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Information on EC 2.7.1.153 - phosphatidylinositol-4,5-bisphosphate 3-kinase
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2.7.1.153 phosphatidylinositol-4,5-bisphosphate 3-kinaseIUBMB Comments
This enzyme also catalyses the phosphorylation of PtdIns4P to PtdIns(3,4)P2, and of PtdIns to PtdIns3P. Four mammalian isoforms are known to exist.
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Word Map
- 2.7.1.153
- wortmannin
- pten
- mapks
- mtor
- rapamycin
- endothelial
- erk
- colorectal
-
signal-regulated
- subtypes
-
insulin-like
- pkc
- tumour
- adenocarcinoma
- phospholipase
- akt1
-
insulin-stimulated
- irs-1
- erbb2
-
mitogen
- adipocytes
- integrins
-
tensin
-
insulin-induced
- 3-kinases
-
dominant-negative
-
platelet-derived
-
hotspot
-
pi3k-akt
-
progression-free
- substrate-1
- igf-i
- sh2
-
ctnnb1
-
tyrosine-phosphorylated
-
phosphatidylinositol-3
-
pleckstrin
-
cdkn2a
- rac1
-
pi3k-dependent
-
her2-negative
- cetuximab
-
phosphatidylinositol-3-kinase
-
everolimus
-
anti-egfr
-
pdgfra
- trastuzumab
-
her2-positive
-
phospho-akt
-
endometrioid
- medicine
- pharmacology
- analysis
The enzyme appears in viruses and cellular organisms
Reaction Schemes
Synonyms
pik3ca, phosphoinositide 3-kinase, pi 3-kinase, pi3-kinase, pi3-k, pi-3k, pik3r1, phosphatidylinositol 3'-kinase, p110alpha, pi 3-k, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
class I phosphoinositide 3-kinase
class I PI3K
class IA phosphatidylinositol-4,5-bisphosphate 3-kinase
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CXCR2/phosphatidylinositol 3-kinase gamma
kinase (phosphorylating), phosphatidylinositol 4,5-diphosphate 3-
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p101-PI3K
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-
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p110alpha
p110beta
p110delta
P120-PI3K
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phosphatidyl-inositol-3-kinase
phosphatidylinositol (4,5)-bisphosphate 3-hydroxykinase
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phosphatidylinositol 3'-kinase
phosphatidylinositol 3-hydroxyl kinase
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phosphatidylinositol 3-kinase gamma
phosphatidylinositol-4,5-bisphosphate 3-kinase
phosphoinositide 3-kinase
PI 3-kinase
PI3K
PI3Kalpha
PI3Kbeta
PI3Kdelta
PI3Kgamma
PtdIns(4,5)P2 3-OH kinase
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PtdIns-3-kinase p101
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PtdIns-3-kinase p110
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PtdInsP 3-OH-kinase
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type I phosphoinositide 3-kinase
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additional information
class I phosphoinositide 3-kinase
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class I PI3K
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p110delta
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PI3K
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PI3K
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PI3Kbeta
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PI3Kgamma
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additional information
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class I PI3Ks can be further subtyped depending on their associated catalytic subunit into class IA p110alpha, p110beta and p110delta and class IB p110gamma
additional information
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class I PI3Ks can be further subtyped depending on their associated catalytic subunit into class IA p110alpha, p110beta and p110delta and class IB p110gamma
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phospho-group transfer
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-
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SYSTEMATIC NAME
IUBMB Comments
ATP:1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 3-phosphotransferase
This enzyme also catalyses the phosphorylation of PtdIns4P to PtdIns(3,4)P2, and of PtdIns to PtdIns3P. Four mammalian isoforms are known to exist.
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CAS REGISTRY NUMBER
COMMENTARY
103843-30-7
-
115926-52-8
cf. EC 2.7.1.137
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-triphosphate
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
ATP + phosphatidylinositol-4,5-bisphosphate
ADP + phosphatidylinositol-3,4,5-trisphosphate
ATP + 1-phosphatidyl-1D-myo-inositol
ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
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-
-
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?
