylbenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid
-
Homo sapiens
(Z)-4-(2-(5-(N-(2-chlorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid
-
Homo sapiens
(Z)-4-(2-(5-(N-(4-chloro-3-(trifluoromethyl)benzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid
-
Homo sapiens
(Z)-4-(2-(5-(N-(4-chlorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid
-
Homo sapiens
(Z)-4-(2-(5-(N-(4-fluorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid
-
Homo sapiens
(Z)-4-(2-(5-(N-benzylsulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl) benzoic acid
-
Homo sapiens
3-[(2-nitrophenyl)hydrazono]-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide
-
Homo sapiens
3-[(2-nitrophenyl)hydrazono]-2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid 4-chlorobenzylamide
-
Homo sapiens
3-[N'-(5-isopropylsulfamoyl-2-oxo-1,2-dihydroindol-3-ylidene)-hydrazino]benzoic acid
-
Homo sapiens
4-[N'-(5-isopropylsulfamoyl-2-oxo-1,2-dihydroindol-3-ylidene)-hydrazino]benzoic acid
-
Homo sapiens
N,N'-[benzene-1,4-diylbis(propane-2,2-diylbenzene-4,1-diyl)]bis(1,1,1-trifluoromethanesulfonamide)
-
Homo sapiens
N-([4-[difluoro(phosphono)methyl]phenyl]acetyl)-a-aspartyl-4-[difluoro(phosphono)methyl]phenylalaninamide
-
Homo sapiens
NAT6-297775
-
Homo sapiens
NSC-87877 potent Shp2 and Shp1 inhibitor Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6,8-difluoro-4-methylumbelliferyl phosphate + H2O
-
Homo sapiens 6,8-difluoro-4-methylumbelliferol + phosphate
-
?
phosphorylated c-MET + H2O
-
Homo sapiens c-MET + phosphate
-
?
phosphorylated ErbB1 + H2O
-
Homo sapiens ErbB1 + phosphate
-
?
phosphorylated ErbB2 + H2O
-
Homo sapiens ErbB2 + phosphate
-
?

Synonyms

Synonyms Comment Organism
protein tyrosine phosphatase
-
Homo sapiens
protein tyrosine phosphatase 1B
-
Homo sapiens
PTP
-
Homo sapiens
PTP1B
-
Homo sapiens
SHP1
-
Homo sapiens
SHP2 Shp2 is a nonreceptor PTP that plays a positive role in cell signaling by growth factors and cytokines and is involved in regulation of cell proliferation, differentiation, and migration Homo sapiens
Src homology-2 domain containing protein tyrosine phosphatase-1
-
Homo sapiens
Src homology-2 domain containing protein tyrosine phosphatase-2
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0003
-
Shp2, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C Homo sapiens NSC-87877
0.0008
-
Shp2, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C Homo sapiens (Z)-3-(2-(2-carboxyphenyl)hydrazono)-2-oxoindoline-5-carboxylic acid
0.001
-
Shp2, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C Homo sapiens (Z)-3-(2-(5-(N-(4-fluorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid
0.0013
-
Shp2, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C Homo sapiens (Z)-4-(2-(5-(N-benzylsulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl) benzoic acid
0.0014
-
Shp2, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C Homo sapiens (Z)-3-(2-(5-(N-(4-chlorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid
0.0015
-
PTP1B, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C Homo sapiens (Z)-3-(2-(2-carboxyphenyl)hydrazono)-2-oxoindoline-5-carboxylic acid
0.0018
-
-
Homo sapiens N,N'-[benzene-1,4-diylbis(propane-2,2-diylbenzene-4,1-diyl)]bis(1,1,1-trifluoromethanesulfonamide)
0.0025
-
PTP1B, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C Homo sapiens (Z)-4-(2-(5-(N-benzylsulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl) benzoic acid
0.0025
-
Shp2, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C Homo sapiens NAT6-297775
0.0038
-
Shp2, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C Homo sapiens (Z)-3-(2-(5-(N-(3-chlorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid
0.0044
-
Shp2, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C Homo sapiens 3-[(2-nitrophenyl)hydrazono]-2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid 4-chlorobenzylamide
0.0045
-
Shp2, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C Homo sapiens 3-[N'-(5-isopropylsulfamoyl-2-oxo-1,2-dihydroindol-3-ylidene)-hydrazino]benzoic acid
0.0045
-
Shp2, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C Homo sapiens 4-[N'-(5-isopropylsulfamoyl-2-oxo-1,2-dihydroindol-3-ylidene)-hydrazino]benzoic acid
0.0048
-
Shp2, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C Homo sapiens (Z)-3-(2-(5-(N-(3-chloro-4-fluorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid
0.005
-
Shp2, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C Homo sapiens (Z)-3-(2-(5-(N-(4-methylbenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid
0.0052
-
