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Literature summary for 3.1.3.48 extracted from

  • Lee, H.; Xie, L.; Luo, Y.; Lee, S.Y.; Lawrence, D.S.; Wang, X.B.; Sotgia, F.; Lisanti, M.P.; Zhang, Z.Y.
    Identification of phosphocaveolin-1 as a novel protein tyrosine phosphatase 1B substrate (2006), Biochemistry, 45, 234-240.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
D181A substrate-trapping mutant Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
N-((4-(difluoro(phosphono)methyl)phenyl)acetyl)-L-a-aspartyl-4-(difluoro(phosphono)methyl)-L-phenylalaninamide inhibition of enzyme increases caveolin-1 phosphorylation Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
phosphocaveolin-1 + H2O Homo sapiens phosphorylated at Y14 caveolin-1 + phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
isoform PTP1B
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphocaveolin-1 + H2O phosphorylated at Y14 Homo sapiens caveolin-1 + phosphate
-
?