ATP + 1-phosphatidyl-1D-myo-inositol
ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
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catalyzed by class I and III, and probably by class II enzymes, overview. PI3K is part of the plasma membrane E-cadherin signaling complex
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-
?
ATP + 1-phosphatidyl-1D-myo-inositol
ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
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-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-triphosphate
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-
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?
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-triphosphate
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catalyzed by class I enzyme, overview. PI3K is part of the plasma membrane E-cadherin signaling complex
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?
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-triphosphate
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-
phosphatidylinositol-3,4,5-triphosphate is a major product of active PI3K, and recruits Akt/PKB to the plasma membrane and the phosphorylation of Akt occurs
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?
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
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-
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?
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
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-
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?
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
-
catalyzed by class I enzyme, overview. PI3K is part of the plasma membrane E-cadherin signaling complex
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?
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
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?
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
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?
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
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-
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?
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
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-
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?
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
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-
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-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
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-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
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?
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
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?
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
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?
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
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?
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
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?
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
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?
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
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?
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
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?
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
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?
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
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?
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
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?
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
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?
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
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?
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
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?
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
p110delta controls a critical checkpoint in peripheral T cell differentiation and clonal expansion
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?
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
PI3Kp110delta is the main source of production of 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate following antigen recognition by B cells, T cells and mast cells
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?
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
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?
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
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?
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
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?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
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?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
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catalyzed by class I enzyme, overview. PI3K is part of the plasma membrane E-cadherin signaling complex
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?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
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?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
-
catalyzed by class I enzyme, overview. PI3K is part of the plasma membrane E-cadherin signaling complex
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?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
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?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
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?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
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PIP3 acts as a positive regulator of the Src signaling pathway in Xenopus fertilization
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?
ATP + phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
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?
ATP + phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
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?
ATP + phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
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?
ATP + phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
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?
ATP + phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
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?
ATP + phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
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?
ATP + phosphatidylinositol 4-phosphate
ADP + phosphatidylinositol 4,5-diphosphate
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?
ATP + phosphatidylinositol 4-phosphate
ADP + phosphatidylinositol 4,5-diphosphate
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?
ATP + phosphatidylinositol 4-phosphate
ADP + phosphatidylinositol 4,5-diphosphate
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?
ATP + phosphatidylinositol 4-phosphate
ADP + phosphatidylinositol 4,5-diphosphate
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?
ATP + phosphatidylinositol 4-phosphate
ADP + phosphatidylinositol 4,5-diphosphate
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?
ATP + phosphatidylinositol 4-phosphate
ADP + phosphatidylinositol 4,5-diphosphate
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?
ATP + phosphatidylinositol 4-phosphate
ADP + phosphatidylinositol 4,5-diphosphate
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?
ATP + phosphatidylinositol-4,5-bisphosphate
ADP + phosphatidylinositol-3,4,5-trisphosphate
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?
ATP + phosphatidylinositol-4,5-bisphosphate
ADP + phosphatidylinositol-3,4,5-trisphosphate
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i.e. PIP3, PIP3 recruits protein dependent kinase 1, PDK1, and AKT, also known as protein kinase B, PKB, to the plasma membrane
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?
ATP + phosphatidylinositol-4,5-bisphosphate
ADP + phosphatidylinositol-3,4,5-trisphosphate
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class I PI3Ks
the product allows for the recruitment to the plasma membrane of proteins containing a pleckstrin homology domain
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?
ATP + phosphatidylinositol-4,5-bisphosphate
ADP + phosphatidylinositol-3,4,5-trisphosphate
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?
ATP + phosphatidylinositol-4,5-bisphosphate
ADP + phosphatidylinositol-3,4,5-trisphosphate
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?
ATP + phosphatidylinositol-4,5-bisphosphate
ADP + phosphatidylinositol-3,4,5-trisphosphate
Neopyropia yezoensis TU-1
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?
additional information
?
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phosphoinositide 3-kinase and DNA synthesis
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?
additional information
?
