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Literature summary for 3.1.3.48 extracted from

  • Kakazu, A.; Sharma, G.; Bazan, H.E.
    Association of protein tyrosine phosphatases (PTPs)-1B with c-Met receptor and modulation of corneal epithelial wound healing (2008), Invest. Ophthalmol. Vis. Sci., 49, 2927-2935.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
CinnGel 2ME 30.2% inhibition at 0.02 mM Homo sapiens
Phenylarsine oxide 55.8% inhibition at 0.01 mM Homo sapiens
potassium bisperoxo(1,10-phenanthroline)oxovanadate complete inhibition at 0.01 mM Homo sapiens
potassium bisperoxo(1,10-phenanthroline)oxovanadate potent PTP inhibitor Oryctolagus cuniculus
sodium orthovanadate 17.5% inhibition at 1 mM Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol SHP-2 Homo sapiens 5829
-
cytosol SHP-2, PTEN, and MSP Oryctolagus cuniculus 5829
-
endoplasmic reticulum PTP1B Oryctolagus cuniculus 5783
-
membrane PTP1B Homo sapiens 16020
-
membrane PTP1B and LAR Oryctolagus cuniculus 16020
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Oryctolagus cuniculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cornea
-
Oryctolagus cuniculus
-
corneal epithelial cell
-
Homo sapiens
-
corneal epithelium
-
Oryctolagus cuniculus
-
HCE cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DADEpYIPQQG + H2O specific substrate for PTP1B Homo sapiens DADEYIPQQG + phosphate
-
?
DADEpYIPQQG + H2O specific substrate for PTP1B Oryctolagus cuniculus DADEYIPQQG + phosphate
-
?
phosphorylated c-MET + H2O PTP1B and SHP-2 are bound to the c-Met receptor to control its activity, PTP1B acts as a negative regulator, increased binding and phosphorylation of SHP-2 coincide with maximal stimulation of c-Met, therefore acting as a positive regulator Homo sapiens c-MET + phosphate
-
?
phosphorylated c-MET + H2O PTP1B and SHP-2 are bound to the c-Met receptor to control its activity, PTP1B acts as a negative regulator, increased binding and phosphorylation of SHP-2 coincide with maximal stimulation of c-Met, therefore acting as a positive regulator Oryctolagus cuniculus c-MET + phosphate
-
?
phosphorylated p85
-
Oryctolagus cuniculus p85 + phosphate
-
?
phosphorylated protein p85
-
Homo sapiens protein p85 + phosphate
-
?
RRLIEDAEpYAARG + H2O
-
Homo sapiens RRLIEDAEYAARG + phosphate
-
?
RRLIEDAEpYAARG + H2O
-
Oryctolagus cuniculus RRLIEDAEYAARG + phosphate
-
?

Synonyms

Synonyms Comment Organism
LAR
-
Oryctolagus cuniculus
MSP
-
Oryctolagus cuniculus
protein tyrosine phosphatase-1B
-
Homo sapiens
protein tyrosine phosphatase-1B
-
Oryctolagus cuniculus
PTEN
-
Oryctolagus cuniculus
PTP1B
-
Homo sapiens
PTP1B
-
Oryctolagus cuniculus
SHP-1 also known as PTP1C and SH-PTP1 Homo sapiens
SHP-1 also known as PTP1C and SH-PTP1 Oryctolagus cuniculus
SHP-2 also known as PTP1D and SH-PTP2 Homo sapiens
SHP-2 also known as PTP1D and SH-PTP2 Oryctolagus cuniculus