Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-carboperoxybenzoate | complete inhibition at 150 mM | Homo sapiens | |
2-hydroperoxytetrahydrofuran | inactivation by 2-hydroperoxytetrahydrofuran (0.05 mM, 10 min) is reversed upon reaction of the enzyme with dithiothreitol (54% return of activity, following treatment with 100 mM dthiothreitol for 1 h) | Homo sapiens | |
3-chlorobenzenecarboperoxoic acid | complete inhibition at 150 mM | Homo sapiens | |
additional information | tert-butyl hydroperoxide cumene hydroperoxide do not inactivate PTP1B, 150 nM H2O2 has no measurable effect on enzyme activity | Homo sapiens | |
peracetic acid | a potent, time-dependent inactivator of the catalytic subunit of PTP1B, treatment of the enzyme with 0.015 mM for 15 sec inactivates 88% of the enzyme, inactivation of PTP1B by peracetic acid can be reversed by treatment of the enzyme with thiols | Homo sapiens | |
PO43- | treatment of the enzyme with 0.05 mM PO43- for 15 sec inactivates 49% of the enzyme | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphotyrosine + H2O | - |
Homo sapiens | tyrosine + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
protein tyrosine phosphatase 1B | - |
Homo sapiens |
PTP1B | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.017 | - |
PO43- | active site-directed inhibitor | Homo sapiens |