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enzyme is involved in the synthesis of 3-phosphoinositides. Class I phosphoinositide 3-kinases are further subdivided into class IA and IB enzymes, which signal downstream of tyrosine kinase and heterotrimeric G protein-coupled receptors, respectively. All class I phosphoinositide 3-kinase members also bind to Ras, but the role of this interaction in physiological phosphoinositide 3-kinase signalling is not entirely clear
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?
additional information
?
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phosphoinositide 3-kinase and apoptosis
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?
additional information
?
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the enzyme is activated and associated to E-cadherin complexes, the assembly is mediated by docking proteins, e.g. beta-catenin, gamma-catenin, and Dlg, and involves c-SRC. Cell-cell adhesion induces c-SRC recruitment and E-cadherin complex assembly as well as activity of PI3K, regulatory and molecular mechanism, overview. PI3K, stimulated by E-cadherin adhesion, activates PKB/Akt
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?
additional information
?
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phosphoinositide 3-kinase and DNA synthesis
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?
additional information
?
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enzyme is involved in the synthesis of 3-phosphoinositides. Class I phosphoinositide 3-kinases are further subdivided into class IA and IB enzymes, which signal downstream of tyrosine kinase and heterotrimeric G protein-coupled receptors, respectively. All class I phosphoinositide 3-kinase members also bind to Ras, but the role of this interaction in physiological phosphoinositide 3-kinase signalling is not entirely clear
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?
additional information
?
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phosphoinositide 3-kinase and apoptosis
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?
additional information
?
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phosphoinositide 3-kinase and DNA synthesis
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?
additional information
?
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enzyme is involved in the synthesis of 3-phosphoinositides. Class I phosphoinositide 3-kinases are further subdivided into class IA and IB enzymes, which signal downstream of tyrosine kinase and heterotrimeric G protein-coupled receptors, respectively. All class I phosphoinositide 3-kinase members also bind to Ras, but the role of this interaction in physiological phosphoinositide 3-kinase signalling is not entirely clear
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?
additional information
?
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phosphoinositide 3-kinase and apoptosis
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?
additional information
?
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enzyme is activated by binding of osteopontin to integrin alphavbeta3
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?
additional information
?
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p110delta does not phosphorylate the p85 adaptor but instead harbors an intrinsic autophosphorylation capacity
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?
additional information
?
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involvement of the enzyme in CD18-mediated adhesion of human neutrophils to fibrinogen
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?
additional information
?
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subunit p101 is responsible for phosphatidylinositol-4,5-bisphosphate substrate selectivity of enzyme gamma isoform by sensitizing p110 gamma toward G-protein beta,gamma-subunits in the presence of phosphatidylinositol-4,5-bisphosphate
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?
additional information
?
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PI3K generates phosphatidylinositol 3,4,5 trisphosphate
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?
additional information
?
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the enzyme is activated and associated to E-cadherin complexes, the assembly is mediated by docking proteins, e.g. beta-catenin, gamma-catenin, and Dlg, and involves c-SRC. Cell-cell adhesion induces c-SRC recruitment and E-cadherin complex assembly as well as activity of PI3K, regulatory and molecular mechanism, overview. PI3K, stimulated by E-cadherin adhesion, activates PKB/Akt
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?
additional information
?
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the p85alpha subunit of phosphatidylinositol 3-kinase has GTPase-activating protein activity toward Rab5 and Rab4, small monomeric GTPases important in the regulation of RTK endocytosis, trafficking, and degradation pathways
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?
additional information
?
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the enzyme also catalyzes the reactions of EC 2.7.1.68, 1-phosphatidylinositol-4-phosphate 5-kinase, and EC 2.7.1.67, 1-phosphatidylinositol 4-kinase
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?
additional information
?
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the single class 1B catalytic isoform p110gamma binds to either p101 or p84/p87 adaptors, which function to potentiate activation by betagamma-subunits of heterotrimeric GTP-binding proteins which facilitate intracellular signalling from G-protein coupled receptors
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?
additional information
?
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phosphoinositide 3-kinase (PI3K) is a dual specificity kinase that is able to phosphorylate both lipid and protein substrates. In addition to their lipid kinase activity, all members of the class 1 PI3K family also possess intrinsic protein kinase activity
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?
additional information
?
