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Literature summary for 3.1.3.48 extracted from

  • Yoon, G.; Lee, W.; Kim, S.N.; Cheon, S.H.
    Inhibitory effect of chalcones and their derivatives from Glycyrrhiza inflata on protein tyrosine phosphatase 1B (2009), Bioorg. Med. Chem. Lett., 19, 5155-5157.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(2E)-1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one isolated from the CH2Cl2 extract of Glycyrrhiza inflata Homo sapiens
(2E)-3-(4-hydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one isolated from the CH2Cl2 extract of Glycyrrhiza inflata Homo sapiens
(2E)-3-[2,4-dimethoxy-5-(2-methylbut-3-en-2-yl)phenyl]-1-(4-hydroxyphenyl)prop-2-en-1-one a semisynthetic licochalcone A derivative Homo sapiens
(2E)-3-[2,4-dimethoxy-5-(2-methylbut-3-en-2-yl)phenyl]-1-(4-methoxyphenyl)prop-2-en-1-one a semisynthetic licochalcone A derivative Homo sapiens
(2E)-3-[4-hydroxy-2-methoxy-3-(3-methylbut-2-en-1-yl)phenyl]-1-(4-hydroxyphenyl)prop-2-en-1-one isolated from the CH2Cl2 extract of Glycyrrhiza inflata Homo sapiens
(2E)-3-[4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)phenyl]-1-(4-hydroxyphenyl)prop-2-en-1-one isolated from the CH2Cl2 extract of Glycyrrhiza inflata Homo sapiens
(2E)-3-[4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)phenyl]-1-(4-methoxyphenyl)prop-2-en-1-one a semisynthetic licochalcone A derivative Homo sapiens
(2E)-3-[4-hydroxy-2-methoxy-5-(3-methylbut-3-en-2-yl)phenyl]-1-(4-hydroxyphenyl)prop-2-en-1-one isolated from the CH2Cl2 extract of Glycyrrhiza inflata Homo sapiens
4-[(1E)-3-(4-hydroxyphenyl)-3-oxoprop-1-en-1-yl]-5-methoxy-2-(2-methylbut-3-en-2-yl)phenyl acetate a semisynthetic licochalcone A derivative Homo sapiens
4-[(2E)-3-[2,4-dimethoxy-5-(2-methylbut-3-en-2-yl)phenyl]prop-2-enoyl]phenyl acetate a semisynthetic licochalcone A derivative Homo sapiens
4-[(2E)-3-[4-(acetyloxy)-2-methoxy-5-(2-methylbut-3-en-2-yl)phenyl]prop-2-enoyl]phenyl acetate a semisynthetic licochalcone A derivative Homo sapiens
4-[(2E)-3-[4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)phenyl]prop-2-enoyl]phenyl acetate a semisynthetic licochalcone A derivative Homo sapiens
5-methoxy-4-[(1E)-3-(4-methoxyphenyl)-3-oxoprop-1-en-1-yl]-2-(2-methylbut-3-en-2-yl)phenyl acetate a semisynthetic licochalcone A derivative Homo sapiens
7-hydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4H-chromen-4-one isolated from the CH2Cl2 extract of Glycyrrhiza inflata Homo sapiens
ursolic acid
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrophenylphosphate + H2O
-
Homo sapiens 4-nitrophenol + phosphate
-
?

Synonyms

Synonyms Comment Organism
protein tyrosine phosphatase 1B
-
Homo sapiens
PTP1B
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6
-
assay at Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0117
-
pH 6.0, 37°C Homo sapiens (2E)-3-[4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)phenyl]-1-(4-methoxyphenyl)prop-2-en-1-one
0.0173
-
pH 6.0, 37°C Homo sapiens 4-[(1E)-3-(4-hydroxyphenyl)-3-oxoprop-1-en-1-yl]-5-methoxy-2-(2-methylbut-3-en-2-yl)phenyl acetate
0.0183
-
pH 6.0, 37°C Homo sapiens (2E)-3-[2,4-dimethoxy-5-(2-methylbut-3-en-2-yl)phenyl]-1-(4-hydroxyphenyl)prop-2-en-1-one
0.0191
-
pH 6.0, 37°C Homo sapiens (2E)-3-[4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)phenyl]-1-(4-hydroxyphenyl)prop-2-en-1-one
0.0192
-
pH 6.0, 37°C Homo sapiens 4-[(2E)-3-[4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)phenyl]prop-2-enoyl]phenyl acetate
0.0194
-
pH 6.0, 37°C Homo sapiens 5-methoxy-4-[(1E)-3-(4-methoxyphenyl)-3-oxoprop-1-en-1-yl]-2-(2-methylbut-3-en-2-yl)phenyl acetate
0.0198
-
pH 6.0, 37°C Homo sapiens (2E)-3-[2,4-dimethoxy-5-(2-methylbut-3-en-2-yl)phenyl]-1-(4-methoxyphenyl)prop-2-en-1-one
0.0207
-
pH 6.0, 37°C Homo sapiens (2E)-3-[4-hydroxy-2-methoxy-5-(3-methylbut-3-en-2-yl)phenyl]-1-(4-hydroxyphenyl)prop-2-en-1-one
0.0292
-
pH 6.0, 37°C Homo sapiens 4-[(2E)-3-[2,4-dimethoxy-5-(2-methylbut-3-en-2-yl)phenyl]prop-2-enoyl]phenyl acetate
0.0309
-
pH 6.0, 37°C Homo sapiens (2E)-3-[4-hydroxy-2-methoxy-3-(3-methylbut-2-en-1-yl)phenyl]-1-(4-hydroxyphenyl)prop-2-en-1-one
0.05
-
above, pH 6.0, 37°C Homo sapiens 4-[(2E)-3-[4-(acetyloxy)-2-methoxy-5-(2-methylbut-3-en-2-yl)phenyl]prop-2-enoyl]phenyl acetate
0.05
-
above, pH 6.0, 37°C Homo sapiens 7-hydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4H-chromen-4-one
0.05
-
above, pH 6.0, 37°C Homo sapiens (2E)-3-(4-hydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one
0.05
-
above, pH 6.0, 37°C Homo sapiens (2E)-1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one