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Literature summary for 3.1.3.48 extracted from

  • Harris, L.K.; Frumm, S.M.; Bishop, A.C.
    A general assay for monitoring the activities of protein tyrosine phosphatases in living eukaryotic cells (2013), Anal. Biochem., 435, 99-105.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Saccharomyces cerevisiae YPH499 cells Mus musculus
expressed in Saccharomyces cerevisiae YPH499 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
C215S phosphatase-dead mutant of PTP1B Homo sapiens
C216S phosphatase-dead mutant of TCPTP Homo sapiens
C231S phosphatase-dead mutant of PEST Homo sapiens
C433S phosphatase-dead mutant of PTPalpha Homo sapiens
C459S phosphatase-dead mutant of Shp2 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[a protein]-tyrosine phosphate + H2O Mus musculus
-
[a protein]-tyrosine + phosphate
-
?
[a protein]-tyrosine phosphate + H2O Homo sapiens
-
[a protein]-tyrosine + phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[a protein]-tyrosine phosphate + H2O
-
Mus musculus [a protein]-tyrosine + phosphate
-
?
[a protein]-tyrosine phosphate + H2O
-
Homo sapiens [a protein]-tyrosine + phosphate
-
?

Synonyms

Synonyms Comment Organism
PEST
-
Homo sapiens
protein tyrosine phosphatase
-
Mus musculus
protein tyrosine phosphatase
-
Homo sapiens
PTP
-
Mus musculus
PTP
-
Homo sapiens
PTPalpha
-
Homo sapiens
SHP2
-
Mus musculus
T-cell protein tyrosine phosphatase
-
Homo sapiens
TCPTP
-
Homo sapiens

General Information

General Information Comment Organism
physiological function the enzyme is capable of rescuing the effects of v-Src toxicity Mus musculus
physiological function the enzyme is capable of rescuing the effects of v-Src toxicity Homo sapiens