Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(5R)-2-((carboxycarbonyl)amino)-5-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid | - |
Homo sapiens | |
(5S)-2-((carboxycarbonyl)amino)-5-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid | - |
Homo sapiens | |
2-((carboxycarbonyl)amino)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid | i.e. OATP | Homo sapiens | |
2-((carboxycarbonyl)amino)-5-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid | - |
Homo sapiens | |
2-((carboxycarbonyl)amino)-5-((4-fluoro-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid | - |
Homo sapiens | |
2-((carboxycarbonyl)amino)-5-((4-hydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid | - |
Homo sapiens | |
2-((carboxycarbonyl)amino)-5-((5-hydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P18031 | isoforms PTP1B and PTPbeta | - |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00017 | - |
2-((carboxycarbonyl)amino)-5-((5-hydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid | isoform PTP1B, mutant D48N, H 7.0, 25°C | Homo sapiens | |
0.00019 | - |
2-((carboxycarbonyl)amino)-5-((4-hydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid | isoform PTP1B, mutant D48N, pH 7.0, 25°C | Homo sapiens | |
0.00019 | - |
2-((carboxycarbonyl)amino)-5-((5-hydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid | isoform PTP1B, mutant R47N/D48N, pH 7.0, 25°C | Homo sapiens | |
0.0003 | - |
(5S)-2-((carboxycarbonyl)amino)-5-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid | isoform PTP1B, mutant D48N, pH 7.0, 25°C | Homo sapiens | |
0.00031 | - |
2-((carboxycarbonyl)amino)-5-((4-hydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid | isoform PTP1B, mutant R47N/D48N, pH 7.0, 25°C | Homo sapiens | |
0.00033 | - |
(5S)-2-((carboxycarbonyl)amino)-5-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid | isoform PTP1B, mutant R47N/D48N, pH 7.0, 25°C | Homo sapiens | |
0.00049 | - |
2-((carboxycarbonyl)amino)-5-((5-hydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid | isoform PTPbeta, pH 7.0, 25°C | Homo sapiens | |
0.00055 | - |
(5S)-2-((carboxycarbonyl)amino)-5-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid | isoform PTPbeta, pH 7.0, 25°C | Homo sapiens | |
0.00061 | - |
2-((carboxycarbonyl)amino)-5-((4-fluoro-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid | isoform PTP1B, mutant D48N, pH 7.0, 25°C | Homo sapiens | |
0.00061 | - |
2-((carboxycarbonyl)amino)-5-((4-hydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid | isoform PTP1B, pH 7.0, 25°C | Homo sapiens | |
0.00061 | - |
2-((carboxycarbonyl)amino)-5-((4-hydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid | isoform PTPbeta, pH 7.0, 25°C | Homo sapiens | |
0.00067 | - |
2-((carboxycarbonyl)amino)-5-((4-fluoro-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid | isoform PTP1B, mutant R47N/D48N, pH 7.0, 25°C | Homo sapiens | |
0.00073 | - |
2-((carboxycarbonyl)amino)-5-((4-fluoro-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid | isoform PTPbeta, pH 7.0, 25°C | Homo sapiens | |
0.00091 | - |
2-((carboxycarbonyl)amino)-5-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid | isoform PTP1B, mutant D48N, pH 7.0, 25°C | Homo sapiens | |
0.00094 | - |
2-((carboxycarbonyl)amino)-5-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid | isoform PTP1B, mutant R47N/D48N, pH 7.0, 25°C | Homo sapiens | |
0.00128 | - |
2-((carboxycarbonyl)amino)-5-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid | isoform PTPbeta, pH 7.0, 25°C | Homo sapiens | |
0.0038 | - |
2-((carboxycarbonyl)amino)-5-((4-hydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid | isoform PTPbeta, mutant N47R/N48D, pH 7.0, 25°C | Homo sapiens | |
0.019 | - |
2-((carboxycarbonyl)amino)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid | isoform PTP1B, mutant R47N/D48N, pH 7.0, 25°C | Homo sapiens | |
0.02 | - |
2-((carboxycarbonyl)amino)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid | isoform PTP1B, mutant D48N, pH 7.0, 25°C | Homo sapiens | |
0.023 | - |
(5R)-2-((carboxycarbonyl)amino)-5-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid | isoform PTP1B, mutant D48N, pH 7.0, 25°C | Homo sapiens | |
0.027 | - |
(5R)-2-((carboxycarbonyl)amino)-5-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid | isoform PTPbeta, pH 7.0, 25°C | Homo sapiens | |
0.03 | - |
(5R)-2-((carboxycarbonyl)amino)-5-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid | isoform PTP1B, mutant R47N/D48N, pH 7.0, 25°C | Homo sapiens | |
0.048 | - |
2-((carboxycarbonyl)amino)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid | isoform PTPbeta, pH 7.0, 25°C | Homo sapiens | |
0.057 | - |
(5S)-2-((carboxycarbonyl)amino)-5-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid | isoform PTPbeta, mutant N47R/N48D, pH 7.0, 25°C | Homo sapiens | |
0.064 | - |
2-((carboxycarbonyl)amino)-5-((5-hydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid | isoform PTP1B, pH 7.0, 25°C | Homo sapiens | |
0.08 | - |
2-((carboxycarbonyl)amino)-5-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid | isoform PTP1B, pH 7.0, 25°C | Homo sapiens | |
0.084 | - |
2-((carboxycarbonyl)amino)-5-((4-fluoro-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid | isoform PTPbeta, mutant N47R/N48D, pH 7.0, 25°C | Homo sapiens | |
0.088 | - |
2-((carboxycarbonyl)amino)-5-((5-hydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid | isoform PTPbeta, mutant N47R/N48D, pH 7.0, 25°C | Homo sapiens | |
0.1 | - |
2-((carboxycarbonyl)amino)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid | isoform PTP1B, pH 7.0, 25°C | Homo sapiens | |
0.1 | - |
(5R)-2-((carboxycarbonyl)amino)-5-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid | isoform PTP1B, pH 7.0, 25°C | Homo sapiens | |
0.1 | - |
(5R)-2-((carboxycarbonyl)amino)-5-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid | isoform PTPbeta, mutant N47R/D48N, pH 7.0, 25°C | Homo sapiens | |
0.109 | - |
2-((carboxycarbonyl)amino)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid | isoform PTPbeta, mutant N47R/N48D, pH 7.0, 25°C | Homo sapiens | |
0.113 | - |
(5S)-2-((carboxycarbonyl)amino)-5-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid | isoform PTP1B, pH 7.0, 25°C | Homo sapiens | |
0.115 | - |
2-((carboxycarbonyl)amino)-5-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid | isoform PTPbeta, mutant N47R/N48D, pH 7.0, 25°C | Homo sapiens | |
0.147 | - |
2-((carboxycarbonyl)amino)-5-((4-fluoro-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)-4,7-dihydro-5H-thieno(2,3-c)pyran-3-carboxylic acid | isoform PTP1B, pH 7.0, 25°C | Homo sapiens |