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Literature summary for 3.1.3.48 extracted from

  • Moretto, A.F.; Kirincich, S.J.; Xu, W.X.; Smith, M.J.; Wan, Z.K.; Wilson, D.P.; Follows, B.C.; Binnun, E.; Joseph-McCarthy, D.; Foreman, K.; Erbe, D.V.; Zhang, Y.L.; Tam, S.K.; Tam, S.Y.; Lee, J.
    Bicyclic and tricyclic thiophenes as protein tyrosine phosphatase 1B inhibitors (2006), Bioorg. Med. Chem., 14, 2162-2177.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
3-(1-carboxy-ethoxy)-6-chloro-benzo(b)-thiophene-2-carboxylic acid
-
Homo sapiens
3-(carboxy-fluoro-methoxy)-6-chloro-benzo(b)thiophene-2-carboxylic acid
-
Homo sapiens
3-(carboxymethoxy)-2-naphthoic acid
-
Homo sapiens
3-(carboxymethoxy)-5-((cyclohexylmethyl)-amino)thieno(3,2-b)(1)benzothiophene-2-carboxylic acid
-
Homo sapiens
3-(carboxymethoxy)-5-(cyclohexylamino)-thieno(3,2-b)(1)benzothiophene-2-carboxylic acid
-
Homo sapiens
3-(carboxymethoxy)-5-chlorothieno(3,2-b)(1)benzothiophene-2-carboxylic acid
-
Homo sapiens
3-(carboxymethoxy)-6-((1-(ethylsulfonyl)-piperidin-4-yl)amino)thieno(3,2-b)(1)benzothiophene-2-carboxylic acid
-
Homo sapiens
3-(carboxymethoxy)-6-((cyclohexylmethyl)-amino)thieno(3,2-b)(1)benzothiophene-2-carboxylic acid
-
Homo sapiens
3-(carboxymethoxy)-6-(cyclohexylamino)-thieno(3,2-b)(1)benzothiophene-2-carboxylic acid
-
Homo sapiens
3-(carboxymethoxy)-6-(tetrahydro-2H-pyran-4-ylamino)thieno(3,2-b)(1)benzothiophene-2-carboxylic acid
-
Homo sapiens
3-(carboxymethoxy)-6-chlorothieno(3,2-b)(1)benzothiophene-2-carboxylic acid
-
Homo sapiens
3-(carboxymethoxy)-6-methylthieno(3,2-c)pyridine-2-carboxylic acid
-
Homo sapiens
3-(carboxymethoxy)benzo(b)thiophene-2-carboxylic acid
-
Homo sapiens
3-(carboxymethoxy)furo(2,3-b)pyridine-2-carboxylic acid
-
Homo sapiens
3-(carboxymethoxy)thieno(2,3-b)pyridine-2-carboxylic acid reversible, competitive Homo sapiens
3-(carboxymethoxy)thieno(3,2-b)(1)benzo-thiophene-2-carboxylic acid
-
Homo sapiens
3-(carboxymethoxy)thieno(3,2-b)pyridine-2-carboxylic acid
-
Homo sapiens
3-(carboxymethoxy)thieno(3,2-b)thiophene-2-carboxylic acid
-
Homo sapiens
3-carboxymethoxy-6-(4-hydroxyphenyl)-benzo(b)-thiophene-2-carboxylic acid
-
Homo sapiens
3-carboxymethoxy-6-(5-methyl-1-phenyl-1H-pyrazol-3-ylcarbamoyl)-benzo(b)thiophene-2-carboxylic acid
-
Homo sapiens
3-carboxymethoxy-6-chloro-benzo(b)-thiophene-2-carboxylic acid
-
Homo sapiens
3-carboxymethoxy-6-phenylbenzo(b)-thiophene-2-carboxylic acid
-
Homo sapiens
3-carboxymethoxy-6-thiophen-2-yl-benzo(b)-thiophene-2-carboxylic acid
-
Homo sapiens
3-carboxymethoxy-7-chloro-benzo(b)-thiophene-2-carboxylic acid
-
Homo sapiens
3-carboxymethoxy-7-methyl-benzo(b)-thiophene-2-carboxylic acid
-
Homo sapiens
3-carboxymethoxy-naphtho(1,2-b)thiophene-2-carboxylic acid
-
Homo sapiens
3-carboxymethoxy-thieno(3,2-c)quinoline-2-carboxylic acid
-
Homo sapiens
6-((1-(benzylsulfonyl)piperidin-4-yl)amino)-3-(carboxymethoxy)thieno(3,2-b)(1)benzothiophene-2-carboxylic acid
-
Homo sapiens
6-bromo-3-carboxymethoxy-benzo(b)-thiophene-2-carboxylic acid
-
Homo sapiens
acid
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
isoform PTP1B
-

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00037
