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Literature summary for 3.1.3.48 extracted from

  • Raugei, G.; Ramponi, G.; Chiarugi, P.
    Low molecular weight protein tyrosine phosphatases: small, but smart (2002), Cell. Mol. Life Sci., 59, 941-949.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information activation of enzyme after treatment with platelet derived growth factor, overview Mammalia

Inhibitors

Inhibitors Comment Organism Structure
H2O2 inactivation, phosphate protects, mechanism, overview Homo sapiens
NO inactivation, phosphate protects Homo sapiens
phosphate competitive Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoskeleton associated to Mammalia 5856
-
cytosol
-
Mammalia 5829
-
membrane associated to plasma membrane Mammalia 16020
-
additional information overview Mammalia
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
18000
-
x * 18000, all known members of enzyme subfamily, overview Mammalia

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mammalia possible specific substrate is p190Rho-GAP ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
two isozymes
-
Mammalia
-
low molecular weight enzyme subfamily, overview
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein regulation of enzyme activity by phosphorylation at T132, physiological effects, overview Mammalia

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
regulation of enzyme by redox mechanism, overview Mammalia
additional information
-
regulation of enzyme by redox mechanism, overview Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information possible specific substrate is p190Rho-GAP Mammalia ?
-
?

Subunits

Subunits Comment Organism
? x * 18000, all known members of enzyme subfamily, overview Mammalia
More three-dimensional structure model Mammalia

Synonyms

Synonyms Comment Organism
LMW-PTP
-
Mammalia