Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(4aS,6aS,6bR,14aR)-2,2,6a,6b,9,9,14a-heptamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,14,14a,14b,15,16b-hexadecahydrochryseno[1,2-g]quinazoline-4a(2H)-carboxylic acid | no inhibition of LMW-PTP isozymes, but 20% inhibition of PTP-B1 at 0.02 mM | Homo sapiens | |
2',4'-dihydroxy-1,1'-biphenyl | - |
Homo sapiens | |
2-(4-hydroxyphenyl)-3-[(3,4-dihydroxy-1,1'-biphenyl-4-yl)methyl]-4H-1-benzopyran-4-one | - |
Homo sapiens | |
2-(4-hydroxyphenyl)-3-[(4-carboxy-3-hydroxy-1,1'-biphenyl-4-yl)methyl]-4H-1-benzopyran-4-one | - |
Homo sapiens | |
3',4'-dihydroxy-1,1'-biphenyl | no inhibition of LMW-PTP isozymes, but 5% inhibition of PTP-B1 at 0.02 mM | Homo sapiens | |
3-(biphenyl-4-ylmethyl)-6-hydroxy-2-(4-hydroxybenzyl)-4H-chromen-4-one | - |
Homo sapiens | |
3-benzyl-7-hydroxy-2-(4-hydroxybenzyl)-4H-chromen-4-one | 10% inhibition of LMW-PTP isozymes 1 and 2,no inhibition of PTP-B1, at 0.015 mM | Homo sapiens | |
4'-carboxy-3'-hydroxy-1,1'-biphenyl | no inhibition of LMW-PTP isozymes, but 10% inhibition of PTP-B1 at 0.02 mM | Homo sapiens | |
4'-[(2-butyl-1-benzofuran-3-yl)methyl]biphenyl-4-ol | - |
Homo sapiens | |
4'-[2-(4-hydroxybutyl)-1-benzofuran-3-yl]biphenyl-4-ol | - |
Homo sapiens | |
6,7-dihydroxy-2-(4-hydroxyphenyl)-3-[(1,1-biphenyl-4-yl)methyl]-4H-1-benzopyran-4-one | - |
Homo sapiens | |
6-hydroxy-2-(4-hydroxybenzyl)-3-[(1,1-biphenyl-4-yl)methyl]-4H-1-benzopyran-4-one | 20% inhibition of PTP-B1 at 0.015 mM | Homo sapiens | |
7-hydroxy-2-(4'-hydroxyphenyl)-3-[(1,1'-biphenyl-4-yl)methyl]-4H-1-benzopyran-4-one | - |
Homo sapiens | |
7-hydroxy-2-(4'-hydroxyphenyl)-3-[(3'',4''-dihydroxy-1,1'-biphenyl-4-yl)methyl]-4H-1-benzopyran-4-one | - |
Homo sapiens | |
7-hydroxy-2-(4'-hydroxyphenyl)-3-[(3''-carboxy-1,1'-biphenyl-4-yl)methyl]-4H-1-benzopyran-4-one | - |
Homo sapiens | |
7-hydroxy-2-(4'-hydroxyphenyl)-3-[(4''-carboxy-3''-hydroxy-1,1'-biphenyl-4-yl)methyl]-4H-1-benzopyran-4-one | - |
Homo sapiens | |
7-hydroxy-2-(4'-hydroxyphenyl)-3-[(4''-hydroxy-1,1'-biphenyl-4-yl)methyl]-4H-1-benzopyran-4-one | - |
Homo sapiens | |
7-hydroxy-2-(4-hydroxybenzyl)-4H-chromen-4-one | 10% inhibition of LMW-PTP isozymes 1 and 2,no inhibition of PTP-B1, at 0.015 mM | Homo sapiens | |
7-hydroxy-2-(4-hydroxyphenyl)-3-[(3',4'-dihydroxy-1,1-biphenyl-3-yl)methyl]-4H-1-benzopyran-4-one | 60% inhibition of LMW-PTP isozyme 2, 25% inhibition of LMW-PTP 1, and 50% inhibition of PTP-B1, at 0.02 mM | Homo sapiens | |
7-hydroxy-2-(4-hydroxyphenyl)-3-[(4'-carboxy-3'-hydroxy-1,1-biphenyl-3-yl)methyl]-4H-1-benzopyran-4-one | 5% inhibition of LMW-PTP isozyme 2, 10% inhibition of LMW-PTP 1, and 59% inhibition of PTP-B1, at 0.02 mM | Homo sapiens | |
7-hydroxy-2-(4-hydroxyphenylethyl)-3-[(1,1-biphenyl-4-yl)methyl]-4H-1-benzopyran-4-one | 20% inhibition of PTP-B1 at 0.015 mM | Homo sapiens | |
