EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
3.1.4.37 | 2',3'-cyclic-nucleotide 3'-phosphodiesterase |
glioma cell |
- |
135401 |
3.1.3.7 | 3'(2'),5'-bisphosphate nucleotidase |
glioma cell |
in glioma tissues, phosphocholine(36:1) is not detected and 3'-phosphoadenylate (pAp) content is significantly increased. The gene expression of the 3'-nucleotidase 3'(2'),5'-bisphosphate nucleotidase 1 (BPNT-1) is dramatically downregulated, quantitative real-time polymerase chain reaction (qRT-PCR) expression analysis. Gene expression of enzymes associated with pAp metabolism |
752237 |
3.1.3.5 | 5'-nucleotidase |
glioma cell |
- |
694138 |
2.7.1.105 | 6-phosphofructo-2-kinase |
glioma cell |
- |
739621, 761915 |
3.1.3.77 | acireductone synthase |
glioma cell |
- |
751767 |
2.7.1.94 | acylglycerol kinase |
glioma cell |
- |
761230 |
3.4.24.82 | ADAMTS-4 endopeptidase |
glioma cell |
- |
638956 |
4.6.1.1 | adenylate cyclase |
glioma cell |
- |
694258 |
1.2.1.3 | aldehyde dehydrogenase (NAD+) |
glioma cell |
- |
741427 |
2.5.1.26 | alkylglycerone-phosphate synthase |
glioma cell |
- |
737578, 739210 |
2.4.1.101 | alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase |
glioma cell |
cell proliferation and migration analysis, overview |
759196 |
1.13.11.31 | arachidonate 12-lipoxygenase |
glioma cell |
- |
688759 |
1.13.11.34 | arachidonate 5-lipoxygenase |
glioma cell |
- |
688512 |
1.13.11.34 | arachidonate 5-lipoxygenase |
glioma cell |
high enzyme expression level |
686278 |
1.14.14.14 | aromatase |
glioma cell |
- |
726047 |
6.3.5.4 | asparagine synthase (glutamine-hydrolysing) |
glioma cell |
- |
745756 |
2.4.1.144 | beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase |
glioma cell |
- |
736507 |
2.4.1.38 | beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase |
glioma cell |
- |
685932, 718736 |
2.6.1.42 | branched-chain-amino-acid transaminase |
glioma cell |
- |
758657 |
1.14.15.18 | calcidiol 1-monooxygenase |
glioma cell |
- |
659811 |
2.7.11.11 | cAMP-dependent protein kinase |
glioma cell |
- |
662380 |
3.4.22.60 | caspase-7 |
glioma cell |
- |
700938 |
3.4.22.61 | caspase-8 |
glioma cell |
- |
664508 |
3.4.22.61 | caspase-8 |
glioma cell |
stem-cell-like and non-stem-cell-like glioma cell |
695401 |
3.4.22.61 | caspase-8 |
glioma cell |
stem-cell-like glioma cell, low enzyme expression levels due to hypermethylation of the CASP8 promoter, also expressed in non-stem-like glioma cell |
695401 |
3.4.22.62 | caspase-9 |
glioma cell |
- |
665736 |
3.4.22.1 | cathepsin B |
glioma cell |
astrocytic |
707558 |
3.4.22.15 | cathepsin L |
glioma cell |
- |
712921 |
2.7.8.11 | CDP-diacylglycerol-inositol 3-phosphatidyltransferase |
glioma cell |
- |
645316 |
2.8.2.17 | chondroitin 6-sulfotransferase |
glioma cell |
- |
761061 |
2.3.1.57 | diamine N-acetyltransferase |
glioma cell |
- |
757876 |
3.4.14.5 | dipeptidyl-peptidase IV |
glioma cell |
- |
703784 |
2.4.1.109 | dolichyl-phosphate-mannose-protein mannosyltransferase |
glioma cell |
of brain with subarachnoid spread. Distinct POMT1 alterations may contribute to a functional impairment of protein-omannosyltransferase activity. In individual tumor specimens selective alterations of the POMT1 gene may be compatible with clonal evolution of distinct sublocations |
689201 |
2.7.11.20 | elongation factor 2 kinase |
glioma cell |
- |
760810 |
3.4.21.B28 | fibroblast activation protein alpha subunit |
glioma cell |
- |
707629 |
