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Literature summary for 3.1.3.48 extracted from

  • Zhao, Z.; Laroque, R.; Ho, W.T.; Fischer, E.H.; Shen, S.H.
    Purification and characterization of PTP2C, a widely distributed protein tyrosine phosphatase containing two SH2 domains (1994), J. Biol. Chem., 269, 8780-8785.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
spermidine activation Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression of PTP2C and DELTASH2-PTP2C in Escherichia coli Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
H3VO4 slight effect Homo sapiens
heparin
-
Homo sapiens
Zn2+
-
Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ 4-6fold increase of activity Homo sapiens
Mg2+ 4-6fold increase of activity Homo sapiens
Mn2+ 4-6fold increase of activity Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
68000
-
PTP2C, gel filtration Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrophenyl phosphate + H2O
-
Homo sapiens 4-nitrophenol + phosphate
-
?
ENDpYINASL + H2O
-
Homo sapiens ENDYINASL + phosphate
-
?
lysozyme + H2O reduced, carboxymethylated and maleylated Homo sapiens ? + phosphate
-
?
myelin basic protein + H2O
-
Homo sapiens ? + phosphate
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5 5.6 substrates 4-nitrophenyl phosphate and ENDpYINASL, enzymes PTP2C and DELTASH2-PTP2C Homo sapiens
6.5 7.5 substrates lysozyme and myelin basic protein, enzymes PTP2C and DELTASH2-PTP2C Homo sapiens