Inhibitors | Comment | Organism | Structure |
---|---|---|---|
CinnGel 2ME | 30.2% inhibition at 0.02 mM | Homo sapiens | |
Phenylarsine oxide | 55.8% inhibition at 0.01 mM | Homo sapiens | |
potassium bisperoxo(1,10-phenanthroline)oxovanadate | complete inhibition at 0.01 mM | Homo sapiens | |
potassium bisperoxo(1,10-phenanthroline)oxovanadate | potent PTP inhibitor | Oryctolagus cuniculus | |
sodium orthovanadate | 17.5% inhibition at 1 mM | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | SHP-2 | Homo sapiens | 5829 | - |
cytosol | SHP-2, PTEN, and MSP | Oryctolagus cuniculus | 5829 | - |
endoplasmic reticulum | PTP1B | Oryctolagus cuniculus | 5783 | - |
membrane | PTP1B | Homo sapiens | 16020 | - |
membrane | PTP1B and LAR | Oryctolagus cuniculus | 16020 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Oryctolagus cuniculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cornea | - |
Oryctolagus cuniculus | - |
corneal epithelial cell | - |
Homo sapiens | - |
corneal epithelium | - |
Oryctolagus cuniculus | - |
HCE cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
DADEpYIPQQG + H2O | specific substrate for PTP1B | Homo sapiens | DADEYIPQQG + phosphate | - |
? | |
DADEpYIPQQG + H2O | specific substrate for PTP1B | Oryctolagus cuniculus | DADEYIPQQG + phosphate | - |
? | |
phosphorylated c-MET + H2O | PTP1B and SHP-2 are bound to the c-Met receptor to control its activity, PTP1B acts as a negative regulator, increased binding and phosphorylation of SHP-2 coincide with maximal stimulation of c-Met, therefore acting as a positive regulator | Homo sapiens | c-MET + phosphate | - |
? | |
phosphorylated c-MET + H2O | PTP1B and SHP-2 are bound to the c-Met receptor to control its activity, PTP1B acts as a negative regulator, increased binding and phosphorylation of SHP-2 coincide with maximal stimulation of c-Met, therefore acting as a positive regulator | Oryctolagus cuniculus | c-MET + phosphate | - |
? | |
phosphorylated p85 | - |
Oryctolagus cuniculus | p85 + phosphate | - |
? | |
phosphorylated protein p85 | - |
Homo sapiens | protein p85 + phosphate | - |
? | |
RRLIEDAEpYAARG + H2O | - |
Homo sapiens | RRLIEDAEYAARG + phosphate | - |
? | |
RRLIEDAEpYAARG + H2O | - |
Oryctolagus cuniculus | RRLIEDAEYAARG + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
LAR | - |
Oryctolagus cuniculus |
MSP | - |
Oryctolagus cuniculus |
protein tyrosine phosphatase-1B | - |
Homo sapiens |
protein tyrosine phosphatase-1B | - |
Oryctolagus cuniculus |
PTEN | - |
Oryctolagus cuniculus |
PTP1B | - |
Homo sapiens |
PTP1B | - |
Oryctolagus cuniculus |
SHP-1 | also known as PTP1C and SH-PTP1 | Homo sapiens |
SHP-1 | also known as PTP1C and SH-PTP1 | Oryctolagus cuniculus |
SHP-2 | also known as PTP1D and SH-PTP2 | Homo sapiens |
SHP-2 | also known as PTP1D and SH-PTP2 | Oryctolagus cuniculus |