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Literature summary for 3.1.3.48 extracted from

  • Price, K.A.; Caragounis, A.; Paterson, B.M.; Filiz, G.; Volitakis, I.; Masters, C.L.; Barnham, K.J.; Donnelly, P.S.; Crouch, P.J.; White, A.R.
    Sustained activation of glial cell epidermal growth factor receptor by bis(thiosemicarbazonato) metal complexes is associated with inhibition of protein tyrosine phosphatase activity (2009), J. Med. Chem., 52, 6606-6620.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
glyoxalbis(N(4)-methylthiosemicarbazonato)Cu(II) inhibition of protein tyrosine phosphatase activity is the prerequisite for activation of epidermal growth factor receptor by the compound, overview Homo sapiens
additional information bis(thiosemicarbazonato) metal complexes, e.g. with Cu2+ or Zn2+, inhibit PTP and its dephophorylating and inhibitory activity on the epidermal growth factor receptor, EGFR Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
phosphorylated epidermal growth factor receptor + H2O Homo sapiens inactivation of EGFR epidermal growth factor receptor + phosphate
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
astroglial cell
-
Homo sapiens
-
brain
-
Homo sapiens
-
glial cell
-
Homo sapiens
-
neuronal cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphorylated epidermal growth factor receptor + H2O
-
Homo sapiens epidermal growth factor receptor + phosphate
-
?
phosphorylated epidermal growth factor receptor + H2O inactivation of EGFR Homo sapiens epidermal growth factor receptor + phosphate
-
?

Synonyms

Synonyms Comment Organism
protein tyrosine phosphatase
-
Homo sapiens
PTP
-
Homo sapiens