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Literature summary for 3.1.3.48 extracted from

  • Allsup, D.; Harris, R.; Baker, P.; Cawley, J.
    Protein-tyrosine phosphatase activity maintains the viability of hairy cells and modulates their response to interferon-alpha (2008), Leuk. Lymphoma, 49, 2351-2358.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
mpV(pic) potent and selective PTP inhibitor, inhibits SPH-1 in a dose-dependent manner Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
protein G-Sepharose column chromatography Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
B-lymphocyte
-
Homo sapiens
-
chronic lymphocytic leukemia cell
-
Homo sapiens
-
hairy cell leukemia cell HCL cells display increased expression of the phosphatases SPH-1 and SPH-2 as compared with normal B-lymphocytes, HCL cells require protein-tyrosine phosphatase activity for preservation of their viability Homo sapiens
-
hairy-cell leukemia cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrophenyl phosphate + H2O
-
Homo sapiens 4-nitrophenol + phosphate
-
?

Synonyms

Synonyms Comment Organism
protein-tyrosine phosphatase
-
Homo sapiens
PTP
-
Homo sapiens
SPH-1
-
Homo sapiens
SPH-2
-
Homo sapiens