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Literature summary for 3.1.3.48 extracted from

  • Zabolotny, J.M.; Haj, F.G.; Kim, Y.B.; Kim, H.J.; Shulman, G.I.; Kim, J.K.; Neel, B.G.; Kahn, B.B.
    Transgenic overexpression of protein-tyrosine phosphatase 1B in muscle causes insulin resistance, but overexpression with leukocyte antigen-related phosphatase does not additively impair insulin action (2004), J. Biol. Chem., 279, 24844-24851.
    View publication on PubMed

Application

Application Comment Organism
medicine transgenic mice overexpressing enzyme in muscle at levels similar to those observed in insulin-resistant humans. Insulin-stimulated insulin receptor tyrosyl phosphorylation and phosphatidylinositol 3'-kinase activity are impaired by 35% and 40-60% resp. Whole body glucose disposal and muscle glucose uptake are decreased by 40-50% Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
transgenic expression in mice muscle
-

Synonyms

Synonyms Comment Organism
PTP1B
-
Homo sapiens