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Literature summary for 3.1.3.48 extracted from

  • Lin, S.Y.; Raval, S.; Zhang, Z.; Deverill, M.; Siminovitch, K.A.; Branch, D.R.; Haimovich, B.
    The protein-tyrosine phosphatase SHP-1 regulates the phosphorylation of alpha-actinin (2004), J. Biol. Chem., 279, 25755-25764.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
additional information enzyme is active in unstimulated or thrombin-stimulated platelets. Enzyme is not active in lysate of platelets adherent to fibrinogen Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
68000
-
x * 68000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens SHP-1 may regulate the tethering of receptors to the cytoskeleton and/or the extent of cross-linking of actin filaments in platelets ?
-
?
phosphorylated alpha-actinin + H2O Homo sapiens
-
alpha-actinin + phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
blood platelet platelet lysate Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information SHP-1 may regulate the tethering of receptors to the cytoskeleton and/or the extent of cross-linking of actin filaments in platelets Homo sapiens ?
-
?
phosphorylated alpha-actinin + H2O
-
Homo sapiens alpha-actinin + phosphate
-
?

Subunits

Subunits Comment Organism
? x * 68000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
SHP-1
-
Homo sapiens