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Literature summary for 3.1.3.48 extracted from

  • Cui, L.; Yu, W.P.; DeAizpurua, H.J.; Schmidli, R.S.; Pallen, C.J.
    Cloning and characterization of islet cell antigen-related protein-tyrosine phosphatase (PTP), a novel receptor-like PTP and autoantigen in insulin-dependent diabetis (1996), J. Biol. Chem., 271, 24817-24823.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
-
Homo sapiens

Protein Variants

Protein Variants Comment Organism
C945S site-directed mutagenesis of the essential cysteine residue to a serine in the islet cell antigen-related PTP results in the expression of the intracellular region which does not catalyze hydrolysis of 4-nitrophenyl phosphate Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
H3VO4
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrophenyl phosphate + H2O
-
Homo sapiens 4-nitrophenol + phosphate
-
?
phosphotyrosyl-casein + H2O
-
Homo sapiens ? + phosphate
-
?

Synonyms

Synonyms Comment Organism
IAR
-
Homo sapiens
islet cell antigen-related PTP
-
Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
4.5
-
islet cell antigen-related PTP Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
4 4.5 islet cell antigen-related PTP Homo sapiens