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Literature summary for 3.1.3.48 extracted from

  • Pedersen, A.K.; Guo, X.L.; Moller, K.B.; Peters, G.H.; Andersen, H.S.; Kastrup, J.S.; Mortensen, S.B.; Iversen, L.F.; Zhang, Z.Y.; Moller, N.P.H.
    Residue 182 influences the second step of protein-tyrosine phosphatase-mediated catalysis (2004), Biochem. J., 378, 421-433.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

Crystallization (Comment) Organism
PTP1B and PTP1B mutant F182H in complex with inhibitors Homo sapiens

Protein Variants

Protein Variants Comment Organism
F182H isoform PTP1B, exchange of residue 182 with that of isoform PTPH1, modulation of functionality of catalytic center Homo sapiens
H182F isoform PTP1B, exchange of residue 182 with that of isoform PTPB1, modulation of functionality of catalytic center Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2-(oxalyl-amino)-4,5,6,7-tetrahydro-thieno[2,3-c]pyridine-3-carboxylic acid
-
Homo sapiens
2-(oxalyl-amino)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid
-
Homo sapiens
3-[oxalyl-amino]naphthalene-2-carboxylic acid
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1
-
acetyl-DADEpYL-NH2 pH 7.0, 30°C, isoform PTPH1 Homo sapiens
1.84
-
acetyl-DADEpYL-NH2 pH 7.0, 30°C, isoform PTP1B, mutant F182H Homo sapiens
4.04
-
acetyl-DADEpYL-NH2 pH 7.0, 30°C, isoform PTP1B Homo sapiens
97.5
-
acetyl-DADEpYL-NH2 pH 7.0, 30°C, isoform PTPH1, mutant H182F Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P18031 isoforms PTPB1, PTPH1
-

Reaction

Reaction Comment Organism Reaction ID
[a protein]-tyrosine phosphate + H2O = [a protein]-tyrosine + phosphate mechanism, role of residue 182 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-DADEpYL-NH2 + H2O
-
Homo sapiens acetyl-DADEYL-NH2 + phosphate
-
?

Synonyms

Synonyms Comment Organism
PTPB1
-
Homo sapiens
PTPH1
-
Homo sapiens