Inhibitors | Comment | Organism | Structure |
---|---|---|---|
CinnGel 2ME | the free cinnamic acid component of CinnGEL 2Me inhibits PTP1B | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | at least a subset of PTP1B is localized to the cytoplasm and most likely to the endoplasmic reticulum | Homo sapiens | 5737 | - |
endoplasmic reticulum | at least a subset of PTP1B is localized to the cytoplasm and most likely to the endoplasmic reticulum | Homo sapiens | 5783 | - |
nucleus | some punctate staining is observed in nuclei | Homo sapiens | 5634 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
37000 | - |
non-specific proteolytic cleavage of PTP1B yields a band migrating at approximately 37000 Da, SDS-PAGE | Homo sapiens |
46000 | - |
truncated form of PTP1B that is missing the COOH-terminal hydrophobic domain, SDS-PAGE | Homo sapiens |
48000 | - |
truncated form of PTP1B that is missing the COOH-terminal hydrophobic domain, SDS-PAGE | Homo sapiens |
50000 | - |
full-length PTP1B, SDS-PAGE | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cornea | - |
Homo sapiens | - |
corneal endothelial cell | - |
Homo sapiens | - |
corneal endothelial cell | localized in the endothelium of ex vivo corneas and in cultured cells | Homo sapiens | - |
SW-480 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphorylated epidermal growth factor receptor + H2O | PTP1B negatively regulates EGF-induced signaling in HCEC cells by dephosphorylating the epidermal growth factor receptor | Homo sapiens | epidermal growth factor receptor + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
protein tyrosine phosphatase-1B | - |
Homo sapiens |
PTP1B | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0013 | - |
- |
Homo sapiens | CinnGel 2ME |