Inhibitors | Comment | Organism | Structure |
---|---|---|---|
mpV(pic) | potent and selective PTP inhibitor, inhibits SPH-1 in a dose-dependent manner | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
protein G-Sepharose column chromatography | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
B-lymphocyte | - |
Homo sapiens | - |
chronic lymphocytic leukemia cell | - |
Homo sapiens | - |
hairy cell leukemia cell | HCL cells display increased expression of the phosphatases SPH-1 and SPH-2 as compared with normal B-lymphocytes, HCL cells require protein-tyrosine phosphatase activity for preservation of their viability | Homo sapiens | - |
hairy-cell leukemia cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-nitrophenyl phosphate + H2O | - |
Homo sapiens | 4-nitrophenol + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
protein-tyrosine phosphatase | - |
Homo sapiens |
PTP | - |
Homo sapiens |
SPH-1 | - |
Homo sapiens |
SPH-2 | - |
Homo sapiens |