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Literature summary for 3.1.3.48 extracted from

  • Kiyan, J.; Haller, H.; Dumler, I.
    The tyrosine phosphatase SHP-2 controls urokinase-dependent signaling and functions in human vascular smooth muscle cells (2008), Exp. Cell Res., 315, 1029-1039.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
UpA uPA regulates SHP-2 phosphorylation, stimulates its catalytic activity and association with PDGFR-beta and with lipid rafts Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Homo sapiens 5829
-
nucleus SHP-2 can dephosphorylate STAT1 in cell nucleus Homo sapiens 5634
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
vascular smooth muscle cell
-
Homo sapiens
-
VSMC cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrophenyl phosphate + H2O
-
Homo sapiens 4-nitrophenol + phosphate
-
?
phosphorylated platelet-derived growth factor receptor + H2O
-
Homo sapiens platelet-derived growth factor receptor + phosphate
-
?
phosphorylated STAT1 + H2O
-
Homo sapiens STAT1 + phosphate
-
?

Synonyms

Synonyms Comment Organism
PTK
-
Homo sapiens
Scr homology 2-containing tyrosine phosphatase
-
Homo sapiens
SHP-2
-
Homo sapiens
tyrosine phosphatase
-
Homo sapiens