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phosphoinositide 3-kinase (PI3K) is a dual specificity kinase that is able to phosphorylate both lipid and protein substrates. In addition to their lipid kinase activity, all members of the class 1 PI3K family also possess intrinsic protein kinase activity
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?
additional information
?
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the enzyme is also active as a serine-dependent protein kinase with Src as substrate and specifically phosphorylating residue Ser70 of Src
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?
additional information
?
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the enzyme is also active as a serine-dependent protein kinase with Src as substrate and specifically phosphorylating residue Ser70 of Src. No activity with S70A Src mutant
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?
additional information
?
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enzyme is involved in the synthesis of 3-phosphoinositides. Class I phosphoinositide 3-kinases are further subdivided into class IA and IB enzymes, which signal downstream of tyrosine kinase and heterotrimeric G protein-coupled receptors, respectively. All class I phosphoinositide 3-kinase members also bind to Ras, but the role of this interaction in physiological phosphoinositide 3-kinase signalling is not entirely clear
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?
additional information
?
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the adaptor subunits of the class IA enzymes bind phosphorylated Tyr residues, thereby linking the phosphoinositide 3-kinases catalytic subunit to tyr kinase signalling pathways
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?
additional information
?
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mechanism of signal down-regulation of insulin receptor substrate mediated by monomeric p85 enzyme regulatory subunit
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additional information
?
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p110delta is an important signaling component for efficient axonal elongation in the developing and regenerating nervous system
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additional information
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p110delta isoform of PI 3-kinase negatively controls RhoA and PTEN
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?
additional information
?
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PI3K p110delta contributes to cellular and humoral immunity. PI3K p110delta regulates the diffentiation of peripheral helper T-cells towards the Th1 and Th2 lineages. PI3K p110delta is critical to regulatory T-cell development and function
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additional information
?
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PI3K p110delta play a role in the regulation of RAG gene expression and thereby LC allelic/isotype exclusion
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additional information
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PI3Kgamma plays an important role in neutrophil emigration but not rolling and limited adhesion in postcapillary venules in vivo. The leukocyte but not the endothelial PI3Kgamma is critically involved in the early neutrophil emigration into the inflamed tissues. The delayed neutrophil emigration in response to neutrophil chemokines is independent of the function of PI3Lgamma but is PI3Kdelta dependent
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additional information
?
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PI3Kgamma plays an important role in neutrophil emigration but not rolling and limited adhesion in postcapillary venules in vivo. The leukocyte but not the endothelial PI3Kgamma is critically involved in the early neutrophil emigration into the inflamed tissues. The delayed neutrophil emigration in response to neutrophil chemokines is independent of the function of PI3Lgamma but is PI3Kdelta dependent
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additional information
?
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role of the phosphoinositide 3-kinase p110delta in generation of type 2 cytokine responses and allergic airway inflammation
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additional information
?
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the delayed neutrophil emigration in response to neutrophil chemokines is independent of the function of PI3Lgamma but is PI3Kdelta dependent
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additional information
?
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the delayed neutrophil emigration in response to neutrophil chemokines is independent of the function of PI3Lgamma but is PI3Kdelta dependent
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?
additional information
?
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function of class IA phosphatidylinositol 3-kinases in the pre-T-cell receptor-controlled developmental transition of CD4-/CD8- double-negative to CD4+/CD8+ double-positive thymocytes
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?
additional information
?
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molecular model for the regulation of PI3K signaling by NCoR, a receptor corepressor and regulator of thyroid receptor-activated PI3K signaling
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?
additional information
?
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the single class 1B catalytic isoform p110gamma binds to either p101 or p84/p87 adaptors, which function to potentiate activation by betagamma-subunits of heterotrimeric GTP-binding proteins which facilitate intracellular signalling from G-protein coupled receptors
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?
additional information
?
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a p110alpha/beta-subunit binds to a p85 regulatory subunit, and this heterodimer is recruited to the membrane through the association with phosphotyrosyl proteins, leading to production of phosphatidylinositol 3,4,5-triphosphate, PIP3, followed by activation of downstream signal pathway(s)
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