Application | Comment | Organism |
---|---|---|
drug development | PTP1B is a target for drug development in treatment of type II diabetes and obesity | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
lupenone | isolated from Sorbus commixta stem bark, inhibits PTP1B in a selective and noncompetitive manner | Homo sapiens | |
lupeol | isolated from Sorbus commixta stem bark, inhibits PTP1B in a selective and noncompetitive manner | Homo sapiens | |
RK-682 | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | recombinant PTPB1 | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-nitrophenyl phosphate + H2O | - |
Homo sapiens | 4-nitrophenol + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
protein tyrosine phosphatase 1B | - |
Homo sapiens |
PTP1B | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6 | - |
assay at | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | inhibition kinetics | Homo sapiens | |
0.0034 | - |
lupeol | pH 6.0, 37°C | Homo sapiens | |
0.0118 | - |
lupenone | pH 6.0, 37°C | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0045 | - |
pH 6.0, 37°C | Homo sapiens | RK-682 | |
0.0056 | - |
pH 6.0, 37°C | Homo sapiens | lupeol | |
0.0137 | - |
pH 6.0, 37°C | Homo sapiens | lupenone |