7-hydroxy-2-(4-hydroxyphenylmethyl)-3-[(1,1'-biphenyl-4-yl)methyl]-4H-1-benzopyran-4-one | 10% inhibition of PTP-B1 at 0.015 mM | Homo sapiens | |
7-hydroxy-2-(4-hydroxyphenylpropyl)-3-[(1,1'-biphenyl-4-yl)methyl]-4H-1-benzopyran-4-one | 10% inhibition of LMW-PTP isozymes 1 and 2,no inhibition of PTP-B1, at 0.015 mM | Homo sapiens | |
biphenyl-3,4-diol | 25% inhibition of LMW-PTP isozyme 2, and 10% inhibition of LMW-PTP 1 and PTP-B1 at 0.02 mM | Homo sapiens | |
[[4'-(2-butyl-1-benzofuran-3-yl)biphenyl-4-yl]oxy]acetic acid | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P24666 | two isozymes of LMW-PTP, and PTP-1B | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-nitrophenyl phosphate + H2O | - |
Homo sapiens | 4-nitrophenol + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
LMW-PTP | - |
Homo sapiens |
More | the enzyme belongs to the LMW-PTP family | Homo sapiens |
protein tyrosine phosphatase | - |
Homo sapiens |
PTP | - |
Homo sapiens |
PTP-1B | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
assay at | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0007 | - |
pH 7.0, 37°C, LMW-PTP isozyme 1 | Homo sapiens | 2-(4-hydroxyphenyl)-3-[(4-carboxy-3-hydroxy-1,1'-biphenyl-4-yl)methyl]-4H-1-benzopyran-4-one | |
0.00074 | - |
pH 7.0, 37°C, PTP-B1 | Homo sapiens | 2',4'-dihydroxy-1,1'-biphenyl | |
0.0009 | - |
pH 7.0, 37°C, PTP-B1 | Homo sapiens | 2-(4-hydroxyphenyl)-3-[(4-carboxy-3-hydroxy-1,1'-biphenyl-4-yl)methyl]-4H-1-benzopyran-4-one | |
0.001 | - |
pH 7.0, 37°C, PTP-B1 | Homo sapiens | 7-hydroxy-2-(4'-hydroxyphenyl)-3-[(4''-carboxy-3''-hydroxy-1,1'-biphenyl-4-yl)methyl]-4H-1-benzopyran-4-one | |
0.00108 | - |
pH 7.0, 37°C, PTP-B2 | Homo sapiens | 4'-[2-(4-hydroxybutyl)-1-benzofuran-3-yl]biphenyl-4-ol | |
0.0011 | - |
pH 7.0, 37°C, LMW-PTP isozyme 1 | Homo sapiens | 6,7-dihydroxy-2-(4-hydroxyphenyl)-3-[(1,1-biphenyl-4-yl)methyl]-4H-1-benzopyran-4-one | |
0.00119 | - |
pH 7.0, 37°C, PTP-B3 | Homo sapiens | 4'-[(2-butyl-1-benzofuran-3-yl)methyl]biphenyl-4-ol | |
0.0013 | - |
pH 7.0, 37°C, LMW-PTP isozyme 1 | Homo sapiens | 7-hydroxy-2-(4'-hydroxyphenyl)-3-[(4''-carboxy-3''-hydroxy-1,1'-biphenyl-4-yl)methyl]-4H-1-benzopyran-4-one | |
0.002 | - |
pH 7.0, 37°C, PTP-B1 | Homo sapiens | 6,7-dihydroxy-2-(4-hydroxyphenyl)-3-[(1,1-biphenyl-4-yl)methyl]-4H-1-benzopyran-4-one | |
0.00219 | - |
pH 7.0, 37°C, PTP-B4 | Homo sapiens | [[4'-(2-butyl-1-benzofuran-3-yl)biphenyl-4-yl]oxy]acetic acid | |
0.0022 | - |
pH 7.0, 37°C, LMW-PTP isozyme 2 | Homo sapiens | 7-hydroxy-2-(4'-hydroxyphenyl)-3-[(4''-carboxy-3''-hydroxy-1,1'-biphenyl-4-yl)methyl]-4H-1-benzopyran-4-one | |
0.003 | - |
pH 7.0, 37°C, LMW-PTP isozyme 2 | Homo sapiens | 6,7-dihydroxy-2-(4-hydroxyphenyl)-3-[(1,1-biphenyl-4-yl)methyl]-4H-1-benzopyran-4-one | |
0.005 | - |
pH 7.0, 37°C, PTP-B1 | Homo sapiens | 2-(4-hydroxyphenyl)-3-[(3,4-dihydroxy-1,1'-biphenyl-4-yl)methyl]-4H-1-benzopyran-4-one | |
0.0053 | - |