3.4.21.B28 | fibroblast activation protein alpha subunit |
glioma cell |
increased enzyme expression in a subgroup of high-grade gliomas. The enzyme is expressed by several constituents of the glioblastoma microenvironment, including stromal non-malignant mesenchymal cells recruited to and/or activated in response to glioma growth |
755628 |
3.4.21.75 | Furin |
glioma cell |
- |
708753 |
4.3.2.9 | gamma-glutamylcyclotransferase |
glioma cell |
- |
735619 |
3.4.24.24 | gelatinase A |
glioma cell |
high expression level of MMP-2 increasing during growth |
683427 |
3.4.24.35 | gelatinase B |
glioma cell |
high expression level of MMP-9 increasing during growth |
683427 |
3.2.1.45 | glucosylceramidase |
glioma cell |
- |
751699 |
2.4.1.175 | glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase |
glioma cell |
CHSY1 is frequently upregulated in glioblastoma and correlates with high tumor grade and poor survival |
759875 |
2.4.1.224 | glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase |
glioma cell |
- |
759360 |
1.4.1.3 | glutamate dehydrogenase [NAD(P)+] |
glioma cell |
gene expression profiling reveals that GLUD2 is selectively and consistently upregulated in glioma cells harboring IDH mutations |
762783 |
6.3.1.2 | glutamine synthetase |
glioma cell |
- |
671608, 745832 |
2.1.2.1 | glycine hydroxymethyltransferase |
glioma cell |
expression of SHMT2 in ischemic tumor zones |
736882 |
1.14.14.18 | heme oxygenase (biliverdin-producing) |
glioma cell |
- |
690140 |
3.2.1.166 | heparanase |
glioma cell |
- |
693320, 759360 |
5.1.3.17 | heparosan-N-sulfate-glucuronate 5-epimerase |
glioma cell |
- |
759360 |
2.7.1.1 | hexokinase |
glioma cell |
hexokinase I, predominant in normal brain |
640259 |
2.7.1.1 | hexokinase |
glioma cell |
hexokinase II, increased in brain tumors, ethylnitrosourea-induced 36B-10 astrocytic F-344 rat brain tumor cell line |
640259 |
2.3.1.48 | histone acetyltransferase |
glioma cell |
- |
756850 |
2.4.1.212 | hyaluronan synthase |
glioma cell |
cell line |
395258 |
3.1.6.13 | iduronate-2-sulfatase |
glioma cell |
- |
650371 |
2.7.1.127 | inositol-trisphosphate 3-kinase |
glioma cell |
human glioma cell line HTB-138, InsP3 3-kinase B mRNA |
640751 |
1.1.1.41 | isocitrate dehydrogenase (NAD+) |
glioma cell |
- |
712180 |
1.1.1.42 | isocitrate dehydrogenase (NADP+) |
glioma cell |
- |
712180, 712574, 712614, 713113, 739984 |
1.1.1.42 | isocitrate dehydrogenase (NADP+) |
glioma cell |
IDH1, diffuse gliomas graded II-IV |
713508 |
1.1.1.42 | isocitrate dehydrogenase (NADP+) |
glioma cell |
of grade II-III gliomas |
713100 |
1.1.1.42 | isocitrate dehydrogenase (NADP+) |
glioma cell |
progressive gliomas |
711107 |
2.7.1.3 | ketohexokinase |
glioma cell |
expressed at significantly higher level in glioma tissues than in non-tumor brain |
758732 |
4.4.1.5 | lactoylglutathione lyase |
glioma cell |
- |
709654 |
3.3.2.6 | leukotriene-A4 hydrolase |
glioma cell |
- |
752495 |
1.1.1.40 | malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) |
glioma cell |
- |
761332 |
3.4.24.23 | matrilysin |
glioma cell |
highly variable MMP-7 expression in the glioma population |
683864 |
3.4.21.109 | matriptase |
glioma cell |
- |
717799 |
3.4.24.B4 | matrix metalloproteinase-13 |
glioma cell |
- |
711163 |
3.4.24.B7 | matrix metalloproteinase-26 |
glioma cell |
- |
713160, 754946 |
2.1.1.63 | methylated-DNA-[protein]-cysteine S-methyltransferase |
glioma cell |
- |
673219, 701644, 705897 |
