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Literature summary for 3.1.3.48 extracted from

  • Zhao, Y.; Zhang, X.; Guda, K.; Lawrence, E.; Sun, Q.; Watanabe, T.; Iwakura, Y.; Asano, M.; Wei, L.; Yang, Z.; Zheng, W.; Dawson, D.; Willis, J.; Markowitz, S.D.; Satake, M.; Wang, Z.
    Identification and functional characterization of paxillin as a target of protein tyrosine phosphatase receptor T (2010), Proc. Natl. Acad. Sci. USA, 107, 2592-2597.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
drug development MptpB is a promising target for development of anti-tuberculosis drugs Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information development of a rapid high-throughput screening method for PTP inhibitors, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
paxilin tyrosine phosphate + H2O Homo sapiens PTPRT specifically regulates paxillin phosphorylation at Tyr88 in colorectal cancer cells paxilin tyrosine + phosphate
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
carcinoma cell
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Homo sapiens
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colorectal cancer cell
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Homo sapiens
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HEK-293T cell
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Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
paxilin tyrosine phosphate + H2O PTPRT specifically regulates paxillin phosphorylation at Tyr88 in colorectal cancer cells Homo sapiens paxilin tyrosine + phosphate
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paxilin tyrosine phosphate + H2O substrate of PTPRT, inactive with paxilin mutant Y88F Homo sapiens paxilin tyrosine + phosphate
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Synonyms

Synonyms Comment Organism
Protein tyrosine phosphatase receptor-type T
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Homo sapiens
PTPRT
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Homo sapiens

General Information

General Information Comment Organism
additional information CRC cells homozygous for a paxillin Y88F knock-in mutant exhibit significantly reduced cell migration and impaired anchorage-independent growth, and they fail to form xenograft tumors in nude mice, and have decreased phosphorylation of p130CAS, SHP2, and AKT Homo sapiens
physiological function PTPRT is involved in important signaling pathway that plays a critical role in colorectal tumorigenesis, overview Homo sapiens