Activating Compound | Comment | Organism | Structure |
---|---|---|---|
NaCl | activity against phosphotyrosine, optimal at 0.1 M | Homo sapiens | |
Triton X-100 | 0.1%, 25-30% activation | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | truncation mutant expressing the catalytic domain, significantly higher vmax and lower Km-values | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
NaCl | inhibits activity with 4-nitrophenyl phosphate | Homo sapiens | |
Sodium vanadate | 1 mM, 60-80% inhibition | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
2.4 | - |
4-nitrophenyl phosphate | pH 5.0 | Homo sapiens | |
3.2 | - |
phosphotyrosine | pH 5.0 | Homo sapiens | |
8.5 | - |
phosphotyrosine | pH 7.0 | Homo sapiens | |
9.5 | - |
4-nitrophenyl phosphate | pH 7.0 | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
68000 | - |
gel filtration | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
recombinant enzyme | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bone marrow | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
32300 | - |
pH 5.0 | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-nitrophenyl phosphate + H2O | - |
Homo sapiens | 4-nitrophenol + phosphate | - |
? | |
phosphotyrosine + H2O | - |
Homo sapiens | tyrosine + phosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | 1 * 68000, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
PTP-MEG2 | - |
Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
4.5 | - |
substrate phosphotyrosine | Homo sapiens |
5 | - |
substrate 4-nitrophenyl phosphate | Homo sapiens |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
7 | - |
30-40% of the activity at optimal pH-value | Homo sapiens |