EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
3.1.4.37 | 2',3'-cyclic-nucleotide 3'-phosphodiesterase |
glioma cell |
- |
135401 |
3.6.1.9 | nucleotide diphosphatase |
glioma cell |
- |
246803 |
3.6.1.9 | nucleotide diphosphatase |
glioma cell |
homologue to plasma cell membrane glycoprotein PC-1 |
246804 |
2.4.1.212 | hyaluronan synthase |
glioma cell |
cell line |
395258 |
2.4.1.47 | N-acylsphingosine galactosyltransferase |
glioma cell |
human fetal glioma cell line |
489221 |
2.4.1.47 | N-acylsphingosine galactosyltransferase |
glioma cell |
N-370 FG cells |
489221, 489224 |
3.4.24.82 | ADAMTS-4 endopeptidase |
glioma cell |
- |
638956 |
2.7.1.1 | hexokinase |
glioma cell |
hexokinase I, predominant in normal brain |
640259 |
2.7.1.1 | hexokinase |
glioma cell |
hexokinase II, increased in brain tumors, ethylnitrosourea-induced 36B-10 astrocytic F-344 rat brain tumor cell line |
640259 |
2.7.1.127 | inositol-trisphosphate 3-kinase |
glioma cell |
human glioma cell line HTB-138, InsP3 3-kinase B mRNA |
640751 |
2.7.8.11 | CDP-diacylglycerol-inositol 3-phosphatidyltransferase |
glioma cell |
- |
645316 |
3.1.6.13 | iduronate-2-sulfatase |
glioma cell |
- |
650371 |
3.1.4.12 | sphingomyelin phosphodiesterase |
glioma cell |
C6-glioma cells |
652974 |
1.14.15.18 | calcidiol 1-monooxygenase |
glioma cell |
- |
659811 |
2.7.11.11 | cAMP-dependent protein kinase |
glioma cell |
- |
662380 |
3.2.1.143 | poly(ADP-ribose) glycohydrolase |
glioma cell |
primary culture, highest ratio of nuclear to cytoplasmic enzyme activity |
664476 |
3.4.22.61 | caspase-8 |
glioma cell |
- |
664508 |
3.4.22.62 | caspase-9 |
glioma cell |
- |
665736 |
3.1.4.11 | phosphoinositide phospholipase C |
glioma cell |
C6Bu-1 rat glioma cell, isoenzyme PI-PLC-beta1 |
668867 |
3.4.21.26 | prolyl oligopeptidase |
glioma cell |
- |
669933, 683344 |
2.1.1.63 | methylated-DNA-[protein]-cysteine S-methyltransferase |
glioma cell |
- |
673219, 701644, 705897 |
2.7.11.13 | protein kinase C |
glioma cell |
- |
676323 |
4.1.1.17 | ornithine decarboxylase |
glioma cell |
- |
680217, 682982, 697101, 697861 |
5.3.99.3 | prostaglandin-E synthase |
glioma cell |
- |
681868 |
2.7.12.2 | mitogen-activated protein kinase kinase |
glioma cell |
MKK3 i s upregulated and activated in invasive glioma cells in vitro, overexpression and phosphorylation of MKK3 are linked to glioma invasion, MKK3 is overexpressed in invasive glioma cells in situ and correlates with active p38 |
681871 |
3.4.24.24 | gelatinase A |
glioma cell |
high expression level of MMP-2 increasing during growth |
683427 |
3.4.24.35 | gelatinase B |
glioma cell |
high expression level of MMP-9 increasing during growth |
683427 |
3.4.24.23 | matrilysin |
glioma cell |
highly variable MMP-7 expression in the glioma population |
683864 |
2.4.1.38 | beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase |
glioma cell |
- |
685932, 718736 |
1.13.11.34 | arachidonate 5-lipoxygenase |
glioma cell |
high enzyme expression level |
686278 |
1.14.16.4 | tryptophan 5-monooxygenase |
glioma cell |
- |
687604 |
1.13.11.34 | arachidonate 5-lipoxygenase |
glioma cell |
- |
688512 |
2.1.1.63 | methylated-DNA-[protein]-cysteine S-methyltransferase |
glioma cell |
biopsies |
688740 |
1.13.11.31 | arachidonate 12-lipoxygenase |