pH 7.0, 37°C, LMW-PTP isozyme 1 | Homo sapiens | 7-hydroxy-2-(4-hydroxyphenylmethyl)-3-[(1,1'-biphenyl-4-yl)methyl]-4H-1-benzopyran-4-one | |
0.0057 | - |
pH 7.0, 37°C, LMW-PTP isozyme 2 | Homo sapiens | 2-(4-hydroxyphenyl)-3-[(4-carboxy-3-hydroxy-1,1'-biphenyl-4-yl)methyl]-4H-1-benzopyran-4-one | |
0.0062 | - |
pH 7.0, 37°C, PTP-B1 | Homo sapiens | 7-hydroxy-2-(4'-hydroxyphenyl)-3-[(3''-carboxy-1,1'-biphenyl-4-yl)methyl]-4H-1-benzopyran-4-one | |
0.0065 | - |
pH 7.0, 37°C, LMW-PTP isozyme 1 | Homo sapiens | 7-hydroxy-2-(4-hydroxyphenylethyl)-3-[(1,1-biphenyl-4-yl)methyl]-4H-1-benzopyran-4-one | |
0.0074 | - |
pH 7.0, 37°C, LMW-PTP isozyme 1 | Homo sapiens | 7-hydroxy-2-(4'-hydroxyphenyl)-3-[(3'',4''-dihydroxy-1,1'-biphenyl-4-yl)methyl]-4H-1-benzopyran-4-one | |
0.0077 | - |
pH 7.0, 37°C, PTP-B1 | Homo sapiens | 7-hydroxy-2-(4'-hydroxyphenyl)-3-[(3'',4''-dihydroxy-1,1'-biphenyl-4-yl)methyl]-4H-1-benzopyran-4-one | |
0.0082 | - |
pH 7.0, 37°C, LMW-PTP isozyme 1 | Homo sapiens | 7-hydroxy-2-(4'-hydroxyphenyl)-3-[(4''-hydroxy-1,1'-biphenyl-4-yl)methyl]-4H-1-benzopyran-4-one | |
0.0086 | - |
pH 7.0, 37°C, LMW-PTP isozyme 1 | Homo sapiens | 6-hydroxy-2-(4-hydroxybenzyl)-3-[(1,1-biphenyl-4-yl)methyl]-4H-1-benzopyran-4-one | |
0.0114 | - |
pH 7.0, 37°C, LMW-PTP isozyme 1 | Homo sapiens | 7-hydroxy-2-(4'-hydroxyphenyl)-3-[(3''-carboxy-1,1'-biphenyl-4-yl)methyl]-4H-1-benzopyran-4-one | |
0.0124 | - |
pH 7.0, 37°C, LMW-PTP isozyme 2 | Homo sapiens | 7-hydroxy-2-(4'-hydroxyphenyl)-3-[(3'',4''-dihydroxy-1,1'-biphenyl-4-yl)methyl]-4H-1-benzopyran-4-one | |
0.0126 | - |
pH 7.0, 37°C, LMW-PTP isozyme 2 | Homo sapiens | 2-(4-hydroxyphenyl)-3-[(3,4-dihydroxy-1,1'-biphenyl-4-yl)methyl]-4H-1-benzopyran-4-one | |
0.0143 | - |
pH 7.0, 37°C, LMW-PTP isozyme 1 | Homo sapiens | 2-(4-hydroxyphenyl)-3-[(3,4-dihydroxy-1,1'-biphenyl-4-yl)methyl]-4H-1-benzopyran-4-one | |
0.017 | - |
pH 7.0, 37°C, PTP-B1 | Homo sapiens | 7-hydroxy-2-(4'-hydroxyphenyl)-3-[(4''-hydroxy-1,1'-biphenyl-4-yl)methyl]-4H-1-benzopyran-4-one | |
0.0172 | - |
pH 7.0, 37°C, LMW-PTP isozyme 2 | Homo sapiens | 6-hydroxy-2-(4-hydroxybenzyl)-3-[(1,1-biphenyl-4-yl)methyl]-4H-1-benzopyran-4-one | |
0.0173 | - |
pH 7.0, 37°C, LMW-PTP isozyme 2 | Homo sapiens | 7-hydroxy-2-(4-hydroxyphenylethyl)-3-[(1,1-biphenyl-4-yl)methyl]-4H-1-benzopyran-4-one | |
0.0175 | - |
pH 7.0, 37°C, LMW-PTP isozyme 2 | Homo sapiens | 7-hydroxy-2-(4-hydroxyphenylmethyl)-3-[(1,1'-biphenyl-4-yl)methyl]-4H-1-benzopyran-4-one | |
0.0184 | - |
pH 7.0, 37°C, LMW-PTP isozyme 2 | Homo sapiens | 7-hydroxy-2-(4'-hydroxyphenyl)-3-[(4''-hydroxy-1,1'-biphenyl-4-yl)methyl]-4H-1-benzopyran-4-one | |
0.0268 | - |
pH 7.0, 37°C, LMW-PTP isozyme 2 | Homo sapiens | 7-hydroxy-2-(4'-hydroxyphenyl)-3-[(3''-carboxy-1,1'-biphenyl-4-yl)methyl]-4H-1-benzopyran-4-one |
General Information | Comment | Organism |
---|---|---|
physiological function | protein tyrosine phosphatases are crucial elements in eukaryotic signal transduction | Homo sapiens |