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Literature summary for 3.1.3.48 extracted from

  • Bellomo, E.; Massarotti, A.; Hogstrand, C.; Maret, W.
    Zinc ions modulate protein tyrosine phosphatase 1B activity (2014), Metallomics, 6, 1229-1239.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Zn2+ low nanomolar Zn2+ concentrations inhibit isoform PTB1Bll Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0039
-
6,8-difluoro-4-methylumbelliferyl phosphate at pH 7.4 and 25°C Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[a protein]-tyrosine phosphate + H2O Homo sapiens
-
[a protein]-tyrosine + phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P18031
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6,8-difluoro-4-methylumbelliferyl phosphate + H2O
-
Homo sapiens 6,8-difluoro-4-methylumbelliferone + phosphate
-
?
[a protein]-tyrosine phosphate + H2O
-
Homo sapiens [a protein]-tyrosine + phosphate
-
?

Synonyms

Synonyms Comment Organism
protein tyrosine phosphatase 1B
-
Homo sapiens
protein tyrosine phosphatase, non-receptor type 1
-
Homo sapiens
PTP1B
-
Homo sapiens
PTPN1
-
Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
8.66
-
6,8-difluoro-4-methylumbelliferyl phosphate at pH 7.4 and 25°C Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000056
-
Zn2+ at pH 7.4 and 25°C Homo sapiens

General Information

General Information Comment Organism
physiological function isoform PTP1B (PTPN1) regulates the insulin and leptin signalling pathway and is implicated in cancer and obesity/diabetes Homo sapiens