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Literature summary for 3.1.3.48 extracted from

  • Meng, F.G.; Zhang, Z.Y.
    Redox regulation of protein tyrosine phosphatase activity by hydroxyl radical (2013), Biochim. Biophys. Acta, 1834, 464-469.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.3.48

Inhibitors

Inhibitors Comment Organism Structure
H2O2 the enzyme can be more rapidly inactivated by H2O2 in the absence of EDTA Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[a protein]-tyrosine phosphate + H2O Homo sapiens
-
 [a protein]-tyrosine + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrophenyl phosphate + H2O
-
 Homo sapiens 4-nitrophenol + phosphate
-
 ?
[a protein]-tyrosine phosphate + H2O
-
 Homo sapiens [a protein]-tyrosine + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
CD45
-
 Homo sapiens
HEPTP
-
 Homo sapiens
protein tyrosine phosphatase
-
 Homo sapiens
PTP1B
-
 Homo sapiens
PTPalpha
-
 Homo sapiens
VHR
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.006
-
 H2O2 PTP1B, in 50 mM 3,3-dimethylglutarate (pH 6.0), at 25°C Homo sapiens
0.0074
-
 H2O2 CD45, in 50 mM 3,3-dimethylglutarate (pH 6.0), at 25°C Homo sapiens
0.0075
-
 H2O2 HePTP, in 50 mM 3,3-dimethylglutarate (pH 6.0), at 25°C Homo sapiens
0.0294
-
 H2O2 VHR, in 50 mM 3,3-dimethylglutarate (pH 6.0), at 25°C Homo sapiens
0.196
-
 H2O2 PTPalpha, in 50 mM 3,3-dimethylglutarate (pH 6.0), at 25°C Homo sapiens