Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | low nanomolar Zn2+ concentrations inhibit isoform PTB1Bll | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0039 | - |
6,8-difluoro-4-methylumbelliferyl phosphate | at pH 7.4 and 25°C | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
[a protein]-tyrosine phosphate + H2O | Homo sapiens | - |
[a protein]-tyrosine + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P18031 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
6,8-difluoro-4-methylumbelliferyl phosphate + H2O | - |
Homo sapiens | 6,8-difluoro-4-methylumbelliferone + phosphate | - |
? | |
[a protein]-tyrosine phosphate + H2O | - |
Homo sapiens | [a protein]-tyrosine + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
protein tyrosine phosphatase 1B | - |
Homo sapiens |
protein tyrosine phosphatase, non-receptor type 1 | - |
Homo sapiens |
PTP1B | - |
Homo sapiens |
PTPN1 | - |
Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
8.66 | - |
6,8-difluoro-4-methylumbelliferyl phosphate | at pH 7.4 and 25°C | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000056 | - |
Zn2+ | at pH 7.4 and 25°C | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | isoform PTP1B (PTPN1) regulates the insulin and leptin signalling pathway and is implicated in cancer and obesity/diabetes | Homo sapiens |