Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(Z)-1-(3-(3-carboxy-3-hydroxyacryloyl)benzyl)-6-iodo-4-oxo-1,4-dihydroquinoline-3-carboxylic acid | IC50 of 2.4 mg/ml | Homo sapiens | |
(Z)-1-(3-(4-ethoxy-3-hydroxy-4-oxobut-2-enoyl)benzyl)-6-iodo-4-oxo-1,4-dihydroquinoline-3-carboxylic acid | IC50 of 3.1 mg/ml | Homo sapiens | |
1,1'-(piperazine-1,4-diyl)bis(4-(3-(dibenzylamino)phenyl)butane-1,2,4-trione) | - |
Homo sapiens | |
1,6-dibenzyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid | 15.1% inhibition at 0.02 mg/ml | Homo sapiens | |
1-(4-fluorobenzyl)-6-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid | 36.2% inhibition at 0.02 mg/ml | Homo sapiens | |
1-(4-hydroxy-3-(methoxycarbonyl)benzyl)-6-iodo-4-oxo-1,4-dihydroquinoline-3-carboxylic acid | IC50 of 8.1 mg/ml | Homo sapiens | |
1-benzyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid | 15.1% inhibition at 0.02 mg/ml | Homo sapiens | |
1-benzyl-6-iodo-4-oxo-1,4-dihydroquinoline-3-carboxylic acid | 3.1% inhibition at 0.02 mg/ml | Homo sapiens | |
1-benzyl-7-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid | 0.7% inhibition at 0.02 mg/ml | Homo sapiens | |
1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid | 0.8% inhibition at 0.02 mg/ml | Homo sapiens | |
1-cyclopropyl-6-iodo-4-oxo-1,4-dihydroquinoline-3-carboxylic acid | 3.5% inhibition at 0.02 mg/ml | Homo sapiens | |
1-cyclopropyl-N-(4-fluorobenzyl)-6-iodo-4-oxo-1,4-dihydroquinoline-3-carboxamide | 3.3% inhibition at 0.02 mg/ml | Homo sapiens | |
4-(3-(dibenzylamino)phenyl)-2,4-dioxobutanoic acid | - |
Homo sapiens | |
4-fluorobenzyl-1-cyclopropyl-6-(4-fluorobenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylate | 73% inhibition at 0.02 mg/ml | Homo sapiens | |
6-(4-(3-(3-(benzyloxy)-2-(methoxycarbonyl)phenoxy)propyl)piperazin-1-yl)-1-cyclopropyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid | IC50 of 45.2 mg/ml | Homo sapiens | |
6-(4-benzylpiperazin-1-yl)-1-cyclopropyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid | 62.3% inhibition at 0.02 mg/ml | Homo sapiens | |
6-amino-1-(4-fluorobenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid | 12.4% inhibition at 0.02 mg/ml | Homo sapiens | |
6-benzyl-1-cyclopropyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid | 87.5% inhibition at 0.02 mg/ml | Homo sapiens | |
6-iodo-1-(4-methoxy-3-(methoxycarbonyl)benzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid | IC50 of more than 20 mg/ml | Homo sapiens | |
benzyl 1,6-dibenzyl-4-oxo-1,4-dihydroquinoline-3-carboxylate | 0.1% inhibition at 0.02 mg/ml | Homo sapiens | |
benzyl 1-cyclopropyl-6-iodo-4-oxo-1,4-dihydroquinoline-3-carboxylate | 80.5% inhibition at 0.02 mg/ml | Homo sapiens | |
cyclopropyl-6-(4-fluorobenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid | 71.1% inhibition at 0.02 mg/ml | Homo sapiens | |
methyl 2-(3-(1-(4-fluorobenzyl)-6-nitro-4-oxo-1,4-dihydroquinoline-3-carboxamido)propoxy)-6-hydroxybenzoate | IC50 of 6.5 mg/ml | Homo sapiens | |
methyl 2-(3-(1-benzyl-7-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxamido)propoxy)-6-hydroxybenzoate | IC50 of 9.4 mg/ml | Homo sapiens | |
methyl-5-((3-(benzylcarbamoyl)-6-iodo-4-oxoquinolin-1(4H)-yl)methyl)-2-methoxybenzoate | IC50 of more than 20 mg/ml | Homo sapiens | |
N,1-dibenzyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxamide | 41.4% inhibition at 0.02 mg/ml | Homo sapiens | |
N,1-dibenzyl-6-iodo-4-oxo-1,4-dihydroquinoline-3-carboxamide | 61.8% inhibition at 0.02 mg/ml | Homo sapiens | |
N-benzyl-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxamide | 0.2% inhibition at 0.02 mg/ml; 7.4% inhibition at 0.02 mg/ml | Homo sapiens | |
N-benzyl-1-cyclopropyl-6-iodo-4-oxo-1,4-dihydroquinoline-3-carboxamide | 6.1% inhibition at 0.02 mg/ml | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
[a protein]-tyrosine phosphate + H2O | Homo sapiens | - |
[a protein]-tyrosine + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-nitrophenyl phosphate + H2O | - |
Homo sapiens | 4-nitrophenol + phosphate | - |
? | |
[a protein]-tyrosine phosphate + H2O | - |
Homo sapiens | [a protein]-tyrosine + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
protein tyrosine phosphatase 1B | - |
Homo sapiens |
PTP1B | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0028 | - |
in 50 mM MOPS, pH 6.5, at 30°C | Homo sapiens | 1,1'-(piperazine-1,4-diyl)bis(4-(3-(dibenzylamino)phenyl)butane-1,2,4-trione) | |
0.02 | - |
in 50 mM MOPS, pH 6.5, at 30°C | Homo sapiens | 4-(3-(dibenzylamino)phenyl)-2,4-dioxobutanoic acid |