Cloned (Comment) | Organism |
---|---|
expressed in in Ba/F3 cells and in primary bone marrow hematopoietic progenitor cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
C459S | substrate-trapping mutant of SHP2 | Homo sapiens |
D61G | the mutation causes hyperactivation of the SHP2 catalytic activity | Homo sapiens |
E76K | the mutation causes hyperactivation of the SHP2 catalytic activity, dephosphorylation of STAT5 by SHP2 E76K is delayed | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hematopoietic cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphorylated JAK2 + H2O | SHP2 dephosphorylates the Tyr1007 site, preventing the formation of the JAK2-Socs1 complex | Homo sapiens | JAK2 + phosphate | - |
? | |
phosphorylated STAT1 + H2O | purified GST-SHP2 dephosphorylates STAT1 at both tyrosine and serine residues when immunoprecipitated phosphorylated STAT1 or phosphor-peptides corresponding to the sequence surrounding Tyr701 or Ser727 of STAT1 are used as the substrates, SHP2 negatively regulates the interferon-induced JAK/STAT pathway by dephosphorylating STAT1 | Homo sapiens | STAT1 + phosphate | - |
? | |
phosphorylated STAT3 + H2O | SHP2 negatively regulates the activity of STAT3 | Homo sapiens | STAT3 + phosphate | - |
? | |
phosphorylated STAT5 + H2O | purified SHP2 protein directly dephosphorylates STAT5 or tyrosine-phosphorylated peptides derived from STAT5 | Homo sapiens | STAT5 + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
protein tyrosine phosphatase | - |
Homo sapiens |
PTP | - |
Homo sapiens |
SHP2 | - |
Homo sapiens |