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Literature summary for 3.1.3.48 extracted from

  • Thompson, L.J.; Jiang, J.; Madamanchi, N.; Runge, M.S.; Patterson, C.
    PTP-epsilon, a tyrosine phosphatase expressed in endothelium, negatively regulates endothelial cell proliferation (2001), Am. J. Physiol., 281, H396-H403.
    View publication on PubMed

Application

Application Comment Organism
medicine role of enzyme in angiogenesis and signaling, overexpression of enzyme decreases proliferation by 60% in human umbilical vein endothelial cells but not in smooth muscle cells or fibroblasts Homo sapiens

Protein Variants

Protein Variants Comment Organism
D284A catalytically inactive, no significant effect on proliferation in human umbilical vein endothelial cells Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
recombinant protein expressed in various human cell lines
-