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Literature summary for 3.1.3.48 extracted from

  • Wang, V.; Davis, D.A.; Veeranna, R.P.; Haque, M.; Yarchoan, R.
    Characterization of the activation of protein tyrosine phosphatase, receptor-type, Z polypeptide 1 (PTPRZ1) by hypoxia inducible factor-2 alpha (2010), PLoS ONE, 5, e9641.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
up hypoxia inducible factor-2, HIF-2, preferential activation of PTPRZ1 by HIF-2, involving ELK1, an E26 transformation-specific factor that can bind to HIF-2alpha but not HIF-1alpha. A deletion mutation of one of the two Ets binding motifs located near the principal hypoxia response element similarly decreases activation of the PTPRZ1 promoter by HIF-2. IFand Ets both bind to motifs on the PTPRZ1 promoter and cooperate inpreferential upregulation of PTPRZ1, binding of HIF-2 and ELK1 to nearby sites on the PTPRZ1 promoter region, overview Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
carcinoma cell PTPRZ1 is overexpressed in a number of tumors Homo sapiens
-
glioblastoma cell
-
Homo sapiens
-
HEK-293T cell
-
Homo sapiens
-
HEP-3B cell
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
protein tyrosine phosphatase, receptor-type, Z polypeptide 1
-
Homo sapiens
PTPRZ1
-
Homo sapiens

General Information

General Information Comment Organism
malfunction PTPRZ1 is implicated in glioblastoma pathogenesis Homo sapiens