glioma cell |
- |
688759 |
1.4.3.4 | monoamine oxidase |
glioma cell |
activity selectively increases in MAO-B activity in human gliomas when compared with meningiomas or non-tumoural tissue |
689175 |
2.4.1.109 | dolichyl-phosphate-mannose-protein mannosyltransferase |
glioma cell |
of brain with subarachnoid spread. Distinct POMT1 alterations may contribute to a functional impairment of protein-omannosyltransferase activity. In individual tumor specimens selective alterations of the POMT1 gene may be compatible with clonal evolution of distinct sublocations |
689201 |
1.14.14.18 | heme oxygenase (biliverdin-producing) |
glioma cell |
- |
690140 |
3.1.3.16 | protein-serine/threonine phosphatase |
glioma cell |
- |
692085, 750280 |
3.2.1.166 | heparanase |
glioma cell |
- |
693320, 759360 |
3.1.3.5 | 5'-nucleotidase |
glioma cell |
- |
694138 |
4.6.1.1 | adenylate cyclase |
glioma cell |
- |
694258 |
3.4.22.61 | caspase-8 |
glioma cell |
stem-cell-like and non-stem-cell-like glioma cell |
695401 |
3.4.22.61 | caspase-8 |
glioma cell |
stem-cell-like glioma cell, low enzyme expression levels due to hypermethylation of the CASP8 promoter, also expressed in non-stem-like glioma cell |
695401 |
3.4.22.60 | caspase-7 |
glioma cell |
- |
700938 |
3.4.14.5 | dipeptidyl-peptidase IV |
glioma cell |
- |
703784 |
5.3.99.5 | thromboxane-A synthase |
glioma cell |
- |
705275 |
5.1.1.18 | serine racemase |
glioma cell |
- |
705283 |
3.4.22.1 | cathepsin B |
glioma cell |
astrocytic |
707558 |
3.4.21.B28 | fibroblast activation protein alpha subunit |
glioma cell |
- |
707629 |
3.1.4.4 | phospholipase D |
glioma cell |
- |
708012 |
3.4.24.17 | stromelysin 1 |
glioma cell |
- |
708089 |
3.4.21.75 | Furin |
glioma cell |
- |
708753 |
2.7.1.137 | phosphatidylinositol 3-kinase |
glioma cell |
- |
709276 |
4.4.1.5 | lactoylglutathione lyase |
glioma cell |
- |
709654 |
2.7.1.153 | phosphatidylinositol-4,5-bisphosphate 3-kinase |
glioma cell |
- |
709907 |
3.4.21.73 | u-Plasminogen activator |
glioma cell |
- |
710121 |
3.4.19.12 | ubiquitinyl hydrolase 1 |
glioma cell |
- |
710451 |
1.1.1.42 | isocitrate dehydrogenase (NADP+) |
glioma cell |
progressive gliomas |
711107 |
3.4.24.B4 | matrix metalloproteinase-13 |
glioma cell |
- |
711163 |
1.1.1.41 | isocitrate dehydrogenase (NAD+) |
glioma cell |
- |
712180 |
1.1.1.42 | isocitrate dehydrogenase (NADP+) |
glioma cell |
- |
712180, 712574, 712614, 713113, 739984 |
3.4.22.15 | cathepsin L |
glioma cell |
- |
712921 |
1.1.1.42 | isocitrate dehydrogenase (NADP+) |
glioma cell |
of grade II-III gliomas |
713100 |
3.4.24.B7 | matrix metalloproteinase-26 |
glioma cell |
- |
713160, 754946 |
1.1.1.42 | isocitrate dehydrogenase (NADP+) |
glioma cell |
IDH1, diffuse gliomas graded II-IV |
713508 |
3.4.21.109 | matriptase |
glioma cell |
- |
717799 |
2.7.10.2 | non-specific protein-tyrosine kinase |
glioma cell |
- |
721489 |
1.14.14.14 | aromatase |
glioma cell |
- |
726047 |
2.3.1.B41 | protein-long-chain fatty-acyl-lysine deacylase (NAD+) |
glioma cell |
SIRT6 is down-regulated in human glioma tissues |
729145 |
4.3.2.9 | gamma-glutamylcyclotransferase |
glioma cell |
- |
735619 |
2.4.2.12 | nicotinamide phosphoribosyltransferase |
glioma cell |
- |
735872 |
2.4.1.144 | beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase |
