Protein Variants | Comment | Organism |
---|---|---|
additional information | knockdown of SHP-1 by small interfering RNA suppresses the effect of guggulsterone on induction of SHP-1 and on the inhibition of STAT3 activation | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
vanadate | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
additional information | SHP-1 is a nontransmembrane protein tyrosine phosphatase expressed in most cells | Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphotyrosyl-STAT3 + H2O | Homo sapiens | signal transducers and activator of transcription 3, STAT3, is a transcription factor that is associated with survival, proliferation, chemoresistance, and angiogenesis of tumor cells | STAT3 + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | - |
Homo sapiens | - |
MM1-S cell | a melphalan-sensitive myeloma cell line, from the peripheral blood cells of a patient with IgA myeloma, secretes lambda L chain, is negative for the presence of the EBV genome, and expresses leukocyte antigen DR, plasma cell Ag-1, and T9 and T10 antigens | Homo sapiens | - |
additional information | SHP-1 is a nontransmembrane protein tyrosine phosphatase expressed in most cells | Homo sapiens | - |
myeloma cell | - |
Homo sapiens | - |
SCC-4 cell | a head and neck squamous cell carcinoma cell line | Homo sapiens | - |
U-266 cell | a plasmacytoma of B-cell origin producing monoclonal antibodies and interleukin-6 | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphotyrosyl-STAT3 + H2O | - |
Homo sapiens | STAT3 + phosphate | - |
? | |
phosphotyrosyl-STAT3 + H2O | signal transducers and activator of transcription 3, STAT3, is a transcription factor that is associated with survival, proliferation, chemoresistance, and angiogenesis of tumor cells | Homo sapiens | STAT3 + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
protein tyrosine phosphatase SHP-1 | - |
Homo sapiens |
PTPase | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | guggulsterone, a farnesoid X receptor antagonist, induces the expression of both the protein and mRNA for tyrosine protein phosphatase SHP-1, which is not due to demethylation of the SHP-1 promoter previously implicated in the epigenetic silencing of SHP-1. Induction of SHP-1 leads to inhibition of activation of protein tyrosine kinases Janus-activated kinase 2 and c-Src, and of subsequent activation of STAT3, overview | up |
General Information | Comment | Organism |
---|---|---|
physiological function | SHP-1 is important in the negative regulation of JAK/STAT signaling and is often silenced by methylation in leukemias and lymphomas | Homo sapiens |