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Literature summary for 3.1.3.48 extracted from

  • Rodriguez-Ubreva, F.J.; Cariaga-Martinez, A.E.; Cortes, M.A.; Romero-De Pablos, M.; Ropero, S.; Lopez-Ruiz, P.; Colas, B.
    Knockdown of protein tyrosine phosphatase SHP-1 inhibits G1/S progression in prostate cancer cells through the regulation of components of the cell-cycle machinery (2010), Oncogene, 29, 345-355.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information knockdown of SHP-1 inhibits G1/S progression in prostate cancer cells through the regulation of components of the cell-cycle machinery. SHP-1 depletion in PC-3 cells induces by small interfering RNAs causes G1 phase cell-cycle arrest accompanied by changes in some components of the cellcycle machinery. SHP-1 knockdown increases p27Kip1 protein stability, its nuclear localization and p27 gene transcription. SHP-1 knockdown decreases the CDK6 levels, inducing retinoblastoma protein hypophosphorylation, downregulation of cyclin E and thereby a decrease in the CDK2 activity. Phenotype, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Homo sapiens 5829
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hematopoietic cell SHP-1 is a hematopoietic cell-specific tyrosine phosphatase Homo sapiens
-
PC-3 cell
-
Homo sapiens
-
prostate epithelium
-
Homo sapiens
-

Subunits

Subunits Comment Organism
More SHP-1 contains two N-terminal-located SH2 domains Homo sapiens

Synonyms

Synonyms Comment Organism
protein tyrosine phosphatase
-
Homo sapiens
SHP-1
-
Homo sapiens

General Information

General Information Comment Organism
physiological function SHP-1 is involved in the PI3K-AKT pathway interacting with PI3K and regulating its activity and p110 catalytic subunit phosphorylation Homo sapiens