Shp2, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C Homo sapiens (Z)-3-(2-(5-(N-(2,4-dichlorophenethyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid
0.0055
-
Shp2, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C Homo sapiens (Z)-3-(2-(5-(N-(2-chlorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid
0.0059
-
Shp2, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C Homo sapiens (Z)-4-(2-(5-(N-(4-chlorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid
0.0063
-
Shp2, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C Homo sapiens (Z)-4-(2-(5-(N-(4-fluorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid
0.0071
-
Shp1, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C Homo sapiens (Z)-4-(2-(5-(N-benzylsulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl) benzoic acid
0.0074
-
Shp2, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C Homo sapiens (Z)-4-(2-(5-(N-(2-chlorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid
0.0075
-
PTP1B, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C Homo sapiens (Z)-4-(2-(5-(N-(4-chlorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid
0.0083
-
Shp2, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C Homo sapiens (Z)-4-(2-(5-(N-(4-chloro-3-(trifluoromethyl)benzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid
0.0093
-
PTP1B, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C Homo sapiens 4-[N'-(5-isopropylsulfamoyl-2-oxo-1,2-dihydroindol-3-ylidene)-hydrazino]benzoic acid
0.0098
-
PTP1B, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C Homo sapiens 3-[(2-nitrophenyl)hydrazono]-2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid 4-chlorobenzylamide
0.01
-
-
Homo sapiens N-([4-[difluoro(phosphono)methyl]phenyl]acetyl)-a-aspartyl-4-[difluoro(phosphono)methyl]phenylalaninamide
0.0106
-
Shp2, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C Homo sapiens (Z)-3-(2-(5-(N-(4-chloro-3-(trifluoromethyl)benzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid
0.0108
-
Shp1, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C Homo sapiens (Z)-4-(2-(5-(N-(4-fluorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid
0.0113
-
PTP1B, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C Homo sapiens (Z)-3-(2-(5-(N-(4-methylbenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid
0.0114
-
PTP1B, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C Homo sapiens (Z)-4-(2-(5-(N-(4-fluorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid
0.0117
-
PTP1B, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C Homo sapiens (Z)-4-(2-(5-(N-(2-chlorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid
0.0119
-
Shp2, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C Homo sapiens 3-[(2-nitrophenyl)hydrazono]-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide
0.0145
-
PTP1B, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C Homo sapiens (Z)-3-(2-(5-(N-(4-fluorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid
0.0154
-
PTP1B, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C Homo sapiens (Z)-3-(2-(5-(N-(3-chlorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid
0.0154
-
Shp1, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C Homo sapiens (Z)-3-(2-(2-carboxyphenyl)hydrazono)-2-oxoindoline-5-carboxylic acid
0.0157
-
Shp1, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C Homo sapiens 3-[N'-(5-isopropylsulfamoyl-2-oxo-1,2-dihydroindol-3-ylidene)-hydrazino]benzoic acid
0.0158
-
Shp2, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C Homo sapiens (Z)-3-(2-(3-carboxyphenyl)hydrazono)-2-oxoindoline-5-carboxylic acid
0.0159
-
Shp1, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C Homo sapiens (Z)-3-(2-(5-(N-(2-chlorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid
0.018
-
Shp1, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C Homo sapiens (Z)-3-(2-(5-(N-(4-chlorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid
0.0181
-
Shp1, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C Homo sapiens (Z)-4-(2-(5-(N-(4-chlorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid
0.0183
-
Shp1, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C Homo sapiens (Z)-3-(2-(5-(N-(4-fluorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid
0.0188
-
PTP1B, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C Homo sapiens (Z)-3-(2-(5-(N-(4-chlorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid
0.0193
-
PTP1B, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C Homo sapiens (Z)-3-(2-(5-(N-(2,4-dichlorophenethyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid
0.0194
-
