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Literature summary for 3.1.3.48 extracted from

  • Ishino, Y.; Zhu, C.; Harris, D.L.; Joyce, N.C.
    Protein tyrosine phosphatase-1B (PTP1B) helps regulate EGF-induced stimulation of S-phase entry in human corneal endothelial cells (2008), Mol. Vis., 14, 61-70.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
CinnGel 2ME the free cinnamic acid component of CinnGEL 2Me inhibits PTP1B Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm at least a subset of PTP1B is localized to the cytoplasm and most likely to the endoplasmic reticulum Homo sapiens 5737
-
endoplasmic reticulum at least a subset of PTP1B is localized to the cytoplasm and most likely to the endoplasmic reticulum Homo sapiens 5783
-
nucleus some punctate staining is observed in nuclei Homo sapiens 5634
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
37000
-
non-specific proteolytic cleavage of PTP1B yields a band migrating at approximately 37000 Da, SDS-PAGE Homo sapiens
46000
-
truncated form of PTP1B that is missing the COOH-terminal hydrophobic domain, SDS-PAGE Homo sapiens
48000
-
truncated form of PTP1B that is missing the COOH-terminal hydrophobic domain, SDS-PAGE Homo sapiens
50000
-
full-length PTP1B, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cornea
-
Homo sapiens
-
corneal endothelial cell
-
Homo sapiens
-
corneal endothelial cell localized in the endothelium of ex vivo corneas and in cultured cells Homo sapiens
-
SW-480 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphorylated epidermal growth factor receptor + H2O PTP1B negatively regulates EGF-induced signaling in HCEC cells by dephosphorylating the epidermal growth factor receptor Homo sapiens epidermal growth factor receptor + phosphate
-
?

Synonyms

Synonyms Comment Organism
protein tyrosine phosphatase-1B
-
Homo sapiens
PTP1B
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0013
-
-
Homo sapiens CinnGel 2ME