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Literature summary for 3.1.3.48 extracted from

  • Seo, C.; Sohn, J.H.; Ahn, J.S.; Yim, J.H.; Lee, H.K.; Oh, H.
    Protein tyrosine phosphatase 1B inhibitory effects of depsidone and pseudodepsidone metabolites from the Antarctic lichen Stereocaulon alpinum (2009), Bioorg. Med. Chem. Lett., 19, 2801-2803.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1-(2,6-dihydroxy-4-methoxy-3-methylphenyl)ethanone isolated from a methanol extract of the Antarctic lichen Stereocaulon alpinum Homo sapiens
3-butyl-7-(2,4-dihydroxy-6-pentylphenoxy)-3,5-dimethoxy-2-benzofuran-1(3H)-one a pseudodepsidone-type compound, isolated from a methanol extract of the Antarctic lichen Stereocaulon alpinum Homo sapiens
3-hydroxy-4-(methoxycarbonyl)-2,5-dimethylphenyl 3-acetyl-2,4-dihydroxy-6-methylbenzoate isolated from a methanol extract of the Antarctic lichen Stereocaulon alpinum Homo sapiens
3-[(1-butyl-1,6-dimethoxy-3-oxo-1,3-dihydro-2-benzofuran-4-yl)oxy]-4,6-dihydroxy-2-pentylbenzoic acid a pseudodepsidone-type compound, isolated from a methanol extract of the Antarctic lichen Stereocaulon alpinum Homo sapiens
8-hydroxy-3-methoxy-11-oxo-1-pentanoyl-6-pentyl-11H-dibenzo[b,e][1,4]dioxepine-7-carboxylic acid isolated from a methanol extract of the Antarctic lichen Stereocaulon alpinum Homo sapiens
lobaric acid a depsidone-type compound, isolated from a methanol extract of the Antarctic lichen Stereocaulon alpinum Homo sapiens
methyl 2,4-dihydroxy-6-methylbenzoate isolated from a methanol extract of the Antarctic lichen Stereocaulon alpinum Homo sapiens
methyl 3,8-dimethoxy-11-oxo-1-pentanoyl-6-pentyl-11H-dibenzo[b,e][1,4]dioxepine-7-carboxylate isolated from a methanol extract of the Antarctic lichen Stereocaulon alpinum Homo sapiens
methyl 3-formyl-2,4-dihydroxy-6-methylbenzoate isolated from a methanol extract of the Antarctic lichen Stereocaulon alpinum Homo sapiens
methyl 8-hydroxy-3-methoxy-11-oxo-1-pentanoyl-6-pentyl-11H-dibenzo[b,e][1,4]dioxepine-7-carboxylate isolated from a methanol extract of the Antarctic lichen Stereocaulon alpinum Homo sapiens
ursolic acid
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Synonyms

Synonyms Comment Organism
protein tyrosine phosphatase 1B
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
additional information PTPB1 inhibition kinetics, overview Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00087
-
-
Homo sapiens 8-hydroxy-3-methoxy-11-oxo-1-pentanoyl-6-pentyl-11H-dibenzo[b,e][1,4]dioxepine-7-carboxylic acid
0.00248
-
-
Homo sapiens 3-[(1-butyl-1,6-dimethoxy-3-oxo-1,3-dihydro-2-benzofuran-4-yl)oxy]-4,6-dihydroxy-2-pentylbenzoic acid
0.00302
-
-
Homo sapiens methyl 8-hydroxy-3-methoxy-11-oxo-1-pentanoyl-6-pentyl-11H-dibenzo[b,e][1,4]dioxepine-7-carboxylate
0.00308
-
-
Homo sapiens ursolic acid
0.00686
-
-
Homo sapiens 3-butyl-7-(2,4-dihydroxy-6-pentylphenoxy)-3,5-dimethoxy-2-benzofuran-1(3H)-one
0.00742
-
-
Homo sapiens methyl 3,8-dimethoxy-11-oxo-1-pentanoyl-6-pentyl-11H-dibenzo[b,e][1,4]dioxepine-7-carboxylate
0.0635
-
-
Homo sapiens 3-hydroxy-4-(methoxycarbonyl)-2,5-dimethylphenyl 3-acetyl-2,4-dihydroxy-6-methylbenzoate
0.2
-
above Homo sapiens methyl 2,4-dihydroxy-6-methylbenzoate
0.2
-
above Homo sapiens methyl 3-formyl-2,4-dihydroxy-6-methylbenzoate
0.2
-
above Homo sapiens 1-(2,6-dihydroxy-4-methoxy-3-methylphenyl)ethanone