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Literature summary for 3.1.3.48 extracted from

  • Na, M.; Oh, W.K.; Kim, Y.H.; Cai, X.F.; Kim, S.; Kim, B.Y.; Ahn, J.S.
    Na, M.; Yang, S.; He, L.; Oh, H.; Kim, B.S.; Oh, W.K.; Kim, B.Y.; Ahn, J.S.: Inhibition of protein tyrosine phosphatase 1B by ursane-type triterpenes isolated from Symplocos paniculata (2006), Planta Med., 72, 261-263.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2alpha,3alpha,19alpha,23-tetrahydroxyurs-12-en-28-oic acid 50% inhibition at 0.0421 mM Homo sapiens
corosolic acid 50% inhibition at 0.0072mM, mixed-type inhibition Homo sapiens
ursolic acid 50% inhibition at 0.0038 mM, competitive inhibition Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
protein isoform PTP1B
-

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.002
-
ursolic acid pH 6.0, 37°C Homo sapiens