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Literature summary for 3.1.3.48 extracted from

  • Puius, Y.A.; Zhao, Y.; Sullivan, M.; Lawrence, D.S.; Almo, S.C.; Zhang, Z.Y.
    Identification of a second aryl phosphate-binding site in protein-tyrosine phosphatase 1B: a paradigm for inhibitor design (1997), Proc. Natl. Acad. Sci. USA, 94, 13420-13425.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

Crystallization (Comment) Organism
active site mutant C215S in complex with substrates bis-(para-phosphophenyl) methane and 4-nitrophenyl phosphate Homo sapiens

Protein Variants

Protein Variants Comment Organism
C215S crystallization data, in complex with substrates bis-(para-phosphophenyl) methane and 4-nitrophenyl phosphate Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P18031 recombinant enzyme PTP1B
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Reaction

Reaction Comment Organism Reaction ID
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate in addition to active site, enzyme has a low-affinity noncatalytic aryl phosphate-binding site Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
brain fetal brain Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrophenyl phosphate + H2O
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Homo sapiens 4-nitrophenol + phosphate
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?
bis-(p-phosphophenyl) methane + H2O synthetic high-affinity low-molecular weight nonpeptide substrate Homo sapiens ?
-
?