Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.3.48 extracted from

  • Kwon, J.H.; Chang, M.J.; Seo, H.W.; Lee, J.H.; Min, B.S.; Na, M.; Kim, J.C.; Woo, M.H.; Choi, J.S.; Lee, H.K.; Bae, K.
    Triterpenoids and a sterol from the stem-bark of Styrax japonica and their protein tyrosine phosphatase 1B inhibitory activities (2008), Phytother. Res., 22, 1303-1306.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
3beta-acetoxy-17beta-hydroxy-28-norolean-12-ene
-
Homo sapiens
3beta-acetoxy-28-hydroxyolean-12-ene
-
Homo sapiens
3beta-acetoxyolean-12-en-28-acid
-
Homo sapiens
3beta-acetoxyolean-12-en-28-aldehyde
-
Homo sapiens
3beta-hydroxyolean-12-en-28-oic acid
-
Homo sapiens
glycyrrhetic acid
-
Homo sapiens
RK-682
-
Homo sapiens
stigmasterol
-
Homo sapiens
taraxerol
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrophenyl phosphate + H2O
-
Homo sapiens 4-nitrophenol + phosphate
-
?

Synonyms

Synonyms Comment Organism
protein tyrosine phosphatase 1B
-
Homo sapiens
PTP1B
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0045
-
in 50 mM citrate (pH 6.0), 0.1 M NaCl, 1 mM EDTA, and 1 mM dithiothreitol, at 37°C Homo sapiens RK-682
0.0052
-
in 50 mM citrate (pH 6.0), 0.1 M NaCl, 1 mM EDTA, and 1 mM dithiothreitol, at 37°C Homo sapiens 3beta-hydroxyolean-12-en-28-oic acid
0.0078
-
in 50 mM citrate (pH 6.0), 0.1 M NaCl, 1 mM EDTA, and 1 mM dithiothreitol, at 37°C Homo sapiens 3beta-acetoxyolean-12-en-28-acid
0.0093
-
in 50 mM citrate (pH 6.0), 0.1 M NaCl, 1 mM EDTA, and 1 mM dithiothreitol, at 37°C Homo sapiens 3beta-acetoxyolean-12-en-28-aldehyde
0.0138
-
in 50 mM citrate (pH 6.0), 0.1 M NaCl, 1 mM EDTA, and 1 mM dithiothreitol, at 37°C Homo sapiens glycyrrhetic acid
0.044
-
in 50 mM citrate (pH 6.0), 0.1 M NaCl, 1 mM EDTA, and 1 mM dithiothreitol, at 37°C Homo sapiens 3beta-acetoxy-28-hydroxyolean-12-ene
0.05
-
IC50 above 0.05 mM, in 50 mM citrate (pH 6.0), 0.1 M NaCl, 1 mM EDTA, and 1 mM dithiothreitol, at 37°C Homo sapiens stigmasterol
0.05
-
IC50 above 0.05 mM, in 50 mM citrate (pH 6.0), 0.1 M NaCl, 1 mM EDTA, and 1 mM dithiothreitol, at 37°C Homo sapiens taraxerol
0.05
-
IC50 above 0.05 mM, in 50 mM citrate (pH 6.0), 0.1 M NaCl, 1 mM EDTA, and 1 mM dithiothreitol, at 37°C Homo sapiens 3beta-acetoxy-17beta-hydroxy-28-norolean-12-ene