Protein Variants | Comment | Organism |
---|---|---|
additional information | knockdown of SHP-1 inhibits G1/S progression in prostate cancer cells through the regulation of components of the cell-cycle machinery. SHP-1 depletion in PC-3 cells induces by small interfering RNAs causes G1 phase cell-cycle arrest accompanied by changes in some components of the cellcycle machinery. SHP-1 knockdown increases p27Kip1 protein stability, its nuclear localization and p27 gene transcription. SHP-1 knockdown decreases the CDK6 levels, inducing retinoblastoma protein hypophosphorylation, downregulation of cyclin E and thereby a decrease in the CDK2 activity. Phenotype, overview | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hematopoietic cell | SHP-1 is a hematopoietic cell-specific tyrosine phosphatase | Homo sapiens | - |
PC-3 cell | - |
Homo sapiens | - |
prostate epithelium | - |
Homo sapiens | - |
Subunits | Comment | Organism |
---|---|---|
More | SHP-1 contains two N-terminal-located SH2 domains | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
protein tyrosine phosphatase | - |
Homo sapiens |
SHP-1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | SHP-1 is involved in the PI3K-AKT pathway interacting with PI3K and regulating its activity and p110 catalytic subunit phosphorylation | Homo sapiens |