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Literature summary for 3.1.3.48 extracted from

  • Dao, T.T.; Nguyen, P.H.; Thuong, P.T.; Kang, K.W.; Na, M.; Ndinteh, D.T.; Mbafor, J.T.; Oh, W.K.
    Pterocarpans with inhibitory effects on protein tyrosine phosphatase 1B from Erythrina lysistemon Hutch (2009), Phytochemistry, 70, 2053-2057.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
calopocarpin
-
Homo sapiens
erybraedin A
-
Homo sapiens
erylysins A i.e. 3''-hydroxy-2',2'-dimethylpyrano[6',5':3,4]-2'',2''-dimethyldihydropyrano[6'',5'':9,10]pterocarpan, a pterocarpan isolated from stem bark of Erythrina lysistemon, inhibits PTPB1 Homo sapiens
erylysins B i.e. furano[5',4':3,4]-9-hydroxy-10-prenylpterocarpan, a pterocarpan isolated from stem bark of Erythrina lysistemon, inhibits PTPB1 Homo sapiens
erysubin D
-
Homo sapiens
eryvarin D
-
Homo sapiens
isoneorautenol
-
Homo sapiens
additional information the substitution of prenyl groups on pterocarpans might be important for in vitro PTP1B inhibitory activity, and hydroxyl group attached to C-6a or an aldehyde group attached to C-8 may decrease this activity. No inhibition by erylysins C, i.e. 8-formyl-3,9-dihydroxy-4,10-diprenylpterocarpan, by cristacarpin, and by erystagallin C Homo sapiens
orientanol C
-
Homo sapiens
phaseollin
-
Homo sapiens
ursolic acid
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation recombinant enzyme Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrophenyl phosphate + H2O
-
Homo sapiens 4-nitrophenol + phosphate
-
?

Synonyms

Synonyms Comment Organism
protein tyrosine phosphatase 1B
-
Homo sapiens
PTPB1
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6
-
assay at Homo sapiens