Activating Compound | Comment | Organism | Structure |
---|---|---|---|
spermine | no effect at 0.02-0.2 mM | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
- |
Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | - |
Homo sapiens | |
H3VO4 | - |
Homo sapiens | |
heparin | - |
Homo sapiens | |
Mg2+ | - |
Homo sapiens | |
Mn2+ | - |
Homo sapiens | |
molybdate | - |
Homo sapiens | |
poly(Glu-Tyr) | - |
Homo sapiens | |
spermine | 2.0-20 mM | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.142 | - |
TSTEPQpYQPGENL | - |
Homo sapiens | |
0.175 | - |
GESDGGpYMDMSKD | - |
Homo sapiens | |
0.33 | - |
TGFLTELpYVATRWY | - |
Homo sapiens | |
2.5 | - |
4-nitrophenyl phosphate | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
plasma membrane | - |
Homo sapiens | 5886 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | PTPases regulate the ligand-induced autophosphorylation of PTK growth factor receptors, the phosphotyrosine-mediated binding s of src homology 2 (SH2)-domain-containing proteins to autophosphorylated PTK growth factor receptors and the activation state of the src family pf PTK | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Storage Stability | Organism |
---|---|
-80°C, 20% v/v glycerol, stable for more than 4 months | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-nitrophenyl phosphate + H2O | - |
Homo sapiens | 4-nitrophenol + phosphate | - |
? | |
GESDGGpYMDMSKD + H2O | this peptide corresponds to the sequence containing Tyr740 of the human platelet-derived growth factor receptor | Homo sapiens | GESDGGYMDMSKD + phosphate | - |
? | |
additional information | PTPases regulate the ligand-induced autophosphorylation of PTK growth factor receptors, the phosphotyrosine-mediated binding s of src homology 2 (SH2)-domain-containing proteins to autophosphorylated PTK growth factor receptors and the activation state of the src family pf PTK | Homo sapiens | ? | - |
? | |
TGFLTELpYVATRWY + H2O | this peptide corresponds to the sequence containing Tyr204 of the human extracellular signal-regulated kinase | Homo sapiens | TGFLTELYVATRWY + phosphate | - |
? | |
TSTEPQpYQPGENL + H2O | this sequence contains the C-terminal phosphorylation site of c-src with phosphorylated Tyr527 | Homo sapiens | TSTEPQYQPGENL + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HPTPbeta | - |
Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
177 | - |
TGFLTELpYVATRWY | - |
Homo sapiens | |
200 | - |
GESDGGpYMDMSKD | - |
Homo sapiens | |
258 | - |
TSTEPQpYQPGENL | - |
Homo sapiens |