glioma cell |
- |
736507 |
2.1.2.1 | glycine hydroxymethyltransferase |
glioma cell |
expression of SHMT2 in ischemic tumor zones |
736882 |
2.1.2.2 | phosphoribosylglycinamide formyltransferase 1 |
glioma cell |
the enzyme is frequently overexpressed in glioma, enzyme immunohistochemic analysis in 70 cases of human gliomas and normal brain tissues, overview |
736945 |
2.5.1.26 | alkylglycerone-phosphate synthase |
glioma cell |
- |
737578, 739210 |
2.7.8.27 | sphingomyelin synthase |
glioma cell |
- |
737747 |
2.7.1.105 | 6-phosphofructo-2-kinase |
glioma cell |
- |
739621, 761915 |
1.2.1.3 | aldehyde dehydrogenase (NAD+) |
glioma cell |
- |
741427 |
1.14.19.17 | sphingolipid 4-desaturase |
glioma cell |
- |
744686 |
6.3.5.4 | asparagine synthase (glutamine-hydrolysing) |
glioma cell |
- |
745756 |
6.3.1.2 | glutamine synthetase |
glioma cell |
- |
671608, 745832 |
5.4.2.11 | phosphoglycerate mutase (2,3-diphosphoglycerate-dependent) |
glioma cell |
- |
748795 |
3.1.1.89 | protein phosphatase methylesterase-1 |
glioma cell |
in human glioma cell, high PME-1 expression correlates with tumor progression and kinase inhibitor resistance |
749865 |
3.2.1.45 | glucosylceramidase |
glioma cell |
- |
751699 |
3.1.3.77 | acireductone synthase |
glioma cell |
- |
751767 |
3.1.3.7 | 3'(2'),5'-bisphosphate nucleotidase |
glioma cell |
in glioma tissues, phosphocholine(36:1) is not detected and 3'-phosphoadenylate (pAp) content is significantly increased. The gene expression of the 3'-nucleotidase 3'(2'),5'-bisphosphate nucleotidase 1 (BPNT-1) is dramatically downregulated, quantitative real-time polymerase chain reaction (qRT-PCR) expression analysis. Gene expression of enzymes associated with pAp metabolism |
752237 |
3.3.2.6 | leukotriene-A4 hydrolase |
glioma cell |
- |
752495 |
3.4.22.B70 | SENP1 peptidase |
glioma cell |
- |
753729 |
3.4.21.B28 | fibroblast activation protein alpha subunit |
glioma cell |
increased enzyme expression in a subgroup of high-grade gliomas. The enzyme is expressed by several constituents of the glioblastoma microenvironment, including stromal non-malignant mesenchymal cells recruited to and/or activated in response to glioma growth |
755628 |
1.14.11.66 | [histone H3]-trimethyl-L-lysine9 demethylase |
glioma cell |
- |
756531 |
2.3.1.48 | histone acetyltransferase |
glioma cell |
- |
756850 |
2.3.1.57 | diamine N-acetyltransferase |
glioma cell |
- |
757876 |
2.3.1.299 | sphingoid base N-stearoyltransferase |
glioma cell |
- |
757888 |
2.6.1.42 | branched-chain-amino-acid transaminase |
glioma cell |
- |
758657 |
2.7.1.3 | ketohexokinase |
glioma cell |
expressed at significantly higher level in glioma tissues than in non-tumor brain |
758732 |
2.4.2.3 | uridine phosphorylase |
glioma cell |
UPP1 is significantly upregulated in glioma, especially in glioblastoma |
758991 |
2.4.1.101 | alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase |
glioma cell |
cell proliferation and migration analysis, overview |
759196 |
2.4.1.224 | glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase |
glioma cell |
- |
759360 |
2.4.1.225 | N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase |
glioma cell |
- |
759360 |
2.8.2.23 | [heparan sulfate]-glucosamine 3-sulfotransferase 1 |
glioma cell |
- |
759360 |