Inhibitors | Comment | Organism | Structure |
---|---|---|---|
glyoxalbis(N(4)-methylthiosemicarbazonato)Cu(II) | inhibition of protein tyrosine phosphatase activity is the prerequisite for activation of epidermal growth factor receptor by the compound, overview | Homo sapiens | |
additional information | bis(thiosemicarbazonato) metal complexes, e.g. with Cu2+ or Zn2+, inhibit PTP and its dephophorylating and inhibitory activity on the epidermal growth factor receptor, EGFR | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphorylated epidermal growth factor receptor + H2O | Homo sapiens | inactivation of EGFR | epidermal growth factor receptor + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
astroglial cell | - |
Homo sapiens | - |
brain | - |
Homo sapiens | - |
glial cell | - |
Homo sapiens | - |
neuronal cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphorylated epidermal growth factor receptor + H2O | - |
Homo sapiens | epidermal growth factor receptor + phosphate | - |
? | |
phosphorylated epidermal growth factor receptor + H2O | inactivation of EGFR | Homo sapiens | epidermal growth factor receptor + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
protein tyrosine phosphatase | - |
Homo sapiens |
PTP | - |
Homo sapiens |