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Literature summary for 3.1.3.48 extracted from

  • Tonks, N.K.; Diltz, C.D.; Fischer, E.H.
    Characterization of the major protein-tyrosine-phosphatases of human placenta (1988), J. Biol. Chem., 263, 6731-6737.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
2-mercaptoethanol activation Homo sapiens
2-mercaptoethylamine activation Homo sapiens
dithiothreitol activation Homo sapiens
EDTA activation Homo sapiens
glutathione activation Homo sapiens
spermidine activation Homo sapiens
spermine activation Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
diphosphate
-
Homo sapiens
H3VO4
-
Homo sapiens
heparin
-
Homo sapiens
molybdate
-
Homo sapiens
Zn2+
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00011
-
bovine serum albumin calculated as mM phosphate released, enzyme subtype 1B, cytoplasmic and membrane-bound form Homo sapiens
0.00014
-
myelin basic protein calculated as mM phosphate released, enzyme subtype 1A, cytoplasmic form Homo sapiens
0.00025
-
myelin basic protein calculated as mM phosphate released, enzyme subtype 1B, cytoplasmic and membrane-bound form Homo sapiens
0.00026
-
bovine serum albumin calculated as mM phosphate released, enzyme subtype 1A, cytoplasmic form Homo sapiens
0.00028
-
lysozyme calculated as mM phosphate released, enzyme subtype 1B, cytoplasmic and membrane-bound form Homo sapiens
0.00045
-
lysozyme calculated as mM phosphate released , enzyme subtype 1A, cytoplasmic form Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
NaF activation Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
phosphatase subtype 1A and 1B
-

Source Tissue

Source Tissue Comment Organism Textmining
placenta
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrophenyl phosphate + H2O
-
Homo sapiens 4-nitrophenol + phosphate
-
?
bovine serum albumin + H2O reduced, carboxamide methylated and succinylated Homo sapiens ? + phosphate
-
?
lysozyme + H2O reduced, carboxymethylated and maleylated Homo sapiens ? + phosphate
-
?
myelin basic protein + H2O
-
Homo sapiens ? + phosphate
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5 5.5 substrate 4-nitrophenyl phosphate, subtype 1A Homo sapiens
5.5 6 substrate 4-nitrophenyl phosphate, subtype 1B Homo sapiens
6.5
-
substrate lysozyme, enzyme subtypes 1A and 1B Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
additional information
-
-
Homo sapiens