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Literature summary for 3.1.3.48 extracted from

  • Bhattacharya, S.; Labutti, J.N.; Seiner, D.R.; Gates, K.S.
    Oxidative inactivation of protein tyrosine phosphatase 1B by organic hydroperoxides (2008), Bioorg. Med. Chem. Lett., 18, 5856-5859.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
2-carboperoxybenzoate complete inhibition at 150 mM Homo sapiens
2-hydroperoxytetrahydrofuran inactivation by 2-hydroperoxytetrahydrofuran (0.05 mM, 10 min) is reversed upon reaction of the enzyme with dithiothreitol (54% return of activity, following treatment with 100 mM dthiothreitol for 1 h) Homo sapiens
3-chlorobenzenecarboperoxoic acid complete inhibition at 150 mM Homo sapiens
additional information tert-butyl hydroperoxide cumene hydroperoxide do not inactivate PTP1B, 150 nM H2O2 has no measurable effect on enzyme activity Homo sapiens
peracetic acid a potent, time-dependent inactivator of the catalytic subunit of PTP1B, treatment of the enzyme with 0.015 mM for 15 sec inactivates 88% of the enzyme, inactivation of PTP1B by peracetic acid can be reversed by treatment of the enzyme with thiols Homo sapiens
PO43- treatment of the enzyme with 0.05 mM PO43- for 15 sec inactivates 49% of the enzyme Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphotyrosine + H2O
-
Homo sapiens tyrosine + phosphate
-
?

Synonyms

Synonyms Comment Organism
protein tyrosine phosphatase 1B
-
Homo sapiens
PTP1B
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.017
-
PO43- active site-directed inhibitor Homo sapiens