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Literature summary for 3.1.3.48 extracted from

  • Wu, J.; Katrekar, A.; Honigberg, L.A.; Smith, A.M.; Conn, M.T.; Tang, J.; Jeffery, D.; Mortara, K.; Sampang, J.; Williams, S.R.; Buggy, J.; Clark, J.M.
    Identification of substrates of human protein-tyrosine phosphatase PTPN22 (2006), J. Biol. Chem., 281, 11002-11010.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
D195A/C227S optimized substrate-trap mutant, used for identification of physiological enzyme substrates Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble isolation from cell lysate Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
phosphorylated CD3 epsilon + H2O Homo sapiens
-
CD3 epsilon + phosphate
-
?
phosphorylated Lck + H2O Homo sapiens component of the T cell receptor signaling pathway Lck + phosphate
-
?
phosphorylated T cell antigen receptor zeta + H2O Homo sapiens
-
T cell antigen receptor zeta + phosphate
-
?
phosphorylated valosin containing protein + H2O Homo sapiens
-
valosin containing protein + phosphate
-
?
phosphorylated Vav + H2O Homo sapiens component of the T cell receptor signaling pathway Vav + phosphate
-
?
phosphorylated Zap70 + H2O Homo sapiens protein-tyrosine kinase Zap70 + phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
isoform PTPN22, expressed exclusively in cells of hematopoietic origin
-

Source Tissue

Source Tissue Comment Organism Textmining
JURKAT cell pervanadate-stimulated Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphorylated CD3 epsilon + H2O
-
Homo sapiens CD3 epsilon + phosphate
-
?
phosphorylated Lck + H2O component of the T cell receptor signaling pathway Homo sapiens Lck + phosphate
-
?
phosphorylated T cell antigen receptor zeta + H2O
-
Homo sapiens T cell antigen receptor zeta + phosphate
-
?
phosphorylated valosin containing protein + H2O
-
Homo sapiens valosin containing protein + phosphate
-
?
phosphorylated Vav + H2O component of the T cell receptor signaling pathway Homo sapiens Vav + phosphate
-
?
phosphorylated Zap70 + H2O protein-tyrosine kinase Homo sapiens Zap70 + phosphate
-
?

Synonyms

Synonyms Comment Organism
PTPN22
-
Homo sapiens