Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Cr(VI) | as Na2CrO4, induces clonogenic lethality | Homo sapiens | |
sodium orthovanadate | a broad-range PTP inhibitor, abrogated Cr(VI)-induced clonogenic lethality | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fibroblast | lung | Homo sapiens | - |
LL24 cell | - |
Homo sapiens | - |
lung | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
protein tyrosine phosphatase | - |
Homo sapiens |
PTP | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | PTPs are integral components of key cell survival pathways, and are responsible for their inactivation, while PTP inhibition is are often associated with enhanced cell proliferation, overview. PTP inhibition in the presence of certain types of DNA damage may lead to increased genomic instability, via bypass of cell cycle checkpoints | Homo sapiens |
physiological function | PTPs are integral components of key cell survival pathways, and are responsible for their inactivation, while PTP inhibition is are often associated with enhanced cell proliferation, overview | Homo sapiens |