Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.3.48 extracted from

  • Harder, K.W.; Owen, P.; Wong, L.K.H.; Aebersold, R.; Clark-Lewis, I.; Jirik, F.R.
    Characterization and kinetic analysis of the intracellular domain of human protein tyrosine phosphatase beta (HPTPbeta) using synthetic phosphopeptides (1994), Biochem. J., 298, 395-401.
No PubMed abstract available

Activating Compound

Activating Compound Comment Organism Structure
spermine no effect at 0.02-0.2 mM Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
-
Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Ca2+
-
Homo sapiens
H3VO4
-
Homo sapiens
heparin
-
Homo sapiens
Mg2+
-
Homo sapiens
Mn2+
-
Homo sapiens
molybdate
-
Homo sapiens
poly(Glu-Tyr)
-
Homo sapiens
spermine 2.0-20 mM Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.142
-
TSTEPQpYQPGENL
-
Homo sapiens
0.175
-
GESDGGpYMDMSKD
-
Homo sapiens
0.33
-
TGFLTELpYVATRWY
-
Homo sapiens
2.5
-
4-nitrophenyl phosphate
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane
-
Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens PTPases regulate the ligand-induced autophosphorylation of PTK growth factor receptors, the phosphotyrosine-mediated binding s of src homology 2 (SH2)-domain-containing proteins to autophosphorylated PTK growth factor receptors and the activation state of the src family pf PTK ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Storage Stability

Storage Stability Organism
-80°C, 20% v/v glycerol, stable for more than 4 months Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrophenyl phosphate + H2O
-
Homo sapiens 4-nitrophenol + phosphate
-
?
GESDGGpYMDMSKD + H2O this peptide corresponds to the sequence containing Tyr740 of the human platelet-derived growth factor receptor Homo sapiens GESDGGYMDMSKD + phosphate
-
?
additional information PTPases regulate the ligand-induced autophosphorylation of PTK growth factor receptors, the phosphotyrosine-mediated binding s of src homology 2 (SH2)-domain-containing proteins to autophosphorylated PTK growth factor receptors and the activation state of the src family pf PTK Homo sapiens ?
-
?
TGFLTELpYVATRWY + H2O this peptide corresponds to the sequence containing Tyr204 of the human extracellular signal-regulated kinase Homo sapiens TGFLTELYVATRWY + phosphate
-
?
TSTEPQpYQPGENL + H2O this sequence contains the C-terminal phosphorylation site of c-src with phosphorylated Tyr527 Homo sapiens TSTEPQYQPGENL + phosphate
-
?

Synonyms

Synonyms Comment Organism
HPTPbeta
-
Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
177
-
TGFLTELpYVATRWY
-
Homo sapiens
200
-
GESDGGpYMDMSKD
-
Homo sapiens
258
-
TSTEPQpYQPGENL
-
Homo sapiens