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Literature summary for 3.1.3.48 extracted from

  • Choi, J.Y.; Na, M.; Hyun Hwang, I.; Ho Lee, S.; Young Bae, E.; Yeon Kim, B.; Seog Ahn, J.
    Isolation of betulinic acid, its methyl ester and guaiane sesquiterpenoids with protein tyrosine phosphatase 1B inhibitory activity from the roots of Saussurea lappa C.B.Clarke (2009), Molecules, 14, 266-272.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
betulinic acid 95.1% PTP1B inhibitory activity with 0.0007 mg/ml Homo sapiens
betulinic acid methyl ester 89.4% PTP1B inhibitory activity with 0.00093 mg/ml Homo sapiens
dehydrocostuslactone 86.2% PTP1B inhibitory activity with 0.00651 mg/ml Homo sapiens
mokko lactone 93.1% PTP1B inhibitory activity with 0.00141 mg/ml Homo sapiens
additional information not inhibited by costunolide, 11beta,13-dihydrocostunolide, reynosin, 1beta-hydroxy arbusculin A, santamarine, alpha-costol, beta-sitosterol, aplotaxene, and alpha-amyrin stearate Homo sapiens
RK-682 98.5% PTP1B inhibitory activity with 0.0012 mg/ml Homo sapiens
ursolic acid 99% PTP1B inhibitory activity with 0.0007 mg/ml Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrophenyl phosphate + H2O
-
Homo sapiens 4-nitrophenol + phosphate
-
?

Synonyms

Synonyms Comment Organism
protein tyrosine phosphatase 1B
-
Homo sapiens
PTP1B
-
Homo sapiens
PTPase
-
Homo sapiens