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Literature summary for 3.1.3.48 extracted from

  • Zhang, Y.N.; Zhang, W.; Hong, D.; Shi, L.; Shen, Q.; Li, J.Y.; Li, J.; Hu, L.H.
    Oleanolic acid and its derivatives: new inhibitor of protein tyrosine phosphatase 1B with cellular activities (2008), Bioorg. Med. Chem., 16, 8697-8705.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in CHO cells and L6 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
28-(10-decanoic)-oleanolic acid
-
Homo sapiens
28-(12-dodecanoic)-oleanolic acid
-
Homo sapiens
28-(2-acetic)-oleanolic acid
-
Homo sapiens
28-(4-butyric)-oleanolic acid
-
Homo sapiens
28-(6-hexanoic)-oleanolic acid
-
Homo sapiens
28-(8-octanoic)-oleanolic acid
-
Homo sapiens
28-(glycine)-oleanolic acid amide
-
Homo sapiens
28-(L-glutamic acid)-oleanolic acid amide
-
Homo sapiens
28-(L-phenylalanine)-oleanolic acid amide
-
Homo sapiens
28-(p-carboxyphenyl)-oleanolic acid amide
-
Homo sapiens
28-[4-butyric((R)-1-carboxy-phenylethyl)-amide]-DELTA12-oleanene
-
Homo sapiens
28-[4-butyric((S)-1-carboxy-3-indole-ethyl)-amide]-DELTA12-oleanene
-
Homo sapiens
28-[4-butyric((S)-1-carboxy-5-imidazole-ethyl)-amide]-DELTA12-oleanene
-
Homo sapiens
28-[4-butyric((S)-1-carboxy-methylthioethyl)-amide]-DELTA12-oleanene
-
Homo sapiens
28-[4-butyric((S)-1-carboxy-phenylethyl)-amide]-DELTA12-oleanene
-
Homo sapiens
28-[4-butyric(1-carboxy-2,3-dimethoxyphenylethyl)-amide]-DELTA12-oleanene
-
Homo sapiens
28-[4-butyric(1-carboxy-3,4-dimethoxyphenylethyl)-amide]-DELTA12-oleanene
-
Homo sapiens
28-[4-butyric(1-carboxy-3,4-oxymethyleneoxyphenylethyl)-amide]-DELTA12-oleanene
-
Homo sapiens
28-[4-butyric(1-carboxy-3,5-dimethoxyphenylethyl)-amide]-DELTA12-oleanene
-
Homo sapiens
28-[4-butyric(1-carboxy-m-chlorophenylethyl)-amide]-DELTA12-oleanene
-
Homo sapiens
28-[4-butyric(1-carboxy-m-methoxyphenylethyl)-amide]-DELTA12-oleanene
-
Homo sapiens
28-[4-butyric(1-carboxy-o-chlorophenylethyl)-amide]-DELTA12-oleanene
-
Homo sapiens
28-[4-butyric(1-carboxy-o-methoxyphenylethyl)-amide]-DELTA12-oleanene
-
Homo sapiens
28-[4-butyric(1-carboxy-o-methylphenylethyl)-amide]-DELTA12-oleanene
-
Homo sapiens
28-[4-butyric(1-carboxy-p-chlorophenylethyl)-amide]-DELTA12-oleanene
-
Homo sapiens
28-[4-butyric(1-carboxy-p-fluorophenylethyl)-amide]-DELTA12-oleanene
-
Homo sapiens
28-[4-butyric(1-carboxy-p-methoxyphenylethyl)-amide]-DELTA12-oleanene
-
Homo sapiens
28-[4-butyric(1-carboxy-p-methylphenylethyl)-amide]-DELTA12-oleanene
-
Homo sapiens
28-[4-butyric(1-carboxy-p-nitrophenylethyl)-amide]-DELTA12-oleanene
