Cloned (Comment) | Organism |
---|---|
- |
Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
E76K | leukemia-associated Shp2 mutant | Homo sapiens |
R362K | the Shp2 mutant shows a strongly decreased affinity for the inhibitor phenylhydrazonopyrazolone sulfonate 1 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
orthovanadate | - |
Homo sapiens | |
phenylhydrazonopyrazolone sulfonate 1 | potent, active site-directed small molecule inhibitor which is specific for Shp2 over the closely related tyrosine phosphatases Shp1 and PTP1B | Homo sapiens | |
phenylhydrazonopyrazolone sulfonate 4 | the most potent inhibitor of Shp2 which shows a specificity profile similar to phenylhydrazonopyrazolone sulfonate 1 | Homo sapiens | |
suramin | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-nitrophenyl phosphate + H2O | - |
Homo sapiens | 4-nitrophenol + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
protein tyrosine phosphatase | - |
Homo sapiens |
PTP1B | - |
Homo sapiens |
PTPN11 | - |
Homo sapiens |
SHP1 | - |
Homo sapiens |
SHP2 | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0007 | - |
orthovanadate | Ki value for inhibition of wild type Shp2 | Homo sapiens | |
0.00073 | - |
phenylhydrazonopyrazolone sulfonate 1 | Ki value for inhibition of wild type Shp2 | Homo sapiens | |
0.0053 | - |
suramin | Ki value for inhibition of wild type PTP1B | Homo sapiens | |
0.0057 | - |
suramin | Ki value for inhibition of wild type Shp2 | Homo sapiens | |
0.0058 | - |
phenylhydrazonopyrazolone sulfonate 1 | Ki value for inhibition of mutant Shp2 R362K | Homo sapiens | |
0.0058 | - |
phenylhydrazonopyrazolone sulfonate 1 | Ki value for inhibition of wild type PTP1B | Homo sapiens | |
0.0107 | - |
phenylhydrazonopyrazolone sulfonate 1 | Ki value for inhibition of wild type Shp1 | Homo sapiens |