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Literature summary for 3.1.3.48 extracted from

  • Qi, Y.; Zhao, R.; Cao, H.; Sui, X.; Krantz, S.B.; Zhao, Z.J.
    Purification and characterization of protein tyrosine phosphatase PTP-MEG2 (2002), J. Cell. Biochem., 86, 79-89.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
NaCl activity against phosphotyrosine, optimal at 0.1 M Homo sapiens
Triton X-100 0.1%, 25-30% activation Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information truncation mutant expressing the catalytic domain, significantly higher vmax and lower Km-values Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
NaCl inhibits activity with 4-nitrophenyl phosphate Homo sapiens
Sodium vanadate 1 mM, 60-80% inhibition Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4
-
4-nitrophenyl phosphate pH 5.0 Homo sapiens
3.2
-
phosphotyrosine pH 5.0 Homo sapiens
8.5
-
phosphotyrosine pH 7.0 Homo sapiens
9.5
-
4-nitrophenyl phosphate pH 7.0 Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
68000
-
gel filtration Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
recombinant enzyme
-

Source Tissue

Source Tissue Comment Organism Textmining
bone marrow
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
32300
-
pH 5.0 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrophenyl phosphate + H2O
-
Homo sapiens 4-nitrophenol + phosphate
-
?
phosphotyrosine + H2O
-
Homo sapiens tyrosine + phosphate
-
?

Subunits

Subunits Comment Organism
monomer 1 * 68000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
PTP-MEG2
-
Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
4.5
-
substrate phosphotyrosine Homo sapiens
5
-
substrate 4-nitrophenyl phosphate Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
7
-
30-40% of the activity at optimal pH-value Homo sapiens