-
Homo sapiens
3-(2,2'-dimethyl-carboxypropanoyloxy)-oleanolic acid
-
Homo sapiens
3-(2-carboxy-benzyloxy)-oleanolic acid
-
Homo sapiens
3-(2-carboxybenzoyloxy)-oleanolic acid
-
Homo sapiens
3-(3-carboxy-benzyloxy)-oleanolic acid
-
Homo sapiens
3-(4-carboxy-benzyloxy)-28-[4-butyric((s)-1-carboxyphenylethyl)-amide]-DELTA12-oleanene
-
Homo sapiens
3-(4-carboxy-benzyloxy)-oleanolic acid
-
Homo sapiens
3-benzyloxy-oleanolic acid
-
Homo sapiens
3-carboxypropanoyloxy-oleanolic acid
-
Homo sapiens
3-dehydroxy-oleanolic acid
-
Homo sapiens
3-ethyl oxalyl-oleanolic acid
-
Homo sapiens
3-methylene-oleanolic acid
-
Homo sapiens
3-oxalyl-oleanolic acid
-
Homo sapiens
3-oxo-oleanolic acid
-
Homo sapiens
3alpha-oleanolic acid
-
Homo sapiens
4,4'-[benzene-1,4-diylbis(methanediyloxy)]dibenzoic acid
-
Homo sapiens
benzyl oleanolic acid amide
-
Homo sapiens
benzyl oleanolic acid ester
-
Homo sapiens
methyl oleanolic acid amide
-
Homo sapiens
methyl oleanolic acid ester
-
Homo sapiens
oleanolic acid
-
Homo sapiens
oleanolic acid amide
-
Homo sapiens
oleanolic alcohol
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P29350
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphorylated insulin receptor + H2O
-
Homo sapiens insulin receptor + phosphate
-
?

Synonyms

Synonyms Comment Organism
protein tyrosine phosphatase 1B
-
Homo sapiens
PTP1B
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00015
-
-
Homo sapiens 3-(4-carboxy-benzyloxy)-28-[4-butyric((s)-1-carboxyphenylethyl)-amide]-DELTA12-oleanene
0.00044
-
-
Homo sapiens 28-[4-butyric(1-carboxy-3,4-oxymethyleneoxyphenylethyl)-amide]-DELTA12-oleanene
0.00045
-
-
Homo sapiens 28-[4-butyric(1-carboxy-p-nitrophenylethyl)-amide]-DELTA12-oleanene
0.00051
-
-
Homo sapiens 28-[4-butyric(1-carboxy-m-chlorophenylethyl)-amide]-DELTA12-oleanene
0.00052
-
-
Homo sapiens 28-[4-butyric(1-carboxy-m-methoxyphenylethyl)-amide]-DELTA12-oleanene
0.00053
-
-
Homo sapiens 28-[4-butyric(1-carboxy-o-methoxyphenylethyl)-amide]-DELTA12-oleanene
0.00054
-
-
Homo sapiens 3-(4-carboxy-benzyloxy)-oleanolic acid
0.00055
-
-
Homo sapiens 28-[4-butyric((S)-1-carboxy-methylthioethyl)-amide]-DELTA12-oleanene
0.00055
-
-
Homo sapiens 28-[4-butyric(1-carboxy-o-methylphenylethyl)-amide]-DELTA12-oleanene
0.00056
-
-
Homo sapiens 28-[4-butyric(1-carboxy-o-chlorophenylethyl)-amide]-DELTA12-oleanene
0.00057
-
-
Homo sapiens 28-[4-butyric((S)-1-carboxy-phenylethyl)-amide]-DELTA12-oleanene
0.00057
-
-
Homo sapiens 28-[4-butyric(1-carboxy-p-fluorophenylethyl)-amide]-DELTA12-oleanene
0.00059
-
-
