Crystallization (Comment) | Organism |
---|---|
active site mutant C215S in complex with substrates bis-(para-phosphophenyl) methane and 4-nitrophenyl phosphate | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
C215S | crystallization data, in complex with substrates bis-(para-phosphophenyl) methane and 4-nitrophenyl phosphate | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P18031 | recombinant enzyme PTP1B | - |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate | in addition to active site, enzyme has a low-affinity noncatalytic aryl phosphate-binding site | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | fetal brain | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-nitrophenyl phosphate + H2O | - |
Homo sapiens | 4-nitrophenol + phosphate | - |
? | |
bis-(p-phosphophenyl) methane + H2O | synthetic high-affinity low-molecular weight nonpeptide substrate | Homo sapiens | ? | - |
? |