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Literature summary for 3.1.3.48 extracted from

  • Xu, D.; Qu, C.K.
    Protein tyrosine phosphatases in the JAK/STAT pathway (2008), Front. Biosci., 13, 4925-4932.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in in Ba/F3 cells and in primary bone marrow hematopoietic progenitor cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
C459S substrate-trapping mutant of SHP2 Homo sapiens
D61G the mutation causes hyperactivation of the SHP2 catalytic activity Homo sapiens
E76K the mutation causes hyperactivation of the SHP2 catalytic activity, dephosphorylation of STAT5 by SHP2 E76K is delayed Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hematopoietic cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphorylated JAK2 + H2O SHP2 dephosphorylates the Tyr1007 site, preventing the formation of the JAK2-Socs1 complex Homo sapiens JAK2 + phosphate
-
?
phosphorylated STAT1 + H2O purified GST-SHP2 dephosphorylates STAT1 at both tyrosine and serine residues when immunoprecipitated phosphorylated STAT1 or phosphor-peptides corresponding to the sequence surrounding Tyr701 or Ser727 of STAT1 are used as the substrates, SHP2 negatively regulates the interferon-induced JAK/STAT pathway by dephosphorylating STAT1 Homo sapiens STAT1 + phosphate
-
?
phosphorylated STAT3 + H2O SHP2 negatively regulates the activity of STAT3 Homo sapiens STAT3 + phosphate
-
?
phosphorylated STAT5 + H2O purified SHP2 protein directly dephosphorylates STAT5 or tyrosine-phosphorylated peptides derived from STAT5 Homo sapiens STAT5 + phosphate
-
?

Synonyms

Synonyms Comment Organism
protein tyrosine phosphatase
-
Homo sapiens
PTP
-
Homo sapiens
SHP2
-
Homo sapiens