Homo sapiens 28-(12-dodecanoic)-oleanolic acid
0.00059
-
-
Homo sapiens 28-[4-butyric((S)-1-carboxy-3-indole-ethyl)-amide]-DELTA12-oleanene
0.0006
-
-
Homo sapiens 28-[4-butyric(1-carboxy-p-methoxyphenylethyl)-amide]-DELTA12-oleanene
0.00061
-
-
Homo sapiens 28-[4-butyric(1-carboxy-p-chlorophenylethyl)-amide]-DELTA12-oleanene
0.00062
-
-
Homo sapiens 3-(3-carboxy-benzyloxy)-oleanolic acid
0.00063
-
-
Homo sapiens 28-[4-butyric(1-carboxy-3,5-dimethoxyphenylethyl)-amide]-DELTA12-oleanene
0.00065
-
-
Homo sapiens 28-[4-butyric(1-carboxy-p-methylphenylethyl)-amide]-DELTA12-oleanene
0.00066
-
-
Homo sapiens 28-[4-butyric(1-carboxy-2,3-dimethoxyphenylethyl)-amide]-DELTA12-oleanene
0.00072
-
-
Homo sapiens 28-(10-decanoic)-oleanolic acid
0.00074
-
-
Homo sapiens 28-[4-butyric((R)-1-carboxy-phenylethyl)-amide]-DELTA12-oleanene
0.00078
-
-
Homo sapiens 28-(8-octanoic)-oleanolic acid
0.00082
-
-
Homo sapiens 28-[4-butyric(1-carboxy-3,4-dimethoxyphenylethyl)-amide]-DELTA12-oleanene
0.00088
-
-
Homo sapiens 28-(6-hexanoic)-oleanolic acid
0.00133
-
-
Homo sapiens 28-(4-butyric)-oleanolic acid
0.0021
-
-
Homo sapiens 28-(2-acetic)-oleanolic acid
0.00233
-
-
Homo sapiens 3-(2,2'-dimethyl-carboxypropanoyloxy)-oleanolic acid
0.00261
-
-
Homo sapiens 3-dehydroxy-oleanolic acid
0.00267
-
-
Homo sapiens 3-benzyloxy-oleanolic acid
0.00272
-
-
Homo sapiens 3-(2-carboxy-benzyloxy)-oleanolic acid
0.00285
-
-
Homo sapiens 3-methylene-oleanolic acid
0.00286
-
-
Homo sapiens 3-oxalyl-oleanolic acid
0.00289
-
-
Homo sapiens 3-ethyl oxalyl-oleanolic acid
0.00319
-
-
Homo sapiens 28-(p-carboxyphenyl)-oleanolic acid amide
0.00331
-
-
Homo sapiens 28-(L-phenylalanine)-oleanolic acid amide
0.0037
-
-
Homo sapiens oleanolic acid
0.00444
-
-
Homo sapiens methyl oleanolic acid ester
0.00458
-
-
Homo sapiens 3-(2-carboxybenzoyloxy)-oleanolic acid
0.00462
-
-
Homo sapiens 28-[4-butyric((S)-1-carboxy-5-imidazole-ethyl)-amide]-DELTA12-oleanene
0.00476
-
-
Homo sapiens oleanolic acid amide
0.00505
-
-
Homo sapiens 3alpha-oleanolic acid
0.00532
-
-
Homo sapiens 3-oxo-oleanolic acid
0.00573
-
-
Homo sapiens 4,4'-[benzene-1,4-diylbis(methanediyloxy)]dibenzoic acid
0.00597
-
-
Homo sapiens 3-carboxypropanoyloxy-oleanolic acid
0.0081
-
-
Homo sapiens benzyl oleanolic acid amide
0.00861
-
-
Homo sapiens benzyl oleanolic acid ester
0.0092
-
-
Homo sapiens methyl oleanolic acid amide
0.01544
-
-
Homo sapiens 28-(glycine)-oleanolic acid amide
0.01635
-
-
Homo sapiens 28-(L-glutamic acid)-oleanolic acid amide
0.02
-
IC50 above 0.02 mM Homo sapiens oleanolic alcohol