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Literature summary for 3.1.3.48 extracted from

  • Uddin, M.N.; Sharma, G.; Yang, J.L.; Choi, H.S.; Lim, S.I.; Kang, K.W.; Oh, W.K.
    Oleanane triterpenes as protein tyrosine phosphatase 1B (PTP1B) inhibitors from Camellia japonica (2014), Phytochemistry, 103, 99-106.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(3beta)-3-(acetyloxy)olean-12-en-28-oic acid
-
Homo sapiens
(3beta)-3-hydroxyolean-12-en-28-oic acid
-
Homo sapiens
(3beta)-3-hydroxyoleana-11,13(18)-dien-28-oic acid
-
Homo sapiens
(4aR,6aR,6bS,8aR,12aS,14aR,14bR)-8a-hydroxy-4,4,6a,6b,11,11,14b-heptamethyl-1,4a,5,6,6a,6b,7,8a,9,10,11,12,12a,14,14a,14b-hexadecahydropicene-3,8(2H,4H)-dione
-
Homo sapiens
(4aR,6aS,6bR,8aR,10S,12aR,12bR,14bS)-4a,10-dihydroxy-2,2,6a,6b,9,9,12a-heptamethyl-2,3,4,4a,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydropicen-5(1H)-one
-
Homo sapiens
(6aS,6bR,8aR,10S,12aS,12bR)-10-hydroxy-2,2,6a,6b,9,9,12a-heptamethyl-2,3,4,4a,6,6a,6b,7,8,8a,9,10,11,12,12a,12b-hexadecahydropicen-5(1H)-one
-
Homo sapiens
3,16-dioxo-olean-12(13),17(18)-diene
-
Homo sapiens
3beta,16a,17-trihydroxy-olean-12-ene
-
Homo sapiens
additional information not inhibited by camelliaolean A and camelliaolean B Homo sapiens
ursolic acid
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[a protein]-tyrosine phosphate + H2O Homo sapiens
-
[a protein]-tyrosine + phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrophenyl phosphate + H2O
-
Homo sapiens 4-nitrophenol + phosphate
-
?
[a protein]-tyrosine phosphate + H2O
-
Homo sapiens [a protein]-tyrosine + phosphate
-
?

Synonyms

Synonyms Comment Organism
protein tyrosine phosphatase 1B
-
Homo sapiens
PTP1B
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00374
-
in 50 mM citrate (pH 6.0), 1 mM dithiothreitol, 1 mM EDTA, and 0.1 M NaCl, at 37°C Homo sapiens ursolic acid
0.00377
-
in 50 mM citrate (pH 6.0), 1 mM dithiothreitol, 1 mM EDTA, and 0.1 M NaCl, at 37°C Homo sapiens (4aR,6aS,6bR,8aR,10S,12aR,12bR,14bS)-4a,10-dihydroxy-2,2,6a,6b,9,9,12a-heptamethyl-2,3,4,4a,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydropicen-5(1H)-one
0.00394
-
in 50 mM citrate (pH 6.0), 1 mM dithiothreitol, 1 mM EDTA, and 0.1 M NaCl, at 37°C Homo sapiens 3beta,16a,17-trihydroxy-olean-12-ene
0.00466
-
in 50 mM citrate (pH 6.0), 1 mM dithiothreitol, 1 mM EDTA, and 0.1 M NaCl, at 37°C Homo sapiens (6aS,6bR,8aR,10S,12aS,12bR)-10-hydroxy-2,2,6a,6b,9,9,12a-heptamethyl-2,3,4,4a,6,6a,6b,7,8,8a,9,10,11,12,12a,12b-hexadecahydropicen-5(1H)-one
0.00479
-
in 50 mM citrate (pH 6.0), 1 mM dithiothreitol, 1 mM EDTA, and 0.1 M NaCl, at 37°C Homo sapiens (3beta)-3-(acetyloxy)olean-12-en-28-oic acid
0.00534
-
in 50 mM citrate (pH 6.0), 1 mM dithiothreitol, 1 mM EDTA, and 0.1 M NaCl, at 37°C Homo sapiens (3beta)-3-hydroxyolean-12-en-28-oic acid
0.0064
-
in 50 mM citrate (pH 6.0), 1 mM dithiothreitol, 1 mM EDTA, and 0.1 M NaCl, at 37°C Homo sapiens (3beta)-3-hydroxyoleana-11,13(18)-dien-28-oic acid
0.01623
-
in 50 mM citrate (pH 6.0), 1 mM dithiothreitol, 1 mM EDTA, and 0.1 M NaCl, at 37°C Homo sapiens 3,16-dioxo-olean-12(13),17(18)-diene
0.03
-
in 50 mM citrate (pH 6.0), 1 mM dithiothreitol, 1 mM EDTA, and 0.1 M NaCl, at 37°C Homo sapiens (4aR,6aR,6bS,8aR,12aS,14aR,14bR)-8a-hydroxy-4,4,6a,6b,11,11,14b-heptamethyl-1,4a,5,6,6a,6b,7,8a,9,10,11,12,12a,14,14a,14b-hexadecahydropicene-3,8(2H,4H)-dione