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Literature summary for 3.1.3.48 extracted from

  • Dechert, U.; Adam, M.; Harder, K.W.; Clark-Lewis, I.; Jirik, F.
    Characterization of protein tyrosine phosphatase SH-PTP2. Study of phosphopeptide substrates and possible regulatory role of SH2 domains (1984), J. Biol. Chem., 269, 5602-5611.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
full length form and a truncated form lacking the SH-domains and exhibiting a higher catalytic activity, GenBank, EMBL Data Bank L07527 Homo sapiens

General Stability

General Stability Organism
sensitive to freezing and thawing Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
H3VO4
-
Homo sapiens
heparin
-
Homo sapiens
molybdate
-
Homo sapiens
NaF slight inhibition Homo sapiens
Phenylarsine oxide
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.059 0.789 platelet-derived growth factor receptor value varies with the point of tyrosine phosphorylation, values for truncated enzyme reduced relative to wild-type form Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q06124 GenBank, EMBL Data Bank L07527
-

Storage Stability

Storage Stability Organism
-70°C, 20% glycerol, no loss of activity Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrophenyl phosphate + H2O
-
Homo sapiens 4-nitrophenol + phosphate
-
?
platelet-derived growth factor receptor + H2O
-
Homo sapiens ? + phosphate
-
?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.66 7.2 platelet-derived growth factor receptor value varies with the point ot tyrosine phosphorylation, values for truncated enzyme increased relative to wild-type form Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.3
-
-
Homo sapiens

pH Stability

pH Stability pH Stability Maximum Comment Organism
additional information
-
unstable in imidazole buffers Homo sapiens