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Literature summary for 3.1.3.48 extracted from

  • Korporaal, S.J.; Koekman, C.A.; Verhoef, S.; van der Wal, D.E.; Bezemer, M.; Van Eck, M.; Akkerman, J.W.
    Downregulation of platelet responsiveness upon contact with LDL by the protein-tyrosine phosphatases SHP-1 and SHP-2 (2009), Arterioscler. Thromb. Vasc. Biol., 29, 372-379.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens activation of SPH-1 and SPH-2 is accompanied by reduced responsiveness to aggregating agents, phosphorylation of SPH-1 and SPH-2 introduces docking sites for adaptor molecules like growth factor receptor-bound protein 2 regulating further signaling to integrin alphaIIbbeta3 ?
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood platelet
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Homo sapiens
-
hematopoietic cell
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Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information activation of SPH-1 and SPH-2 is accompanied by reduced responsiveness to aggregating agents, phosphorylation of SPH-1 and SPH-2 introduces docking sites for adaptor molecules like growth factor receptor-bound protein 2 regulating further signaling to integrin alphaIIbbeta3 Homo sapiens ?
-
?
phosphorylated p38 mitogen-activated protein kinase + H2O
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Homo sapiens p38 mitogen-activated protein kinase + phosphate
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?

Synonyms

Synonyms Comment Organism
SH2 domain-containing tyrosine phosphatase-1
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Homo sapiens
SH2 domain-containing tyrosine phosphatase-2
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Homo sapiens
SHP-1
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Homo sapiens
SHP-2
-
Homo sapiens