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Literature summary for 3.1.3.48 extracted from

  • Thuong, P.T.; Lee, C.H.; Dao, T.T.; Nguyen, P.H.; Kim, W.G.; Lee, S.J.; Oh, W.K.
    Triterpenoids from the leaves of Diospyros kaki (persimmon) and their inhibitory effects on protein tyrosine phosphatase 1B (2008), J. Nat. Prod., 71, 1775-1778.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
19alpha,24-dihydroxyurs-12-en-3-on-28-oic acid
-
Homo sapiens
24-hydroxyursolic acid
-
Homo sapiens
additional information 3alpha,24,29-trihydroxyolean-12-en-28-oic acid, 3alpha,19alpha-dihydroxyurs-12,20(30)-dien-24,28-dioic acid, and 3alpha,19alpha-dihydroxyurs-12-en-24,28-dioic acid show very weak inhibitory effect towards PTP1B Homo sapiens
oleanolic acid
-
Homo sapiens
oleanonic acid
-
Homo sapiens
pomolic acid
-
Homo sapiens
RK-682
-
Homo sapiens
rotungenic acid
-
Homo sapiens
spathodic acid
-
Homo sapiens
ursolic acid
-
Homo sapiens
uvaol
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphorylated phospholipase Cgamma + H2O dephosphorylation occurs at Tyr-783 Homo sapiens phospholipase Cgamma + phosphate
-
?

Synonyms

Synonyms Comment Organism
protein tyrosine phosphatase 1B
-
Homo sapiens
PTP1B
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0031
-
-
Homo sapiens ursolic acid
0.0035
-
-
Homo sapiens oleanonic acid
0.0039
-
-
Homo sapiens pomolic acid
0.0041
-
-
Homo sapiens RK-682
0.0076
-
-
Homo sapiens oleanolic acid
0.0081
-
-
Homo sapiens 19alpha,24-dihydroxyurs-12-en-3-on-28-oic acid
0.0109
-
-
Homo sapiens rotungenic acid
0.0128
-
-
Homo sapiens 24-hydroxyursolic acid
0.0156
-
-
Homo sapiens uvaol
0.0188
-
-
Homo sapiens spathodic acid