-
6-((1-(benzylsulfonyl)piperidin-4-yl)amino)-3-(carboxymethoxy)thieno(3,2-b)(1)benzothiophene-2-carboxylic acid pH 7.0, 22°C Homo sapiens
0.00068
-
3-(carboxymethoxy)-6-((cyclohexylmethyl)-amino)thieno(3,2-b)(1)benzothiophene-2-carboxylic acid pH 7.0, 22°C Homo sapiens
0.00074
-
3-(carboxymethoxy)-6-(cyclohexylamino)-thieno(3,2-b)(1)benzothiophene-2-carboxylic acid pH 7.0, 22°C Homo sapiens
0.00092
-
3-(carboxymethoxy)-5-((cyclohexylmethyl)-amino)thieno(3,2-b)(1)benzothiophene-2-carboxylic acid pH 7.0, 22°C Homo sapiens
0.0016
-
3-(carboxymethoxy)-6-((1-(ethylsulfonyl)-piperidin-4-yl)amino)thieno(3,2-b)(1)benzo-thiophene-2-carboxylic acid pH 7.0, 22°C Homo sapiens
0.0017
-
3-(carboxymethoxy)-5-(cyclohexylamino)-thieno(3,2-b)(1)benzothiophene-2-carboxylic acid pH 7.0, 22°C Homo sapiens
0.0024
-
3-(carboxymethoxy)-6-(tetrahydro-2H-pyran-4-ylamino)thieno(3,2-b)(1)benzothiophene-2-carboxylic acid pH 7.0, 22°C Homo sapiens
0.0092
-
3-(carboxymethoxy)thieno(3,2-b)(1)benzo-thiophene-2-carboxylic acid pH 7.0, 22°C Homo sapiens
0.01
-
3-(carboxymethoxy)-5-chlorothieno(3,2-b)(1)benzothiophene-2-carboxylic acid pH 7.0, 22°C Homo sapiens
0.011
-
3-carboxymethoxy-naphtho(1,2-b)thiophene-2-carboxylic acid pH 7.0, 22°C Homo sapiens
0.02
-
3-carboxymethoxy-6-(5-methyl-1-phenyl-1H-pyrazol-3-ylcarbamoyl)-benzo(b)thiophene-2-carboxylic acid pH 7.0, 22°C Homo sapiens
0.026
-
3-carboxymethoxy-6-(4-hydroxyphenyl)-benzo(b)-thiophene-2-carboxylic acid pH 7.0, 22°C Homo sapiens
0.03
-
3-carboxymethoxy-6-thiophen-2-yl-benzo(b)-thiophene-2-carboxylic acid pH 7.0, 22°C Homo sapiens
0.035
-
3-(carboxymethoxy)-6-chlorothieno(3,2-b)(1)benzothiophene-2-carboxylic acid pH 7.0, 22°C Homo sapiens
0.037
-
3-carboxymethoxy-7-methyl-benzo(b)-thiophene-2-carboxylic acid pH 7.0, 22°C Homo sapiens
0.042
-
6-bromo-3-carboxymethoxy-benzo(b)-thiophene-2-carboxylic acid pH 7.0, 22°C Homo sapiens
0.052
-
3-(carboxy-fluoro-methoxy)-6-chloro-benzo(b)thiophene-2-carboxylic acid pH 7.0, 22°C Homo sapiens
0.061
-
3-carboxymethoxy-6-chloro-benzo(b)-thiophene-2-carboxylic acid pH 7.0, 22°C Homo sapiens
0.077
-
3-(carboxymethoxy)thieno(3,2-b)pyridine-2-carboxylic acid pH 7.0, 22°C Homo sapiens
0.119
-
3-carboxymethoxy-7-chloro-benzo(b)-thiophene-2-carboxylic acid pH 7.0, 22°C Homo sapiens
0.128
-
3-carboxymethoxy-6-phenylbenzo(b)-thiophene-2-carboxylic acid pH 7.0, 22°C Homo sapiens
0.16
-
3-(carboxymethoxy)benzo(b)thiophene-2-carboxylic acid pH 7.0, 22°C Homo sapiens
0.2
-
3-(carboxymethoxy)thieno(2,3-b)pyridine-2-carboxylic acid pH 5.5, 22°C Homo sapiens
0.23
-
3-(carboxymethoxy)thieno(2,3-b)pyridine-2-carboxylic acid pH 7.4, 22°C Homo sapiens
0.28
-
3-(carboxymethoxy)thieno(3,2-b)thiophene-2-carboxylic acid pH 7.0, 22°C Homo sapiens
0.5
-
3-carboxymethoxy-thieno(3,2-c)quinoline-2-carboxylic acid pH 7.0, 22°C Homo sapiens
0.86
-
3-(carboxymethoxy)-2-naphthoic acid pH 7.0, 22°C Homo sapiens
2.5
-
3-(carboxymethoxy)furo(2,3-b)pyridine-2-carboxylic acid pH 7.0, 22°C Homo sapiens
2.5
-
3-(carboxymethoxy)-6-methylthieno(3,2-c)pyridine-2-carboxylic acid pH 7.0, 22°C Homo sapiens
2.5
-
3-(1-carboxy-ethoxy)-6-chloro-benzo(b)-thiophene-2-carboxylic acid pH 7.0, 22°C Homo sapiens