PTP1B, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C Homo sapiens (Z)-3-(2-(5-(N-(2-chlorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid
0.0194
-
Shp1, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C Homo sapiens (Z)-3-(2-(5-(4-chlorobenzylcarbamoyl)-2-oxoindolin-3-ylidene)-hydrazinyl)benzoic acid
0.0223
-
Shp2, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C Homo sapiens (Z)-3-(2-(5-(4-chlorobenzylcarbamoyl)-2-oxoindolin-3-ylidene)-hydrazinyl)benzoic acid
0.0229
-
Shp2, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C Homo sapiens (Z)-2-(2-(5-(N-(4-chloro-3-(trifluoromethyl)benzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid
0.0257
-
PTP1B, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C Homo sapiens (Z)-2-(2-(5-(N-(4-chloro-3-(trifluoromethyl)benzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid
0.0277
-
Shp1, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C Homo sapiens 4-[N'-(5-isopropylsulfamoyl-2-oxo-1,2-dihydroindol-3-ylidene)-hydrazino]benzoic acid
0.0324
-
Shp1, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C Homo sapiens (Z)-2-(2-(5-(N-(4-chloro-3-(trifluoromethyl)benzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid
0.0326
-
Shp1, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C Homo sapiens (Z)-3-(2-(5-(N-(4-methylbenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid
0.0328
-
PTP1B, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C Homo sapiens (Z)-4-(2-(5-(N-(4-chloro-3-(trifluoromethyl)benzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid
0.0371
-
PTP1B, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C Homo sapiens 3-[N'-(5-isopropylsulfamoyl-2-oxo-1,2-dihydroindol-3-ylidene)-hydrazino]benzoic acid
0.0382
-
PTP1B, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C Homo sapiens (Z)-3-(2-(3-carboxyphenyl)hydrazono)-2-oxoindoline-5-carboxylic acid
0.0409
-
Shp1, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C Homo sapiens 3-[(2-nitrophenyl)hydrazono]-2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid 4-chlorobenzylamide
0.0425
-
Shp1, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C Homo sapiens (Z)-3-(2-(5-(N-(3-chlorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid
0.0431
-
Shp1, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C Homo sapiens (Z)-4-(2-(5-(N-(4-chloro-3-(trifluoromethyl)benzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid
0.0468
-
Shp2, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C Homo sapiens (Z)-3-(2-(2-nitrophenyl)hydrazono)-2-oxoindoline-5-sulfonic acid
0.0549
-
PTP1B, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C Homo sapiens (Z)-3-(2-(5-(N-(3-chloro-4-fluorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid
0.0608
-
Shp1, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C Homo sapiens (Z)-4-(2-(5-(N-(2-chlorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid
0.0631
-
PTP1B, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C Homo sapiens (Z)-3-(2-(5-(N-(4-chloro-3-(trifluoromethyl)benzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid
0.068
-
Shp1, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C Homo sapiens (Z)-3-(2-(2-nitrophenyl)hydrazono)-2-oxoindoline-5-sulfonic acid
0.0724
-
Shp1, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C Homo sapiens (Z)-3-(2-(3-carboxyphenyl)hydrazono)-2-oxoindoline-5-carboxylic acid
0.0734
-
Shp1, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C Homo sapiens (Z)-3-(2-(5-(N-(2,4-dichlorophenethyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid
0.0742
-
Shp1, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C Homo sapiens (Z)-3-(2-(5-(N-(4-chloro-3-(trifluoromethyl)benzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid
0.0967
-
PTP1B, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C Homo sapiens (Z)-3-(2-(2-nitrophenyl)hydrazono)-2-oxoindoline-5-sulfonic acid
0.1037
-
Shp1, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C Homo sapiens 3-[(2-nitrophenyl)hydrazono]-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide
0.1228
-
Shp1, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C Homo sapiens (Z)-3-(2-(5-(N-(3-chloro-4-fluorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid
0.1566
-
PTP1B, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C Homo sapiens 3-[(2-nitrophenyl)hydrazono]-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide
0.3
-
IC50 above 0.3 mM, PTP1B, in 25 mM MOPS (pH 7.0), 50 mM NaCl, 0.05% (v/v) Tween 20, 1 mM dithiothreitol, at 25°C Homo sapiens (Z)-3-(2-(5-(4-chlorobenzylcarbamoyl)-2-oxoindolin-3-ylidene)-hydrazinyl)benzoic acid