2.1.1.63 | methylated-DNA-[protein]-cysteine S-methyltransferase |
glioma cell |
biopsies |
688740 |
2.7.12.2 | mitogen-activated protein kinase kinase |
glioma cell |
MKK3 i s upregulated and activated in invasive glioma cells in vitro, overexpression and phosphorylation of MKK3 are linked to glioma invasion, MKK3 is overexpressed in invasive glioma cells in situ and correlates with active p38 |
681871 |
1.4.3.4 | monoamine oxidase |
glioma cell |
activity selectively increases in MAO-B activity in human gliomas when compared with meningiomas or non-tumoural tissue |
689175 |
2.4.1.226 | N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase |
glioma cell |
CHSY1 is frequently upregulated in glioblastoma and correlates with high tumor grade and poor survival |
759875 |
2.4.1.225 | N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase |
glioma cell |
- |
759360 |
2.4.1.47 | N-acylsphingosine galactosyltransferase |
glioma cell |
human fetal glioma cell line |
489221 |
2.4.1.47 | N-acylsphingosine galactosyltransferase |
glioma cell |
N-370 FG cells |
489221, 489224 |
1.1.1.300 | NADP-retinol dehydrogenase |
glioma cell |
high RDH10 expression level, 13.89%, 43.59%, 70.59%, and 90.24% expression of RDH10 in glioma of grade I, II, III, and IV (WHO grading), respectively |
762073 |
2.4.2.12 | nicotinamide phosphoribosyltransferase |
glioma cell |
- |
735872 |
2.7.10.2 | non-specific protein-tyrosine kinase |
glioma cell |
- |
721489 |
3.6.1.9 | nucleotide diphosphatase |
glioma cell |
- |
246803 |
3.6.1.9 | nucleotide diphosphatase |
glioma cell |
homologue to plasma cell membrane glycoprotein PC-1 |
246804 |
4.1.1.17 | ornithine decarboxylase |
glioma cell |
- |
680217, 682982, 697101, 697861 |
2.7.1.137 | phosphatidylinositol 3-kinase |
glioma cell |
- |
709276 |
2.7.1.153 | phosphatidylinositol-4,5-bisphosphate 3-kinase |
glioma cell |
- |
709907 |
5.4.2.11 | phosphoglycerate mutase (2,3-diphosphoglycerate-dependent) |
glioma cell |
- |
748795 |
3.1.4.11 | phosphoinositide phospholipase C |
glioma cell |
C6Bu-1 rat glioma cell, isoenzyme PI-PLC-beta1 |
668867 |
3.1.4.4 | phospholipase D |
glioma cell |
- |
708012 |
2.1.2.2 | phosphoribosylglycinamide formyltransferase 1 |
glioma cell |
the enzyme is frequently overexpressed in glioma, enzyme immunohistochemic analysis in 70 cases of human gliomas and normal brain tissues, overview |
736945 |
3.2.1.143 | poly(ADP-ribose) glycohydrolase |
glioma cell |
primary culture, highest ratio of nuclear to cytoplasmic enzyme activity |
664476 |
3.4.21.26 | prolyl oligopeptidase |
glioma cell |
- |
669933, 683344 |
5.3.99.3 | prostaglandin-E synthase |
glioma cell |
- |
681868 |
2.7.11.13 | protein kinase C |
glioma cell |
- |
676323 |
3.1.1.89 | protein phosphatase methylesterase-1 |
glioma cell |
in human glioma cell, high PME-1 expression correlates with tumor progression and kinase inhibitor resistance |
749865 |
2.3.1.B41 | protein-long-chain fatty-acyl-lysine deacylase (NAD+) |
glioma cell |
SIRT6 is down-regulated in human glioma tissues |
729145 |
3.1.3.16 | protein-serine/threonine phosphatase |
glioma cell |
- |
692085, 750280 |
3.4.22.B70 | SENP1 peptidase |
glioma cell |
- |
753729 |
5.1.1.18 | serine racemase |
glioma cell |
- |
705283 |
2.3.1.299 | sphingoid base N-stearoyltransferase |
glioma cell |
- |
757888 |
1.14.19.17 | sphingolipid 4-desaturase |
glioma cell |
- |
744686 |
3.1.4.12 | sphingomyelin phosphodiesterase |
glioma cell |
C6-glioma cells |
652974 |